Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain
Neuropathic pain is a chronic pain that results from lesion or dysfunction of the nervous system. Depression and cognitive decline are often coupled to chronic pain, suggesting the involvement of cortical areas associated with higher cognitive functions. We investigated layer 2/3 pyramidal neurons i...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2009-02, Vol.106 (7), p.2423-2428 |
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| creator | Metz, Alexia E Yau, Hau-Jie Centeno, Maria Virginia Apkarian, A. Vania Martina, Marco |
| description | Neuropathic pain is a chronic pain that results from lesion or dysfunction of the nervous system. Depression and cognitive decline are often coupled to chronic pain, suggesting the involvement of cortical areas associated with higher cognitive functions. We investigated layer 2/3 pyramidal neurons in acute slices of the contralateral medial prefrontal cortex (mPFC) in the rat spared nerve injury (SNI) model of neuropathic pain and found morphological and functional differences between the mPFC of SNI and sham-operated animals. Basal, but not apical, dendrites of neurons from SNI rats are longer and have more branches than their counterparts in sham-operated animals; spine density is also selectively increased in basal dendrites of neurons from SNI rats; the morphological changes are accompanied by increased contribution to synaptic currents of the NMDA component. Interestingly, the NMDA/AMPA ratio of the synaptic current elicited in mPFC neurons by afferent fiber stimulation shows linear correlation with the rats' tactile threshold in the injured (but not in the contralateral) paw. Our results not only provide evidence that neuropathic pain leads to rearrangement of the mPFC, which may help defining the cellular basis for cognitive impairments associated with chronic pain, but also show pain-associated morphological changes in the cortex at single neuron level. |
| doi_str_mv | 10.1073/pnas.0809897106 |
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Vania ; Martina, Marco</creator><creatorcontrib>Metz, Alexia E ; Yau, Hau-Jie ; Centeno, Maria Virginia ; Apkarian, A. Vania ; Martina, Marco</creatorcontrib><description>Neuropathic pain is a chronic pain that results from lesion or dysfunction of the nervous system. Depression and cognitive decline are often coupled to chronic pain, suggesting the involvement of cortical areas associated with higher cognitive functions. We investigated layer 2/3 pyramidal neurons in acute slices of the contralateral medial prefrontal cortex (mPFC) in the rat spared nerve injury (SNI) model of neuropathic pain and found morphological and functional differences between the mPFC of SNI and sham-operated animals. Basal, but not apical, dendrites of neurons from SNI rats are longer and have more branches than their counterparts in sham-operated animals; spine density is also selectively increased in basal dendrites of neurons from SNI rats; the morphological changes are accompanied by increased contribution to synaptic currents of the NMDA component. Interestingly, the NMDA/AMPA ratio of the synaptic current elicited in mPFC neurons by afferent fiber stimulation shows linear correlation with the rats' tactile threshold in the injured (but not in the contralateral) paw. Our results not only provide evidence that neuropathic pain leads to rearrangement of the mPFC, which may help defining the cellular basis for cognitive impairments associated with chronic pain, but also show pain-associated morphological changes in the cortex at single neuron level.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0809897106</identifier><identifier>PMID: 19171885</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Animal morphology ; Animals ; Behavior, Animal - physiology ; Behavioral neuroscience ; Biological Sciences ; Brain ; Brain - metabolism ; Cerebral Cortex - physiopathology ; Chronic pain ; Dendrites ; Dendrites - metabolism ; Electrophysiology ; Emotional distress ; Nervous system ; Neuralgia - metabolism ; Neurons ; Neurons - metabolism ; Neurons - pathology ; Pain ; Pain Management ; Pain Threshold - physiology ; Patch-Clamp Techniques ; Prefrontal cortex ; Prefrontal Cortex - metabolism ; Prefrontal Cortex - physiology ; Pyramidal cells ; Rats ; Rodents</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2009-02, Vol.106 (7), p.2423-2428</ispartof><rights>Copyright National Academy of Sciences Feb 17, 2009</rights><rights>2009 by The National Academy of Sciences of the USA</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c616t-19a09a931373d6547d5c8e96f05ee781e29c26ff01a5905d38e792eb43db28e3</citedby><cites>FETCH-LOGICAL-c616t-19a09a931373d6547d5c8e96f05ee781e29c26ff01a5905d38e792eb43db28e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/106/7.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40272687$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40272687$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19171885$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Metz, Alexia E</creatorcontrib><creatorcontrib>Yau, Hau-Jie</creatorcontrib><creatorcontrib>Centeno, Maria Virginia</creatorcontrib><creatorcontrib>Apkarian, A. Vania</creatorcontrib><creatorcontrib>Martina, Marco</creatorcontrib><title>Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Neuropathic pain is a chronic pain that results from lesion or dysfunction of the nervous system. Depression and cognitive decline are often coupled to chronic pain, suggesting the involvement of cortical areas associated with higher cognitive functions. We investigated layer 2/3 pyramidal neurons in acute slices of the contralateral medial prefrontal cortex (mPFC) in the rat spared nerve injury (SNI) model of neuropathic pain and found morphological and functional differences between the mPFC of SNI and sham-operated animals. Basal, but not apical, dendrites of neurons from SNI rats are longer and have more branches than their counterparts in sham-operated animals; spine density is also selectively increased in basal dendrites of neurons from SNI rats; the morphological changes are accompanied by increased contribution to synaptic currents of the NMDA component. Interestingly, the NMDA/AMPA ratio of the synaptic current elicited in mPFC neurons by afferent fiber stimulation shows linear correlation with the rats' tactile threshold in the injured (but not in the contralateral) paw. Our results not only provide evidence that neuropathic pain leads to rearrangement of the mPFC, which may help defining the cellular basis for cognitive impairments associated with chronic pain, but also show pain-associated morphological changes in the cortex at single neuron level.</description><subject>Animal morphology</subject><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Behavioral neuroscience</subject><subject>Biological Sciences</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Chronic pain</subject><subject>Dendrites</subject><subject>Dendrites - metabolism</subject><subject>Electrophysiology</subject><subject>Emotional distress</subject><subject>Nervous system</subject><subject>Neuralgia - metabolism</subject><subject>Neurons</subject><subject>Neurons - metabolism</subject><subject>Neurons - pathology</subject><subject>Pain</subject><subject>Pain Management</subject><subject>Pain Threshold - physiology</subject><subject>Patch-Clamp Techniques</subject><subject>Prefrontal cortex</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Prefrontal Cortex - physiology</subject><subject>Pyramidal cells</subject><subject>Rats</subject><subject>Rodents</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkktvEzEUhS0EomlhzQoYsYBV2mt7_NpUQhUvqYgFZW05Hk_iaGIPtgcBv74eJWoKC1j5cT4f3XuPEXqG4RyDoBdjMPkcJCipBAb-AC0wKLzkrYKHaAFAxFK2pD1BpzlvAUAxCY_RCVZYYCnZAunPMY2bOMS1t2ZoTOiafgq2-BjqMbmY1ib432a-aGLfJFOanet8Fcfk-hRDqVsbU3E_Gx-a4KYUR1M23jaj8eEJetSbIbunh_UM3bx_d3P1cXn95cOnq7fXS8sxL0usDCijKKaCdpy1omNWOsV7YM4JiR1RlvC-B2yYAtZR6YQibtXSbkWko2focm87TqtannWhJDPoMfmdSb90NF7_qQS_0ev4QxPOAAtSDV4fDFL8Prlc9M5n64bBBBenrDlXVBAG_wUJEAqcywq--gvcxinVqc4MbgkR7Qxd7CGbYs51oHclY9BzwnpOWB8Tri9e3O_0yB8ivQfML492XAtNWkIr8OafgO6nYahxlko-35PbXGK6Q9v6rQiXouov93pvojbr5LP-9rU2RwEzxRRm9BYq984K</recordid><startdate>20090217</startdate><enddate>20090217</enddate><creator>Metz, Alexia E</creator><creator>Yau, Hau-Jie</creator><creator>Centeno, Maria Virginia</creator><creator>Apkarian, A. 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Vania</au><au>Martina, Marco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2009-02-17</date><risdate>2009</risdate><volume>106</volume><issue>7</issue><spage>2423</spage><epage>2428</epage><pages>2423-2428</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Neuropathic pain is a chronic pain that results from lesion or dysfunction of the nervous system. Depression and cognitive decline are often coupled to chronic pain, suggesting the involvement of cortical areas associated with higher cognitive functions. We investigated layer 2/3 pyramidal neurons in acute slices of the contralateral medial prefrontal cortex (mPFC) in the rat spared nerve injury (SNI) model of neuropathic pain and found morphological and functional differences between the mPFC of SNI and sham-operated animals. Basal, but not apical, dendrites of neurons from SNI rats are longer and have more branches than their counterparts in sham-operated animals; spine density is also selectively increased in basal dendrites of neurons from SNI rats; the morphological changes are accompanied by increased contribution to synaptic currents of the NMDA component. Interestingly, the NMDA/AMPA ratio of the synaptic current elicited in mPFC neurons by afferent fiber stimulation shows linear correlation with the rats' tactile threshold in the injured (but not in the contralateral) paw. Our results not only provide evidence that neuropathic pain leads to rearrangement of the mPFC, which may help defining the cellular basis for cognitive impairments associated with chronic pain, but also show pain-associated morphological changes in the cortex at single neuron level.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>19171885</pmid><doi>10.1073/pnas.0809897106</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animal morphology Animals Behavior, Animal - physiology Behavioral neuroscience Biological Sciences Brain Brain - metabolism Cerebral Cortex - physiopathology Chronic pain Dendrites Dendrites - metabolism Electrophysiology Emotional distress Nervous system Neuralgia - metabolism Neurons Neurons - metabolism Neurons - pathology Pain Pain Management Pain Threshold - physiology Patch-Clamp Techniques Prefrontal cortex Prefrontal Cortex - metabolism Prefrontal Cortex - physiology Pyramidal cells Rats Rodents |
| title | Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain |
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