Polychlorinated biphenyl mixtures (Aroclors) induce apoptosis via Bcl-2, Bax and caspase-3 proteins in neuronal cell cultures

Polychlorinated biphenyls (PCBs) are a group of persistent and widely dispersed environmental pollutants, some of which may be neurotoxic. In the present study, we have investigated the effect of PCB commercial mixtures (Aroclors) on neuronal cell cultures by assessing cell viability and apoptotic c...

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Veröffentlicht in:	Toxicology letters 2004-11, Vol.153 (3), p.311-326
Hauptverfasser:	Sánchez-Alonso, Jesús Adolfo, López-Aparicio, Pilar, Recio, Marı́a N., Pérez-Albarsanz, Miguel A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Aroclors Aroclors - toxicity Bcl-2 bcl-2-Associated X Protein Biological and medical sciences Blotting, Western Caspase 3 Caspases Caspases - physiology Cell Nucleus - drug effects Cell Nucleus - metabolism Cell Nucleus - ultrastructure Cell Survival - drug effects Cells, Cultured Cytotoxicity DNA Damage - drug effects DNA Fragmentation - drug effects Dose-Response Relationship, Drug Environmental Pollutants - toxicity L-Lactate Dehydrogenase - metabolism Medical sciences Microscopy, Fluorescence Neuronal cell cultures Neurons - drug effects Nucleosomes - drug effects Polychlorinated biphenyls Proto-Oncogene Proteins c-bcl-2 - physiology Rats Toxicology
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