HIGH SHEAR GRANULATION PROCESS: ASSESSING IMPACT OF FORMULATION VARIABLES ON GRANULES AND TABLETS CHARACTERISTICS OF HIGH DRUG LOADING FORMULATION USING DESIGN OF EXPERIMENT METHODOLOGY

High shear wet granulation is a significant component procedure in the pharmaceutical industry. The objective of the study was to investigate the influence of two independent formulation variables; polyvinypyrrolidone (PVP) as a binder (X,) and croscarmellose sodium (CCS) as a disintegrant (X2) on t...

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Veröffentlicht in:	Acta Poloniae pharmaceutica 2017-03, Vol.74 (2), p.551-564
Hauptverfasser:	Fayed, Mohamed H, Abdel-Rahman, Sayed I, Alanazi, Fars K, Ahmed, Mahrous O, Tawfeek, Hesham M, Ali, Bahaa E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - chemistry Analgesics, Non-Narcotic - chemistry Analysis of Variance Carboxymethylcellulose Sodium - chemistry Chemistry, Pharmaceutical Drug Compounding Drug Liberation Excipients - chemistry Kinetics Models, Chemical Particle Size Povidone - chemistry Rheology Solubility Tablets Technology, Pharmaceutical - methods
Online-Zugang:	Volltext
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