Activities of human exonuclease 1 that promote cleavage of transcribed immunoglobulin switch regions

Eukaryotic exonuclease 1 functions in replication, recombination, mismatch repair, telomere maintenance, immunoglobulin (Ig) gene class switch recombination, and somatic hypermutation. The enzyme has 5'-3' exonuclease, flap endonuclease, and weak RNaseH activity in vitro, but it has been d...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-10, Vol.105 (43), p.16508-16512
Hauptverfasser:	Vallur, Aarthy C, Maizels, Nancy
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Animals B lymphocytes Biological Sciences Cytidine Deaminase - metabolism Deoxyribonucleic acid DNA DNA mismatch repair DNA Repair Enzymes - metabolism DNA Repair Enzymes - physiology Enzyme substrates Enzymes Eukaryotes Exodeoxyribonucleases - metabolism Exodeoxyribonucleases - physiology Humans Hybridity Hydrolysis Immunoglobulin Class Switching - genetics Immunoglobulin Switch Region - genetics Immunoglobulins Immunology Mice Mice, Knockout Plasmids Promoter regions RNA Transcription, Genetic
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