α-Tocopherol-based cationic amphiphiles with a novel pH sensitive hybrid linker for gene delivery

Endosomal escape is one of the barriers for the efficient liposomal gene delivery. To address this and based on earlier encouraging results using tocopherol cationic lipids, we elaborated chemical modifications on tocopherol cationic lipids by introducing a novel hybrid pH sensitive linker "eth...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Organic & biomolecular chemistry 2018-04, Vol.16 (16), p.2932-2946
Hauptverfasser:	Muripiti, Venkanna, Rachamalla, Hari Krishnareddy, Banerjee, Rajkumar, Patri, Srilakshmi. V
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Tocopherol Ammonium Anchoring Animals Biotechnology Cations Cell lines Deoxyribonucleic acid DNA Gene transfer Gene Transfer Techniques HEK293 Cells Humans Lipids Liposomes Liposomes - chemistry Mice NIH 3T3 Cells pH effects Phosphatidylethanolamines Phospholipids Tocopherol Transfection Vitamin E
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!