A benzylic linker promotes methyltransferase catalyzed norbornene transfer for rapid bioorthogonal tetrazine ligation

Site-specific alkylation of complex biomolecules is critical for late-stage product diversification as well as post-synthetic labeling and manipulation of proteins and nucleic acids. Promiscuous methyltransferases in combination with analogs of S -adenosyl- l -methionine (AdoMet) can functionalize a...

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Veröffentlicht in:	Chemical science (Cambridge) 2017-12, Vol.8 (12), p.7947-7953
Hauptverfasser:	Muttach, F, Muthmann, N, Reichert, D, Anhäuser, L, Rentmeister, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Biocompatibility Biomolecules Catalysis Chemistry Deoxyribonucleic acid DNA Methionine Nucleic acids Proteins Ribonucleic acid RNA
Online-Zugang:	Volltext
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