Patterns of Treatment Failure in Patients with Sinonasal Mucosal Melanoma
Background Head and neck mucosal melanoma is a locally aggressive tumor with a high recurrence rate. The paranasal sinuses and nasal cavity are the most common primary tumor sites. Objective The purpose of this retrospective study was to identify independent predictors of outcome in sinonasal mucosa...
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| Veröffentlicht in: | Annals of surgical oncology 2018-06, Vol.25 (6), p.1723-1729 |
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| creator | Amit, Moran Tam, Samantha Abdelmeguid, Ahmed S. Kupferman, Michael E. Su, Shirley Y. Raza, Shaan M. DeMonte, Franco Hanna, Ehab Y. |
| description | Background
Head and neck mucosal melanoma is a locally aggressive tumor with a high recurrence rate. The paranasal sinuses and nasal cavity are the most common primary tumor sites.
Objective
The purpose of this retrospective study was to identify independent predictors of outcome in sinonasal mucosal melanoma (SNMM) and characterize the patterns of treatment failure.
Methods
This study included 198 patients with SNMM who had been treated at The University of Texas MD Anderson Cancer Center from 1 January 1991 through 31 December 2016. The survival outcomes included overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), local recurrence-free survival, and distant metastasis-free survival. A stepwise regression analysis was used to assess associations in the multivariate models.
Results
The 5-year OS, DSS, and DFS rates were 38, 58, and 27%, respectively. Independent predictors of poor OS and DSS were the paranasal sinuses as the primary tumor site [hazard ratio (HR) 1.73, 95% confidence interval (CI) 1.11–2.66; and HR 2.12, 95% CI 1.21–3.74, respectively] and the presence of distant metastases at presentation (HR 4.53, 95% CI 2.24–7.83; and HR 3.6, 95% CI 1.12–7.1). Recurrence occurred in 96 patients (48%). The most common cause of treatment failure was distant metastasis in 69 of 198 patients (35%), followed by local [36 (18%)] and regional [22 (11%)] recurrence.
Conclusion
The most common cause of treatment failure in SNMM is distant metastasis. The tumor site and the presence of metastatic disease at presentation were the only independent predictors of survival. These data can be used to inform quality improvement efforts and the counseling of high-risk SNMM patients. |
| doi_str_mv | 10.1245/s10434-018-6465-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2022978627</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2022978627</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-e4be0e834f7804e8c95f31d7cf4fac26e1e91cb5683a76db4b008abb300c19473</originalsourceid><addsrcrecordid>eNp1kE1LAzEQhoMotlZ_gBcJePGymu_NHqVYLVQUrOeQTWd1y37UZBfpvzf9UEHwNGHyzDvDg9A5JdeUCXkTKBFcJITqRAklk_UBGlIZO0JpehjfROkkY0oO0EkIS0Joyok8RgOWKaY40UM0fbZdB74JuC3w3IPtamg6PLFl1XvAZYMjUMZWwJ9l945fyqZtbLAVfuxdu61Q2aat7Sk6KmwV4GxfR-h1cjcfPySzp_vp-HaWOJ6yLgGRAwHNRZFqIkC7TBacLlJXiMI6poBCRl0uleY2VYtc5IRom-ecEEczkfIRutrlrnz70UPoTF0GB1W8Ato-GEYYy1Kt2Aa9_IMu29438botJaSSmkWK7ijn2xA8FGbly9r6taHEbDybnWcTPZuNZ7OOMxf75D6vYfEz8S02AmwHhPjVvIH_Xf1_6hf72YgW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2022456582</pqid></control><display><type>article</type><title>Patterns of Treatment Failure in Patients with Sinonasal Mucosal Melanoma</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Amit, Moran ; Tam, Samantha ; Abdelmeguid, Ahmed S. ; Kupferman, Michael E. ; Su, Shirley Y. ; Raza, Shaan M. ; DeMonte, Franco ; Hanna, Ehab Y.</creator><creatorcontrib>Amit, Moran ; Tam, Samantha ; Abdelmeguid, Ahmed S. ; Kupferman, Michael E. ; Su, Shirley Y. ; Raza, Shaan M. ; DeMonte, Franco ; Hanna, Ehab Y.</creatorcontrib><description>Background
Head and neck mucosal melanoma is a locally aggressive tumor with a high recurrence rate. The paranasal sinuses and nasal cavity are the most common primary tumor sites.
Objective
The purpose of this retrospective study was to identify independent predictors of outcome in sinonasal mucosal melanoma (SNMM) and characterize the patterns of treatment failure.
Methods
This study included 198 patients with SNMM who had been treated at The University of Texas MD Anderson Cancer Center from 1 January 1991 through 31 December 2016. The survival outcomes included overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), local recurrence-free survival, and distant metastasis-free survival. A stepwise regression analysis was used to assess associations in the multivariate models.
Results
The 5-year OS, DSS, and DFS rates were 38, 58, and 27%, respectively. Independent predictors of poor OS and DSS were the paranasal sinuses as the primary tumor site [hazard ratio (HR) 1.73, 95% confidence interval (CI) 1.11–2.66; and HR 2.12, 95% CI 1.21–3.74, respectively] and the presence of distant metastases at presentation (HR 4.53, 95% CI 2.24–7.83; and HR 3.6, 95% CI 1.12–7.1). Recurrence occurred in 96 patients (48%). The most common cause of treatment failure was distant metastasis in 69 of 198 patients (35%), followed by local [36 (18%)] and regional [22 (11%)] recurrence.
Conclusion
The most common cause of treatment failure in SNMM is distant metastasis. The tumor site and the presence of metastatic disease at presentation were the only independent predictors of survival. These data can be used to inform quality improvement efforts and the counseling of high-risk SNMM patients.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-018-6465-y</identifier><identifier>PMID: 29626308</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Bone Neoplasms - secondary ; Brain Neoplasms - secondary ; Cancer ; Disease-Free Survival ; Female ; Head & neck cancer ; Head and neck ; Head and Neck Oncology ; Health risk assessment ; Humans ; Liver Neoplasms - secondary ; Lung Neoplasms - secondary ; Male ; Medicine ; Medicine & Public Health ; Melanoma ; Melanoma - secondary ; Melanoma - therapy ; Metastases ; Metastasis ; Middle Aged ; Mucosa ; Mucous Membrane ; Nasal Cavity ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local - pathology ; Neoplasm, Residual ; Nose ; Oncology ; Paranasal Sinus Neoplasms - pathology ; Paranasal Sinus Neoplasms - therapy ; Paranasal Sinuses ; Patients ; Quality control ; Retrospective Studies ; Sinus ; Surgery ; Surgical Oncology ; Survival ; Survival Rate ; Treatment Failure</subject><ispartof>Annals of surgical oncology, 2018-06, Vol.25 (6), p.1723-1729</ispartof><rights>Society of Surgical Oncology 2018</rights><rights>Annals of Surgical Oncology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-e4be0e834f7804e8c95f31d7cf4fac26e1e91cb5683a76db4b008abb300c19473</citedby><cites>FETCH-LOGICAL-c372t-e4be0e834f7804e8c95f31d7cf4fac26e1e91cb5683a76db4b008abb300c19473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-018-6465-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-018-6465-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29626308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amit, Moran</creatorcontrib><creatorcontrib>Tam, Samantha</creatorcontrib><creatorcontrib>Abdelmeguid, Ahmed S.</creatorcontrib><creatorcontrib>Kupferman, Michael E.</creatorcontrib><creatorcontrib>Su, Shirley Y.</creatorcontrib><creatorcontrib>Raza, Shaan M.</creatorcontrib><creatorcontrib>DeMonte, Franco</creatorcontrib><creatorcontrib>Hanna, Ehab Y.</creatorcontrib><title>Patterns of Treatment Failure in Patients with Sinonasal Mucosal Melanoma</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Head and neck mucosal melanoma is a locally aggressive tumor with a high recurrence rate. The paranasal sinuses and nasal cavity are the most common primary tumor sites.
Objective
The purpose of this retrospective study was to identify independent predictors of outcome in sinonasal mucosal melanoma (SNMM) and characterize the patterns of treatment failure.
Methods
This study included 198 patients with SNMM who had been treated at The University of Texas MD Anderson Cancer Center from 1 January 1991 through 31 December 2016. The survival outcomes included overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), local recurrence-free survival, and distant metastasis-free survival. A stepwise regression analysis was used to assess associations in the multivariate models.
Results
The 5-year OS, DSS, and DFS rates were 38, 58, and 27%, respectively. Independent predictors of poor OS and DSS were the paranasal sinuses as the primary tumor site [hazard ratio (HR) 1.73, 95% confidence interval (CI) 1.11–2.66; and HR 2.12, 95% CI 1.21–3.74, respectively] and the presence of distant metastases at presentation (HR 4.53, 95% CI 2.24–7.83; and HR 3.6, 95% CI 1.12–7.1). Recurrence occurred in 96 patients (48%). The most common cause of treatment failure was distant metastasis in 69 of 198 patients (35%), followed by local [36 (18%)] and regional [22 (11%)] recurrence.
Conclusion
The most common cause of treatment failure in SNMM is distant metastasis. The tumor site and the presence of metastatic disease at presentation were the only independent predictors of survival. These data can be used to inform quality improvement efforts and the counseling of high-risk SNMM patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bone Neoplasms - secondary</subject><subject>Brain Neoplasms - secondary</subject><subject>Cancer</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Head & neck cancer</subject><subject>Head and neck</subject><subject>Head and Neck Oncology</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Liver Neoplasms - secondary</subject><subject>Lung Neoplasms - secondary</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Melanoma</subject><subject>Melanoma - secondary</subject><subject>Melanoma - therapy</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mucosa</subject><subject>Mucous Membrane</subject><subject>Nasal Cavity</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm, Residual</subject><subject>Nose</subject><subject>Oncology</subject><subject>Paranasal Sinus Neoplasms - pathology</subject><subject>Paranasal Sinus Neoplasms - therapy</subject><subject>Paranasal Sinuses</subject><subject>Patients</subject><subject>Quality control</subject><subject>Retrospective Studies</subject><subject>Sinus</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>Treatment Failure</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1LAzEQhoMotlZ_gBcJePGymu_NHqVYLVQUrOeQTWd1y37UZBfpvzf9UEHwNGHyzDvDg9A5JdeUCXkTKBFcJITqRAklk_UBGlIZO0JpehjfROkkY0oO0EkIS0Joyok8RgOWKaY40UM0fbZdB74JuC3w3IPtamg6PLFl1XvAZYMjUMZWwJ9l945fyqZtbLAVfuxdu61Q2aat7Sk6KmwV4GxfR-h1cjcfPySzp_vp-HaWOJ6yLgGRAwHNRZFqIkC7TBacLlJXiMI6poBCRl0uleY2VYtc5IRom-ecEEczkfIRutrlrnz70UPoTF0GB1W8Ato-GEYYy1Kt2Aa9_IMu29438botJaSSmkWK7ijn2xA8FGbly9r6taHEbDybnWcTPZuNZ7OOMxf75D6vYfEz8S02AmwHhPjVvIH_Xf1_6hf72YgW</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Amit, Moran</creator><creator>Tam, Samantha</creator><creator>Abdelmeguid, Ahmed S.</creator><creator>Kupferman, Michael E.</creator><creator>Su, Shirley Y.</creator><creator>Raza, Shaan M.</creator><creator>DeMonte, Franco</creator><creator>Hanna, Ehab Y.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180601</creationdate><title>Patterns of Treatment Failure in Patients with Sinonasal Mucosal Melanoma</title><author>Amit, Moran ; Tam, Samantha ; Abdelmeguid, Ahmed S. ; Kupferman, Michael E. ; Su, Shirley Y. ; Raza, Shaan M. ; DeMonte, Franco ; Hanna, Ehab Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-e4be0e834f7804e8c95f31d7cf4fac26e1e91cb5683a76db4b008abb300c19473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bone Neoplasms - secondary</topic><topic>Brain Neoplasms - secondary</topic><topic>Cancer</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Head & neck cancer</topic><topic>Head and neck</topic><topic>Head and Neck Oncology</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Liver Neoplasms - secondary</topic><topic>Lung Neoplasms - secondary</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Melanoma</topic><topic>Melanoma - secondary</topic><topic>Melanoma - therapy</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Mucosa</topic><topic>Mucous Membrane</topic><topic>Nasal Cavity</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm, Residual</topic><topic>Nose</topic><topic>Oncology</topic><topic>Paranasal Sinus Neoplasms - pathology</topic><topic>Paranasal Sinus Neoplasms - therapy</topic><topic>Paranasal Sinuses</topic><topic>Patients</topic><topic>Quality control</topic><topic>Retrospective Studies</topic><topic>Sinus</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival</topic><topic>Survival Rate</topic><topic>Treatment Failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amit, Moran</creatorcontrib><creatorcontrib>Tam, Samantha</creatorcontrib><creatorcontrib>Abdelmeguid, Ahmed S.</creatorcontrib><creatorcontrib>Kupferman, Michael E.</creatorcontrib><creatorcontrib>Su, Shirley Y.</creatorcontrib><creatorcontrib>Raza, Shaan M.</creatorcontrib><creatorcontrib>DeMonte, Franco</creatorcontrib><creatorcontrib>Hanna, Ehab Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amit, Moran</au><au>Tam, Samantha</au><au>Abdelmeguid, Ahmed S.</au><au>Kupferman, Michael E.</au><au>Su, Shirley Y.</au><au>Raza, Shaan M.</au><au>DeMonte, Franco</au><au>Hanna, Ehab Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns of Treatment Failure in Patients with Sinonasal Mucosal Melanoma</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2018-06-01</date><risdate>2018</risdate><volume>25</volume><issue>6</issue><spage>1723</spage><epage>1729</epage><pages>1723-1729</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Head and neck mucosal melanoma is a locally aggressive tumor with a high recurrence rate. The paranasal sinuses and nasal cavity are the most common primary tumor sites.
Objective
The purpose of this retrospective study was to identify independent predictors of outcome in sinonasal mucosal melanoma (SNMM) and characterize the patterns of treatment failure.
Methods
This study included 198 patients with SNMM who had been treated at The University of Texas MD Anderson Cancer Center from 1 January 1991 through 31 December 2016. The survival outcomes included overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), local recurrence-free survival, and distant metastasis-free survival. A stepwise regression analysis was used to assess associations in the multivariate models.
Results
The 5-year OS, DSS, and DFS rates were 38, 58, and 27%, respectively. Independent predictors of poor OS and DSS were the paranasal sinuses as the primary tumor site [hazard ratio (HR) 1.73, 95% confidence interval (CI) 1.11–2.66; and HR 2.12, 95% CI 1.21–3.74, respectively] and the presence of distant metastases at presentation (HR 4.53, 95% CI 2.24–7.83; and HR 3.6, 95% CI 1.12–7.1). Recurrence occurred in 96 patients (48%). The most common cause of treatment failure was distant metastasis in 69 of 198 patients (35%), followed by local [36 (18%)] and regional [22 (11%)] recurrence.
Conclusion
The most common cause of treatment failure in SNMM is distant metastasis. The tumor site and the presence of metastatic disease at presentation were the only independent predictors of survival. These data can be used to inform quality improvement efforts and the counseling of high-risk SNMM patients.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>29626308</pmid><doi>10.1245/s10434-018-6465-y</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Bone Neoplasms - secondary Brain Neoplasms - secondary Cancer Disease-Free Survival Female Head & neck cancer Head and neck Head and Neck Oncology Health risk assessment Humans Liver Neoplasms - secondary Lung Neoplasms - secondary Male Medicine Medicine & Public Health Melanoma Melanoma - secondary Melanoma - therapy Metastases Metastasis Middle Aged Mucosa Mucous Membrane Nasal Cavity Neoplasm Invasiveness Neoplasm Recurrence, Local - pathology Neoplasm, Residual Nose Oncology Paranasal Sinus Neoplasms - pathology Paranasal Sinus Neoplasms - therapy Paranasal Sinuses Patients Quality control Retrospective Studies Sinus Surgery Surgical Oncology Survival Survival Rate Treatment Failure |
| title | Patterns of Treatment Failure in Patients with Sinonasal Mucosal Melanoma |
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