Helicobacter pylori cag pathogenicity island-positive strains induce syndecan-4 expression in gastric epithelial cells

Abstract Helicobacter pylori is recognized as the main cause of gastritis and is associated with gastric carcinogenesis. Syndecan-4 represents the major source of heparan sulfate (HS) in the gastric cells. HS proteoglycans expressed on the cell surface constitute targets for H. pylori at the early s...

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Veröffentlicht in:	FEMS immunology and medical microbiology 2009-08, Vol.56 (3), p.223-232
Hauptverfasser:	Magalhães, Ana, Marcos, Nuno T., Carvalho, Ana S., David, Leonor, Figueiredo, Céu, Bastos, Joana, David, Guido, Reis, Celso A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Bacterial - genetics Bacterial Adhesion Bacterial Proteins - genetics Bacteriology Biological and medical sciences Biotechnology cag pathogenicity island Carcinogenesis Carcinogens Cell lines Cell surface Cytotoxicity Epithelial cells Epithelial Cells - microbiology Epithelium Fundamental and applied biological sciences. Psychology gastric disease Gastric mucosa Gastric Mucosa - pathology Gastritis Gene Expression Profiling Genomic Islands Helicobacter pylori Helicobacter pylori - genetics Helicobacter pylori - pathogenicity Heparan sulfate Humans Infections Microbiology Miscellaneous Pathogenicity Pathogens Proteoglycans Syndecan Syndecan-4 - biosynthesis syndecan‐4 Trinucleotide repeats Virulence
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