Rapamycin inhibits trypanosome cell growth by preventing TOR complex 2 formation

Target of rapamycin (TOR) kinases control cell growth through two functionally distinct multiprotein complexes. TOR complex 1 (TORC1) controls temporal cell growth and is sensitive to rapamycin, whereas TOR complex 2 (TORC2) is rapamycin resistant and regulates spatial cell growth. Here, we identifi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-09, Vol.105 (38), p.14579-14584
Hauptverfasser:	Barquilla, Antonio, Crespo, José L, Navarro, Miguel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiprotozoal Agents - pharmacology Biochemistry Biological Sciences Cell cycle Cell growth Cell lines Cell Polarity Cell Proliferation - drug effects Cytokinesis - drug effects Eukaryotes Eukaryotic cells Gene expression regulation Immunoblotting Immunoprecipitation Intracellular Space - metabolism Kinases Multiprotein Complexes - metabolism Parasitic protozoa Protein Biosynthesis Protein synthesis Protein-Serine-Threonine Kinases - metabolism Proteins Protozoan Proteins - metabolism RNA Interference Signal Transduction - drug effects Sirolimus - pharmacology Torcs Transcription Factors - metabolism Trypanosoma brucei Trypanosoma brucei brucei - drug effects Trypanosoma brucei brucei - genetics Trypanosoma brucei brucei - growth & development Trypanosoma brucei brucei - ultrastructure Trypanosome Yeasts
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!