Ovarian cancer therapeutic potential of glutamine depletion based on GS expression

In ovarian cancer (OVC) cells, the cell sensitivity to glutamine (Gln) depletion is inversely correlated with the glutamine synthetase (GS) expression. GS expression was downregulated in OVC cell lines and primary tumors. The pharmacological depletion of extracellular Gln led to the inhibition of ce...

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Veröffentlicht in:	Carcinogenesis (New York) 2018-05, Vol.39 (6), p.758-766
Hauptverfasser:	Furusawa, Akiko, Miyamoto, Morikazu, Takano, Masashi, Tsuda, Hitoshi, Song, Yong Sang, Aoki, Daisuke, Miyasaka, Naoyuki, Inazawa, Johji, Inoue, Jun
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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