Elevated expression of keratin 17 in oropharyngeal squamous cell carcinoma is associated with decreased survival
Background Overexpression of keratin 17 (K17) is highly associated with poor prognosis in squamous cell carcinoma (SCC) of the cervix. This study was performed to (1) determine whether K17 may be a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC) and (2) to establish if K17 expr...
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| Veröffentlicht in: | Head & neck 2018-08, Vol.40 (8), p.1788-1798 |
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| container_title | Head & neck |
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| creator | Regenbogen, Elliot Mo, Michelle Romeiser, Jamie Shroyer, A. Laurie W. Escobar‐Hoyos, Luisa F. Burke, Stephanie Shroyer, Kenneth R. |
| description | Background
Overexpression of keratin 17 (K17) is highly associated with poor prognosis in squamous cell carcinoma (SCC) of the cervix. This study was performed to (1) determine whether K17 may be a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC) and (2) to establish if K17 expression is associated with human papillomavirus (HPV) status.
Methods
Immunohistochemical staining was performed for K17 of oral, oropharyngeal, and laryngeal SCCs, and normal oropharyngeal mucosa. The HPV status was determined using polymerase chain reaction (PCR).
Results
Elevated K17 expression was significantly associated with an overall decreased patient survival (P = .02) and, more specifically, in patients with oropharyngeal SCC (P = .01). When controlling for HPV status and tumor location K17 was still a significant predictor of survival (P = .01).
Conclusion
Therefore, K17 is a novel prognostic biomarker of poor survival for patients with HNSCCs, controlling for anatomic site and HPV status. |
| doi_str_mv | 10.1002/hed.25164 |
| format | Article |
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Overexpression of keratin 17 (K17) is highly associated with poor prognosis in squamous cell carcinoma (SCC) of the cervix. This study was performed to (1) determine whether K17 may be a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC) and (2) to establish if K17 expression is associated with human papillomavirus (HPV) status.
Methods
Immunohistochemical staining was performed for K17 of oral, oropharyngeal, and laryngeal SCCs, and normal oropharyngeal mucosa. The HPV status was determined using polymerase chain reaction (PCR).
Results
Elevated K17 expression was significantly associated with an overall decreased patient survival (P = .02) and, more specifically, in patients with oropharyngeal SCC (P = .01). When controlling for HPV status and tumor location K17 was still a significant predictor of survival (P = .01).
Conclusion
Therefore, K17 is a novel prognostic biomarker of poor survival for patients with HNSCCs, controlling for anatomic site and HPV status.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.25164</identifier><identifier>PMID: 29626364</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>biomarker ; Biomarkers ; Cervix ; Head & neck cancer ; head and neck ; head and neck carcinoma ; Human papillomavirus ; immunopathology ; Keratin ; keratin 17 ; Medical prognosis ; Mucosa ; Neck ; Polymerase chain reaction ; Squamous cell carcinoma ; Throat cancer</subject><ispartof>Head & neck, 2018-08, Vol.40 (8), p.1788-1798</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3534-b807a601500e4c3d5bca9a3b93df818bfb1eb129c2dbb1c696376303e390fa63</citedby><cites>FETCH-LOGICAL-c3534-b807a601500e4c3d5bca9a3b93df818bfb1eb129c2dbb1c696376303e390fa63</cites><orcidid>0000-0001-8146-5691</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.25164$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.25164$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29626364$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Regenbogen, Elliot</creatorcontrib><creatorcontrib>Mo, Michelle</creatorcontrib><creatorcontrib>Romeiser, Jamie</creatorcontrib><creatorcontrib>Shroyer, A. Laurie W.</creatorcontrib><creatorcontrib>Escobar‐Hoyos, Luisa F.</creatorcontrib><creatorcontrib>Burke, Stephanie</creatorcontrib><creatorcontrib>Shroyer, Kenneth R.</creatorcontrib><title>Elevated expression of keratin 17 in oropharyngeal squamous cell carcinoma is associated with decreased survival</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Overexpression of keratin 17 (K17) is highly associated with poor prognosis in squamous cell carcinoma (SCC) of the cervix. This study was performed to (1) determine whether K17 may be a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC) and (2) to establish if K17 expression is associated with human papillomavirus (HPV) status.
Methods
Immunohistochemical staining was performed for K17 of oral, oropharyngeal, and laryngeal SCCs, and normal oropharyngeal mucosa. The HPV status was determined using polymerase chain reaction (PCR).
Results
Elevated K17 expression was significantly associated with an overall decreased patient survival (P = .02) and, more specifically, in patients with oropharyngeal SCC (P = .01). When controlling for HPV status and tumor location K17 was still a significant predictor of survival (P = .01).
Conclusion
Therefore, K17 is a novel prognostic biomarker of poor survival for patients with HNSCCs, controlling for anatomic site and HPV status.</description><subject>biomarker</subject><subject>Biomarkers</subject><subject>Cervix</subject><subject>Head & neck cancer</subject><subject>head and neck</subject><subject>head and neck carcinoma</subject><subject>Human papillomavirus</subject><subject>immunopathology</subject><subject>Keratin</subject><subject>keratin 17</subject><subject>Medical prognosis</subject><subject>Mucosa</subject><subject>Neck</subject><subject>Polymerase chain reaction</subject><subject>Squamous cell carcinoma</subject><subject>Throat cancer</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kb1OwzAURi0E4qcw8ALIEgsMgWs7dZIRQaFIlVi6R7ZzQw1JHOym0LfHpWVBYrGvraOjT_cj5JzBDQPgtwusbviYyXSPHDMosgREmu1v5lQkArL0iJyE8AYAQqb8kBzxQnIZ52PSTxpcqSVWFL96jyFY11FX03f0amk7yjIaT-ddv1B-3b2iamj4GFTrhkANNg01yhvbuVZRG6gKwRn74_u0ywWt0HhUIT7D4Fd2pZpTclCrJuDZ7h6R-eNkfj9NZi9Pz_d3s8SIsUgTnUOmJLAxAKZGVGNtVKGELkRV5yzXtWaoGS8Mr7RmRhZSZFKAQFFAraQYkauttvfuY8CwLFsbNnlVhzF6yYHzIhd5nkb08g_65gbfxXCRynOIRsYidb2ljHcheKzL3ts27qRkUG5aKGML5U8Lkb3YGQfdxt9f8nftEbjdAp-2wfX_pnI6edgqvwE-15Gj</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Regenbogen, Elliot</creator><creator>Mo, Michelle</creator><creator>Romeiser, Jamie</creator><creator>Shroyer, A. Laurie W.</creator><creator>Escobar‐Hoyos, Luisa F.</creator><creator>Burke, Stephanie</creator><creator>Shroyer, Kenneth R.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8146-5691</orcidid></search><sort><creationdate>201808</creationdate><title>Elevated expression of keratin 17 in oropharyngeal squamous cell carcinoma is associated with decreased survival</title><author>Regenbogen, Elliot ; Mo, Michelle ; Romeiser, Jamie ; Shroyer, A. Laurie W. ; Escobar‐Hoyos, Luisa F. ; Burke, Stephanie ; Shroyer, Kenneth R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3534-b807a601500e4c3d5bca9a3b93df818bfb1eb129c2dbb1c696376303e390fa63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>biomarker</topic><topic>Biomarkers</topic><topic>Cervix</topic><topic>Head & neck cancer</topic><topic>head and neck</topic><topic>head and neck carcinoma</topic><topic>Human papillomavirus</topic><topic>immunopathology</topic><topic>Keratin</topic><topic>keratin 17</topic><topic>Medical prognosis</topic><topic>Mucosa</topic><topic>Neck</topic><topic>Polymerase chain reaction</topic><topic>Squamous cell carcinoma</topic><topic>Throat cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Regenbogen, Elliot</creatorcontrib><creatorcontrib>Mo, Michelle</creatorcontrib><creatorcontrib>Romeiser, Jamie</creatorcontrib><creatorcontrib>Shroyer, A. Laurie W.</creatorcontrib><creatorcontrib>Escobar‐Hoyos, Luisa F.</creatorcontrib><creatorcontrib>Burke, Stephanie</creatorcontrib><creatorcontrib>Shroyer, Kenneth R.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Regenbogen, Elliot</au><au>Mo, Michelle</au><au>Romeiser, Jamie</au><au>Shroyer, A. Laurie W.</au><au>Escobar‐Hoyos, Luisa F.</au><au>Burke, Stephanie</au><au>Shroyer, Kenneth R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated expression of keratin 17 in oropharyngeal squamous cell carcinoma is associated with decreased survival</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2018-08</date><risdate>2018</risdate><volume>40</volume><issue>8</issue><spage>1788</spage><epage>1798</epage><pages>1788-1798</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Overexpression of keratin 17 (K17) is highly associated with poor prognosis in squamous cell carcinoma (SCC) of the cervix. This study was performed to (1) determine whether K17 may be a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC) and (2) to establish if K17 expression is associated with human papillomavirus (HPV) status.
Methods
Immunohistochemical staining was performed for K17 of oral, oropharyngeal, and laryngeal SCCs, and normal oropharyngeal mucosa. The HPV status was determined using polymerase chain reaction (PCR).
Results
Elevated K17 expression was significantly associated with an overall decreased patient survival (P = .02) and, more specifically, in patients with oropharyngeal SCC (P = .01). When controlling for HPV status and tumor location K17 was still a significant predictor of survival (P = .01).
Conclusion
Therefore, K17 is a novel prognostic biomarker of poor survival for patients with HNSCCs, controlling for anatomic site and HPV status.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29626364</pmid><doi>10.1002/hed.25164</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-8146-5691</orcidid></addata></record> |
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| source | Wiley Online Library Journals |
| subjects | biomarker Biomarkers Cervix Head & neck cancer head and neck head and neck carcinoma Human papillomavirus immunopathology Keratin keratin 17 Medical prognosis Mucosa Neck Polymerase chain reaction Squamous cell carcinoma Throat cancer |
| title | Elevated expression of keratin 17 in oropharyngeal squamous cell carcinoma is associated with decreased survival |
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