Inactivation of Caspase‐1 in Rodent Brain: A Novel Anticonvulsive Strategy

Purpose: Cytokines and related inflammatory mediators are rapidly synthesized in the brain during seizures. We previously found that intracerebral administration of interleukin‐1 (IL‐1)‐β has proconvulsant effects, whereas its endogenous receptor antagonist (IL‐1Ra) mediates potent anticonvulsant ac...

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Veröffentlicht in:	Epilepsia (Copenhagen) 2006-07, Vol.47 (7), p.1160-1168
Hauptverfasser:	Ravizza, Teresa, Lucas, Sian‐Marie, Balosso, Silvia, Bernardino, Liliana, Ku, George, Noé, Francesco, Malva, Joao, Randle, John C. R., Allan, Stuart, Vezzani, Annamaria
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - pharmacology Azepines - pharmacology Biological and medical sciences Brain - drug effects Brain - enzymology Brain - metabolism Caspase 1 - genetics Caspase Inhibitors Cytokines Disease Models, Animal Diseases of the nervous system Epilepsy Glia Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus Hippocampus - drug effects Hippocampus - metabolism Inflammation Interleukin-1 - antagonists & inhibitors Interleukin-1 - metabolism Interleukin‐1β Isoquinolines - pharmacology Kainic Acid Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Nervous system (semeiology, syndromes) Neurology Prodrugs - pharmacology Protease Inhibitors - pharmacology Pyridazines - pharmacology Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Rats Seizures - chemically induced Seizures - metabolism Seizures - prevention & control Tissue Culture Techniques Vascular diseases and vascular malformations of the nervous system
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