What Is the Role of α-Blockers for Medical Expulsive Therapy? Results From a Meta-analysis of 60 Randomized Trials and Over 9500 Patients

What Is the Role of α-Blockers for Medical Expulsive Therapy? Results From a Meta-analysis of 60 Randomized Trials and Over 9500 Patients

Use of α-blockers for medical expulsive therapy (MET) has been the subject of huge debate in urology. Moreover, there have been a number of randomized controlled trials with differing results. We conducted a systematic review and meta-analysis of randomized controlled trials investigating the effica...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Urology (Ridgewood, N.J.) N.J.), 2018-09, Vol.119, p.5-16
Hauptverfasser: Aboumarzouk, Omar M., Jones, Patrick, Amer, Tarik, Kotsiris, Dimitris, Emiliani, Esteban, Somani, Bhaskar, Kallidonis, Panagiotis, Tailly, Thomas, Atis, Gohkan, Greco, Francesco, Hruby, Stephan, Alvarez, Mario, Al-Rumaihi, Khalid, Shamsodini, Ahmad, Al-Ansari, Abdulla, Shokeir, Ahmed
Format: Artikel
Sprache:eng
Schlagworte:
Adrenergic alpha-Antagonists - therapeutic use
Humans
Randomized Controlled Trials as Topic
Treatment Outcome
Ureteral Calculi - drug therapy
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Use of α-blockers for medical expulsive therapy (MET) has been the subject of huge debate in urology. Moreover, there have been a number of randomized controlled trials with differing results. We conducted a systematic review and meta-analysis of randomized controlled trials investigating the efficacy of α-blockers for MET. This review confirms there is a role for α-blockers in MET for ureteric stones specifically in stones >5 mm and distal ureteric stones, which is associated with improved stone expulsion. However, there is a slight increase in risk of nonsignificant side effects.
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2018.03.028