Na super(+)-mediated coupling between AMPA receptors and K sub(Na) channels shapes synaptic transmission

Na super(+)-mediated coupling between AMPA receptors and K sub(Na) channels shapes synaptic transmission

Na super(+)-activated K super(+) (K sub(Na)) channels are expressed in neurons and are activated by Na super(+) influx through voltage-dependent channels or ionotropic receptors, yet their function remains unclear. Here we show that K sub(Na) channels are associated with AMPA receptors and that thei...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2008-12, Vol.105 (52), p.20941-20946
Hauptverfasser: Nanou, Evanthia, Kyriakatos, Alexandros, Bhattacharjee, Arin, Kaczmarek, Leonard K, Paratcha, Gustavo, El Manira, Abdeljabbar
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container_issue 52
container_start_page 20941
container_title Proceedings of the National Academy of Sciences - PNAS
container_volume 105
creator Nanou, Evanthia
Kyriakatos, Alexandros
Bhattacharjee, Arin
Kaczmarek, Leonard K
Paratcha, Gustavo
El Manira, Abdeljabbar
description Na super(+)-activated K super(+) (K sub(Na)) channels are expressed in neurons and are activated by Na super(+) influx through voltage-dependent channels or ionotropic receptors, yet their function remains unclear. Here we show that K sub(Na) channels are associated with AMPA receptors and that their activation depresses synaptic responses. Synaptic activation of K sub(Na) channels by Na super(+) transients via AMPA receptors shapes the decay of AMPA-mediated current as well as the amplitude of the synaptic potential. Thus, the coupling between K sub(Na) channels and AMPA receptors by synaptically induced Na super(+) transients represents an inherent negative feedback mechanism that scales down the magnitude of excitatory synaptic responses.
doi_str_mv 10.1073/pnas.0806403106
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title Na super(+)-mediated coupling between AMPA receptors and K sub(Na) channels shapes synaptic transmission
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