Granuloma formation in the liver is relatively delayed, although sustained, in BCG‑infected mice co‑infected with Plasmodium
The purpose of the present study was to examine the effects of Plasmodium on the process of granuloma formation in Bacille Calmette‑Guerin (BCG)‑infected mice. Female six‑week‑old BALB/c mice were co‑infected with BCG and Plasmodium. The liver index, pathological alterations and quantity of granulom...
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| Veröffentlicht in: | Molecular medicine reports 2018-06, Vol.17 (6), p.7764-7768 |
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| creator | Nashun, Bayaer You, Jianlan Ji, Musi Zhao, Siting Qin, Li Chen, Xiaoping |
| description | The purpose of the present study was to examine the effects of Plasmodium on the process of granuloma formation in Bacille Calmette‑Guerin (BCG)‑infected mice. Female six‑week‑old BALB/c mice were co‑infected with BCG and Plasmodium. The liver index, pathological alterations and quantity of granulomas in the mice were observed when the mice were co‑injected with BCG and Plasmodium. The expression of inducible nitric oxide synthase (iNOS) was assessed by immunohistochemistry and reverse transcription‑polymerase chain reaction (RT‑PCR) analysis. In addition, the expression of interleukin (IL)‑10 in liver tissues was observed by RT‑PCR. Following co‑infection with BCG and Plasmodium, the swelling of the liver had been slowly restored to normal, and the time required to allow granulomas to subside had prolonged. In addition, the expression of iNOS increased, while the expression of IL‑10 gradually decreased in Plasmodium‑infected mice. It was concluded that the use of Plasmodium relatively delayed granuloma formation in livers of BCG‑infected mice. In addition, iNOS and IL‑10 are involved in this pathogenesis. |
| doi_str_mv | 10.3892/mmr.2018.8836 |
| format | Article |
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Female six‑week‑old BALB/c mice were co‑infected with BCG and Plasmodium. The liver index, pathological alterations and quantity of granulomas in the mice were observed when the mice were co‑injected with BCG and Plasmodium. The expression of inducible nitric oxide synthase (iNOS) was assessed by immunohistochemistry and reverse transcription‑polymerase chain reaction (RT‑PCR) analysis. In addition, the expression of interleukin (IL)‑10 in liver tissues was observed by RT‑PCR. Following co‑infection with BCG and Plasmodium, the swelling of the liver had been slowly restored to normal, and the time required to allow granulomas to subside had prolonged. In addition, the expression of iNOS increased, while the expression of IL‑10 gradually decreased in Plasmodium‑infected mice. It was concluded that the use of Plasmodium relatively delayed granuloma formation in livers of BCG‑infected mice. In addition, iNOS and IL‑10 are involved in this pathogenesis.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2018.8836</identifier><identifier>PMID: 29620231</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Animals ; Bacillus Calmette-Guerin vaccine ; Bacterial Load ; BCG ; Blood ; Care and treatment ; Cattle ; Coinfection ; Development and progression ; Disease Models, Animal ; Genetic aspects ; Granuloma ; Granuloma - metabolism ; Granuloma - microbiology ; Granuloma - pathology ; Granulomas ; Health aspects ; Hepatitis ; Humidity ; Immune response ; Immunohistochemistry ; Infections ; Interleukin 10 ; Interleukin-10 - metabolism ; Laboratories ; Liver ; Liver - metabolism ; Liver - microbiology ; Liver - pathology ; Malaria ; Malaria - parasitology ; Mice ; Mycobacterium bovis - physiology ; Nitric oxide ; Nitric Oxide Synthase Type II - metabolism ; Nitric-oxide synthase ; Plasmodium ; Plasmodium (Protozoa) ; Polymerase chain reaction ; Prevention ; Reverse transcription ; Rodents ; Statistical analysis ; Tuberculosis ; Tuberculosis, Bovine - metabolism ; Tuberculosis, Bovine - microbiology ; Tuberculosis, Bovine - pathology</subject><ispartof>Molecular medicine reports, 2018-06, Vol.17 (6), p.7764-7768</ispartof><rights>COPYRIGHT 2018 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c383t-f99730af0b26788e405cc7017355b85b82304e4b16aa990bfbc1f23088751dc93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29620231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nashun, Bayaer</creatorcontrib><creatorcontrib>You, Jianlan</creatorcontrib><creatorcontrib>Ji, Musi</creatorcontrib><creatorcontrib>Zhao, Siting</creatorcontrib><creatorcontrib>Qin, Li</creatorcontrib><creatorcontrib>Chen, Xiaoping</creatorcontrib><title>Granuloma formation in the liver is relatively delayed, although sustained, in BCG‑infected mice co‑infected with Plasmodium</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>The purpose of the present study was to examine the effects of Plasmodium on the process of granuloma formation in Bacille Calmette‑Guerin (BCG)‑infected mice. Female six‑week‑old BALB/c mice were co‑infected with BCG and Plasmodium. The liver index, pathological alterations and quantity of granulomas in the mice were observed when the mice were co‑injected with BCG and Plasmodium. The expression of inducible nitric oxide synthase (iNOS) was assessed by immunohistochemistry and reverse transcription‑polymerase chain reaction (RT‑PCR) analysis. In addition, the expression of interleukin (IL)‑10 in liver tissues was observed by RT‑PCR. Following co‑infection with BCG and Plasmodium, the swelling of the liver had been slowly restored to normal, and the time required to allow granulomas to subside had prolonged. In addition, the expression of iNOS increased, while the expression of IL‑10 gradually decreased in Plasmodium‑infected mice. It was concluded that the use of Plasmodium relatively delayed granuloma formation in livers of BCG‑infected mice. In addition, iNOS and IL‑10 are involved in this pathogenesis.</description><subject>Animals</subject><subject>Bacillus Calmette-Guerin vaccine</subject><subject>Bacterial Load</subject><subject>BCG</subject><subject>Blood</subject><subject>Care and treatment</subject><subject>Cattle</subject><subject>Coinfection</subject><subject>Development and progression</subject><subject>Disease Models, Animal</subject><subject>Genetic aspects</subject><subject>Granuloma</subject><subject>Granuloma - metabolism</subject><subject>Granuloma - microbiology</subject><subject>Granuloma - pathology</subject><subject>Granulomas</subject><subject>Health aspects</subject><subject>Hepatitis</subject><subject>Humidity</subject><subject>Immune response</subject><subject>Immunohistochemistry</subject><subject>Infections</subject><subject>Interleukin 10</subject><subject>Interleukin-10 - metabolism</subject><subject>Laboratories</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Liver - microbiology</subject><subject>Liver - pathology</subject><subject>Malaria</subject><subject>Malaria - parasitology</subject><subject>Mice</subject><subject>Mycobacterium bovis - physiology</subject><subject>Nitric oxide</subject><subject>Nitric Oxide Synthase Type II - metabolism</subject><subject>Nitric-oxide synthase</subject><subject>Plasmodium</subject><subject>Plasmodium (Protozoa)</subject><subject>Polymerase chain reaction</subject><subject>Prevention</subject><subject>Reverse transcription</subject><subject>Rodents</subject><subject>Statistical analysis</subject><subject>Tuberculosis</subject><subject>Tuberculosis, Bovine - metabolism</subject><subject>Tuberculosis, Bovine - microbiology</subject><subject>Tuberculosis, Bovine - pathology</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkU1v1DAQhi0EomXhyBVZ4tID2fojie1jWZUFqRI9wNlynEnXlR0XOynaW_9C_2J_CY66fArZkkevnxnNzIvQa0rWXCp2GkJaM0LlWkrePkHHVChacULqp4eYKSWO0IucrwlpG9ao5-iIqZYRxukxutsmM84-BoOHmIKZXByxG_G0A-zdLSTsMk7gy8ct-D3uS7iH_h02ftrF-WqH85wn48ZFK3nvN9uHu3s3DmAn6HFwFrCNf0rf3bTDl97kEHs3h5fo2WB8hleHd4W-fjj_svlYXXzeftqcXVSWSz5VQ5mCEzOQjrVCSqhJY60gVPCm6WS5jJMa6o62xihFuqGzdCialKKhvVV8hU4e696k-G2GPOngsgXvzQhxzrrsg1FOVFnjCr39B72OcxpLd4Xismm5FOo3dWU86DJenJKxS1F91tRUiLYUK9T6P1Q5PZTdxBEGV_S_EqrHBJtizgkGfZNcMGmvKdGL47o4rhfH9eJ44d8cmp27AP0v-qfF_AfTCqdP</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Nashun, Bayaer</creator><creator>You, Jianlan</creator><creator>Ji, Musi</creator><creator>Zhao, Siting</creator><creator>Qin, Li</creator><creator>Chen, Xiaoping</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180601</creationdate><title>Granuloma formation in the liver is relatively delayed, although sustained, in BCG‑infected mice co‑infected with Plasmodium</title><author>Nashun, Bayaer ; You, Jianlan ; Ji, Musi ; Zhao, Siting ; Qin, Li ; Chen, Xiaoping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-f99730af0b26788e405cc7017355b85b82304e4b16aa990bfbc1f23088751dc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Bacillus Calmette-Guerin vaccine</topic><topic>Bacterial Load</topic><topic>BCG</topic><topic>Blood</topic><topic>Care and treatment</topic><topic>Cattle</topic><topic>Coinfection</topic><topic>Development and progression</topic><topic>Disease Models, Animal</topic><topic>Genetic aspects</topic><topic>Granuloma</topic><topic>Granuloma - 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Academic</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nashun, Bayaer</au><au>You, Jianlan</au><au>Ji, Musi</au><au>Zhao, Siting</au><au>Qin, Li</au><au>Chen, Xiaoping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Granuloma formation in the liver is relatively delayed, although sustained, in BCG‑infected mice co‑infected with Plasmodium</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2018-06-01</date><risdate>2018</risdate><volume>17</volume><issue>6</issue><spage>7764</spage><epage>7768</epage><pages>7764-7768</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>The purpose of the present study was to examine the effects of Plasmodium on the process of granuloma formation in Bacille Calmette‑Guerin (BCG)‑infected mice. Female six‑week‑old BALB/c mice were co‑infected with BCG and Plasmodium. The liver index, pathological alterations and quantity of granulomas in the mice were observed when the mice were co‑injected with BCG and Plasmodium. The expression of inducible nitric oxide synthase (iNOS) was assessed by immunohistochemistry and reverse transcription‑polymerase chain reaction (RT‑PCR) analysis. In addition, the expression of interleukin (IL)‑10 in liver tissues was observed by RT‑PCR. Following co‑infection with BCG and Plasmodium, the swelling of the liver had been slowly restored to normal, and the time required to allow granulomas to subside had prolonged. In addition, the expression of iNOS increased, while the expression of IL‑10 gradually decreased in Plasmodium‑infected mice. It was concluded that the use of Plasmodium relatively delayed granuloma formation in livers of BCG‑infected mice. In addition, iNOS and IL‑10 are involved in this pathogenesis.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>29620231</pmid><doi>10.3892/mmr.2018.8836</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Bacillus Calmette-Guerin vaccine Bacterial Load BCG Blood Care and treatment Cattle Coinfection Development and progression Disease Models, Animal Genetic aspects Granuloma Granuloma - metabolism Granuloma - microbiology Granuloma - pathology Granulomas Health aspects Hepatitis Humidity Immune response Immunohistochemistry Infections Interleukin 10 Interleukin-10 - metabolism Laboratories Liver Liver - metabolism Liver - microbiology Liver - pathology Malaria Malaria - parasitology Mice Mycobacterium bovis - physiology Nitric oxide Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Plasmodium Plasmodium (Protozoa) Polymerase chain reaction Prevention Reverse transcription Rodents Statistical analysis Tuberculosis Tuberculosis, Bovine - metabolism Tuberculosis, Bovine - microbiology Tuberculosis, Bovine - pathology |
| title | Granuloma formation in the liver is relatively delayed, although sustained, in BCG‑infected mice co‑infected with Plasmodium |
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