Neuroimaging of the dopamine transporter in Parkinsons disease: first study using [ super(99m)Tc]-TRODAT-1 and SPECT in Brazil
BACKGROUND: Dopamine transporter (DAT) neuroimaging radiotracers were developed to estimate dopamine neuronal loss In vivo in Parkinsons disease (PD). OBJECTIVE: To evaluate DAT density in vivo using [ super(99m)Tc]-TRODAT-1 and single photon computerized tomography (SPECT) in a population of Brazil...
Gespeichert in:
| Veröffentlicht in: | Arquivos de neuro-psiquiatria 2006-09, Vol.64 (2b), p.628-634 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng ; por |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 634 |
|---|---|
| container_issue | 2b |
| container_start_page | 628 |
| container_title | Arquivos de neuro-psiquiatria |
| container_volume | 64 |
| creator | Shih, M C |
| description | BACKGROUND: Dopamine transporter (DAT) neuroimaging radiotracers were developed to estimate dopamine neuronal loss In vivo in Parkinsons disease (PD). OBJECTIVE: To evaluate DAT density in vivo using [ super(99m)Tc]-TRODAT-1 and single photon computerized tomography (SPECT) in a population of Brazilian PD. METHOD: Fifteen PD patients and 15 matched healthy controls scanned with [ super(99m)Tc]-TRODAT-1 (INER-Taiwan) and SPECT. Estimates of striatum DAT density were calculated using binding potential (BP). Patients were assessed with PD scales. RESULTS: PD patients had significantly lower striatal DAT-BP (mean plus or minus SD) (0.38 plus or minus 0.12) compared to controls (BP=0.84 plus or minus 0.16; p |
| doi_str_mv | 10.1590/S0004-282X2006000400021 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_20227715</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20227715</sourcerecordid><originalsourceid>FETCH-LOGICAL-p116t-2f66bd5d3674a41363facba29f1139b332d1ac229fae697ff87944db88cfa1403</originalsourceid><addsrcrecordid>eNo9jM1Kw0AYRWehYK0-g7MSXUTnJ00y7mqtP1BssREEkfIlM1NHk0mcL1nowme3RXFxuZx74RByxNkZHyl2vmSMxZHIxJNgLNnCJoLvkMH_sUf2Ed82a6xUOiDf96YPjath7fyaNpZ2r4bqpoXaeUO7AB7bJnQmUOfpAsK789h4pNqhATQX1LqAHcWu15-0x63kmWLfmnCiVH2aly9R_jC_GucRp-A1XS6mk3zrugzw5aoDsmuhQnP410PyeD3NJ7fRbH5zNxnPopbzpIuETZJCj7RM0hhiLhNpoSxAKMu5VIWUQnMoxYbBJCq1NktVHOsiy0oLPGZySI5_vW1oPnqD3ap2WJqqAm-aHleCCZGmfCR_ANcWYaI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20227715</pqid></control><display><type>article</type><title>Neuroimaging of the dopamine transporter in Parkinsons disease: first study using [ super(99m)Tc]-TRODAT-1 and SPECT in Brazil</title><source>Directory of Open Access Journals</source><source>EZB Electronic Journals Library</source><creator>Shih, M C</creator><creatorcontrib>Shih, M C</creatorcontrib><description>BACKGROUND: Dopamine transporter (DAT) neuroimaging radiotracers were developed to estimate dopamine neuronal loss In vivo in Parkinsons disease (PD). OBJECTIVE: To evaluate DAT density in vivo using [ super(99m)Tc]-TRODAT-1 and single photon computerized tomography (SPECT) in a population of Brazilian PD. METHOD: Fifteen PD patients and 15 matched healthy controls scanned with [ super(99m)Tc]-TRODAT-1 (INER-Taiwan) and SPECT. Estimates of striatum DAT density were calculated using binding potential (BP). Patients were assessed with PD scales. RESULTS: PD patients had significantly lower striatal DAT-BP (mean plus or minus SD) (0.38 plus or minus 0.12) compared to controls (BP=0.84 plus or minus 0.16; p<0.01). A 100% sensitivity and 100% specificity was obtained to discriminate PD cases from controls. Negative correlations between striatal DAT-BP and PD severity (rho= -0.7, p<0.001) and motor scales (rho= -0.80, p<0.001) were found. CONCLUSION: [ super(99m)Tc]TRODAT-1 SPECTs scanning was able to discriminate PD patients from controls. The technique is a powerful instrument to measure DAT density that can be used in clinical and research settings in Brazil.</description><identifier>ISSN: 0004-282X</identifier><identifier>DOI: 10.1590/S0004-282X2006000400021</identifier><language>eng ; por</language><ispartof>Arquivos de neuro-psiquiatria, 2006-09, Vol.64 (2b), p.628-634</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Shih, M C</creatorcontrib><title>Neuroimaging of the dopamine transporter in Parkinsons disease: first study using [ super(99m)Tc]-TRODAT-1 and SPECT in Brazil</title><title>Arquivos de neuro-psiquiatria</title><description>BACKGROUND: Dopamine transporter (DAT) neuroimaging radiotracers were developed to estimate dopamine neuronal loss In vivo in Parkinsons disease (PD). OBJECTIVE: To evaluate DAT density in vivo using [ super(99m)Tc]-TRODAT-1 and single photon computerized tomography (SPECT) in a population of Brazilian PD. METHOD: Fifteen PD patients and 15 matched healthy controls scanned with [ super(99m)Tc]-TRODAT-1 (INER-Taiwan) and SPECT. Estimates of striatum DAT density were calculated using binding potential (BP). Patients were assessed with PD scales. RESULTS: PD patients had significantly lower striatal DAT-BP (mean plus or minus SD) (0.38 plus or minus 0.12) compared to controls (BP=0.84 plus or minus 0.16; p<0.01). A 100% sensitivity and 100% specificity was obtained to discriminate PD cases from controls. Negative correlations between striatal DAT-BP and PD severity (rho= -0.7, p<0.001) and motor scales (rho= -0.80, p<0.001) were found. CONCLUSION: [ super(99m)Tc]TRODAT-1 SPECTs scanning was able to discriminate PD patients from controls. The technique is a powerful instrument to measure DAT density that can be used in clinical and research settings in Brazil.</description><issn>0004-282X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNo9jM1Kw0AYRWehYK0-g7MSXUTnJ00y7mqtP1BssREEkfIlM1NHk0mcL1nowme3RXFxuZx74RByxNkZHyl2vmSMxZHIxJNgLNnCJoLvkMH_sUf2Ed82a6xUOiDf96YPjath7fyaNpZ2r4bqpoXaeUO7AB7bJnQmUOfpAsK789h4pNqhATQX1LqAHcWu15-0x63kmWLfmnCiVH2aly9R_jC_GucRp-A1XS6mk3zrugzw5aoDsmuhQnP410PyeD3NJ7fRbH5zNxnPopbzpIuETZJCj7RM0hhiLhNpoSxAKMu5VIWUQnMoxYbBJCq1NktVHOsiy0oLPGZySI5_vW1oPnqD3ap2WJqqAm-aHleCCZGmfCR_ANcWYaI</recordid><startdate>20060901</startdate><enddate>20060901</enddate><creator>Shih, M C</creator><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20060901</creationdate><title>Neuroimaging of the dopamine transporter in Parkinsons disease: first study using [ super(99m)Tc]-TRODAT-1 and SPECT in Brazil</title><author>Shih, M C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p116t-2f66bd5d3674a41363facba29f1139b332d1ac229fae697ff87944db88cfa1403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; por</language><creationdate>2006</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shih, M C</creatorcontrib><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Arquivos de neuro-psiquiatria</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shih, M C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroimaging of the dopamine transporter in Parkinsons disease: first study using [ super(99m)Tc]-TRODAT-1 and SPECT in Brazil</atitle><jtitle>Arquivos de neuro-psiquiatria</jtitle><date>2006-09-01</date><risdate>2006</risdate><volume>64</volume><issue>2b</issue><spage>628</spage><epage>634</epage><pages>628-634</pages><issn>0004-282X</issn><abstract>BACKGROUND: Dopamine transporter (DAT) neuroimaging radiotracers were developed to estimate dopamine neuronal loss In vivo in Parkinsons disease (PD). OBJECTIVE: To evaluate DAT density in vivo using [ super(99m)Tc]-TRODAT-1 and single photon computerized tomography (SPECT) in a population of Brazilian PD. METHOD: Fifteen PD patients and 15 matched healthy controls scanned with [ super(99m)Tc]-TRODAT-1 (INER-Taiwan) and SPECT. Estimates of striatum DAT density were calculated using binding potential (BP). Patients were assessed with PD scales. RESULTS: PD patients had significantly lower striatal DAT-BP (mean plus or minus SD) (0.38 plus or minus 0.12) compared to controls (BP=0.84 plus or minus 0.16; p<0.01). A 100% sensitivity and 100% specificity was obtained to discriminate PD cases from controls. Negative correlations between striatal DAT-BP and PD severity (rho= -0.7, p<0.001) and motor scales (rho= -0.80, p<0.001) were found. CONCLUSION: [ super(99m)Tc]TRODAT-1 SPECTs scanning was able to discriminate PD patients from controls. The technique is a powerful instrument to measure DAT density that can be used in clinical and research settings in Brazil.</abstract><doi>10.1590/S0004-282X2006000400021</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0004-282X |
| ispartof | Arquivos de neuro-psiquiatria, 2006-09, Vol.64 (2b), p.628-634 |
| issn | 0004-282X |
| language | eng ; por |
| recordid | cdi_proquest_miscellaneous_20227715 |
| source | Directory of Open Access Journals; EZB Electronic Journals Library |
| title | Neuroimaging of the dopamine transporter in Parkinsons disease: first study using [ super(99m)Tc]-TRODAT-1 and SPECT in Brazil |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T19%3A43%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neuroimaging%20of%20the%20dopamine%20transporter%20in%20Parkinsons%20disease:%20first%20study%20using%20%5B%20super(99m)Tc%5D-TRODAT-1%20and%20SPECT%20in%20Brazil&rft.jtitle=Arquivos%20de%20neuro-psiquiatria&rft.au=Shih,%20M%20C&rft.date=2006-09-01&rft.volume=64&rft.issue=2b&rft.spage=628&rft.epage=634&rft.pages=628-634&rft.issn=0004-282X&rft_id=info:doi/10.1590/S0004-282X2006000400021&rft_dat=%3Cproquest%3E20227715%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20227715&rft_id=info:pmid/&rfr_iscdi=true |