Histone H3 lysine 9 acetylation pattern suggests that X and B chromosomes are silenced during entire male meiosis in a grasshopper
The facultative heterochromatic X chromosome in leptotene spermatocytes of the grasshopper Eyprepocnemis plorans showed marked hypoacetylation for lysine 9 in the H3 histone (H3-K9) with no sign of histone H2AX phosphorylation. Since H3-K9 hypoacetylation precedes the meiotic appearance of phosphory...
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| Veröffentlicht in: | Cytogenetic and genome research 2007-12, Vol.119 (1-2), p.135-142 |
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| creator | Cabrero, J. Teruel, M. Carmona, F.D. Jiménez, R. Camacho, J.P.M. |
| description | The facultative heterochromatic X chromosome in leptotene spermatocytes of the grasshopper Eyprepocnemis plorans showed marked hypoacetylation for lysine 9 in the H3 histone (H3-K9) with no sign of histone H2AX phosphorylation. Since H3-K9 hypoacetylation precedes the meiotic appearance of phosphorylated H2AX (γ-H2AX), which marks the beginning of recombinational DNA double-strand breaks (DSBs), it seems that meiotic sex-chromosome inactivation (MSCI) in this grasshopper occurs prior to the beginning of recombination and hence synapsis (which in this species begins later than recombination). In addition, all constitutively heterochromatic chromosome regions harbouring a 180-bp tandem-repeat DNA and rDNA (B chromosomes and pericentromeric regions of A chromosomes) were H3-K9 hypoacetylated at early leptotene even though they will synapse at subsequent stages. This also suggests that meiotic silencing in this grasshopper might be independent of synapsis. The H3-K9 hypoacetylated state of facultative and constitutive heterochromatin persisted during subsequent meiotic stages and was even apparent in round spermatids. Finally, the fact that B chromosomes are differentially hypoacetylated in testis and embryo interphase cells suggests that they might be silenced early in development and remain this way for most (or all) life-cycle stages. |
| doi_str_mv | 10.1159/000109630 |
| format | Article |
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Since H3-K9 hypoacetylation precedes the meiotic appearance of phosphorylated H2AX (γ-H2AX), which marks the beginning of recombinational DNA double-strand breaks (DSBs), it seems that meiotic sex-chromosome inactivation (MSCI) in this grasshopper occurs prior to the beginning of recombination and hence synapsis (which in this species begins later than recombination). In addition, all constitutively heterochromatic chromosome regions harbouring a 180-bp tandem-repeat DNA and rDNA (B chromosomes and pericentromeric regions of A chromosomes) were H3-K9 hypoacetylated at early leptotene even though they will synapse at subsequent stages. This also suggests that meiotic silencing in this grasshopper might be independent of synapsis. The H3-K9 hypoacetylated state of facultative and constitutive heterochromatin persisted during subsequent meiotic stages and was even apparent in round spermatids. Finally, the fact that B chromosomes are differentially hypoacetylated in testis and embryo interphase cells suggests that they might be silenced early in development and remain this way for most (or all) life-cycle stages.</description><identifier>ISSN: 1424-8581</identifier><identifier>EISSN: 1424-859X</identifier><identifier>DOI: 10.1159/000109630</identifier><identifier>PMID: 18160793</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Acetylation ; Animals ; Cells, Cultured ; Chromatin - genetics ; Chromosomes - genetics ; Eyprepocnemis plorans ; Gene Silencing ; Grasshoppers - cytology ; Grasshoppers - genetics ; Grasshoppers - metabolism ; Histones - chemistry ; Histones - metabolism ; Lysine - metabolism ; Male ; Meiosis - genetics ; Mice ; Original Article</subject><ispartof>Cytogenetic and genome research, 2007-12, Vol.119 (1-2), p.135-142</ispartof><rights>2007 S. Karger AG, Basel</rights><rights>Copyright (c) 2007 S. 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Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-5c412df1222e37448eb71a83ed94705150596df0c3f3ae83394e64c79e55d0823</citedby><cites>FETCH-LOGICAL-c424t-5c412df1222e37448eb71a83ed94705150596df0c3f3ae83394e64c79e55d0823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18160793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cabrero, J.</creatorcontrib><creatorcontrib>Teruel, M.</creatorcontrib><creatorcontrib>Carmona, F.D.</creatorcontrib><creatorcontrib>Jiménez, R.</creatorcontrib><creatorcontrib>Camacho, J.P.M.</creatorcontrib><title>Histone H3 lysine 9 acetylation pattern suggests that X and B chromosomes are silenced during entire male meiosis in a grasshopper</title><title>Cytogenetic and genome research</title><addtitle>Cytogenet Genome Res</addtitle><description>The facultative heterochromatic X chromosome in leptotene spermatocytes of the grasshopper Eyprepocnemis plorans showed marked hypoacetylation for lysine 9 in the H3 histone (H3-K9) with no sign of histone H2AX phosphorylation. 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Finally, the fact that B chromosomes are differentially hypoacetylated in testis and embryo interphase cells suggests that they might be silenced early in development and remain this way for most (or all) life-cycle stages.</description><subject>Acetylation</subject><subject>Animals</subject><subject>Cells, Cultured</subject><subject>Chromatin - genetics</subject><subject>Chromosomes - genetics</subject><subject>Eyprepocnemis plorans</subject><subject>Gene Silencing</subject><subject>Grasshoppers - cytology</subject><subject>Grasshoppers - genetics</subject><subject>Grasshoppers - metabolism</subject><subject>Histones - chemistry</subject><subject>Histones - metabolism</subject><subject>Lysine - metabolism</subject><subject>Male</subject><subject>Meiosis - genetics</subject><subject>Mice</subject><subject>Original Article</subject><issn>1424-8581</issn><issn>1424-859X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqN0s9rFDEUB_Agiq3Vg3eR4EHwsJrfkxxrUVcoeFHobUhn3symziRjXuawV_9yU3ep4qVekkf45BteeIQ85-wt59q9Y4xx5oxkD8gpV0JtrHZXD-9qy0_IE8SbqqzS5jE54ZYb1jh5Sn5uA5YUgW4lnfYYauWo76DsJ19CinTxpUCOFNdxBCxIy84XekV97Ol72u1ymhOmGZD6DBTDBLGDnvZrDnGkEEuox7Of6gIhYUAaIvV0zB5xl5YF8lPyaPATwrPjfka-ffzw9WK7ufzy6fPF-eWmq22Uje4UF_3AhRAgG6UsXDfcWwm9Uw3TXDPtTD-wTg7Sg5XSKTCqaxxo3TMr5Bl5fchdcvqx1l7aOWAH0-QjpBVb46pqrLoXCl6Z0OZ-yByvVv4HFMIadfv0q3_gTVpzrN_SCqEEZ0boit4cUJcTYoahXXKYfd63nLW3A9HeDUS1L4-B6_UM_R95nIAKXhzAd59HyH9F_b7_C7wMt7o</recordid><startdate>200712</startdate><enddate>200712</enddate><creator>Cabrero, J.</creator><creator>Teruel, M.</creator><creator>Carmona, F.D.</creator><creator>Jiménez, R.</creator><creator>Camacho, J.P.M.</creator><general>S. 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Since H3-K9 hypoacetylation precedes the meiotic appearance of phosphorylated H2AX (γ-H2AX), which marks the beginning of recombinational DNA double-strand breaks (DSBs), it seems that meiotic sex-chromosome inactivation (MSCI) in this grasshopper occurs prior to the beginning of recombination and hence synapsis (which in this species begins later than recombination). In addition, all constitutively heterochromatic chromosome regions harbouring a 180-bp tandem-repeat DNA and rDNA (B chromosomes and pericentromeric regions of A chromosomes) were H3-K9 hypoacetylated at early leptotene even though they will synapse at subsequent stages. This also suggests that meiotic silencing in this grasshopper might be independent of synapsis. The H3-K9 hypoacetylated state of facultative and constitutive heterochromatin persisted during subsequent meiotic stages and was even apparent in round spermatids. Finally, the fact that B chromosomes are differentially hypoacetylated in testis and embryo interphase cells suggests that they might be silenced early in development and remain this way for most (or all) life-cycle stages.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>18160793</pmid><doi>10.1159/000109630</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Karger Journals; Alma/SFX Local Collection |
| subjects | Acetylation Animals Cells, Cultured Chromatin - genetics Chromosomes - genetics Eyprepocnemis plorans Gene Silencing Grasshoppers - cytology Grasshoppers - genetics Grasshoppers - metabolism Histones - chemistry Histones - metabolism Lysine - metabolism Male Meiosis - genetics Mice Original Article |
| title | Histone H3 lysine 9 acetylation pattern suggests that X and B chromosomes are silenced during entire male meiosis in a grasshopper |
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