Long noncoding RNA LINC00152 as a novel predictor of lymph node metastasis and survival in human cancer: a systematic review and meta-analysis
LINC00152, a novel long noncoding RNA (lncRNA), was identified as an oncogene involved various cancers. This study was designed to explore the clinical significance and prognosis role of LINC00152. Eligible studies were recruited by a systematic search in PubMed, Web of Science, and Embase up to Aug...
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| Veröffentlicht in: | Clinica chimica acta 2018-08, Vol.483, p.25-32 |
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| container_title | Clinica chimica acta |
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| creator | Zhang, Jiaming Yin, Minuo Huang, Junming Lv, Zhengtao Liang, Shuang Miao, Xiaoao Huang, Fang Zhao, Yingchao |
| description | LINC00152, a novel long noncoding RNA (lncRNA), was identified as an oncogene involved various cancers. This study was designed to explore the clinical significance and prognosis role of LINC00152.
Eligible studies were recruited by a systematic search in PubMed, Web of Science, and Embase up to August 23, 2017. Odds ratios (ORs), hazard ratios (HRs) and 95% confidence interval (95% CI) were pooled using Review Manager 5.3 and STATA 12.0.
A total of 10 studies with 913 patients were included to evaluate the association between LINC00152 expression and clinicopathological factors, overall survival (OS) and disease-free survivals (DFS). The results indicated that the expression level of LINC00152 was positively correlated with tumor size (OR = 5.19, 95% CI: 2.33–11.52, p |
| doi_str_mv | 10.1016/j.cca.2018.03.034 |
| format | Article |
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Eligible studies were recruited by a systematic search in PubMed, Web of Science, and Embase up to August 23, 2017. Odds ratios (ORs), hazard ratios (HRs) and 95% confidence interval (95% CI) were pooled using Review Manager 5.3 and STATA 12.0.
A total of 10 studies with 913 patients were included to evaluate the association between LINC00152 expression and clinicopathological factors, overall survival (OS) and disease-free survivals (DFS). The results indicated that the expression level of LINC00152 was positively correlated with tumor size (OR = 5.19, 95% CI: 2.33–11.52, p < .0001), TNM stage (OR = 3.12, 95% CI: 1.77–5.51, p < .0001) and lymph node metastasis (OR = 3.41, 95% CI: 2.13–5.48, p < .00001). Moreover, elevated LINC00152 could predict unfavorable OS with pooled HR of 1.66 (95% CI: 1.29–2.13, p < .0001) and poor DFS (HR = 2.13, 95% CI: 1.39–3.25, p = .0005) in cancer patients.
LINC00152 was correlated with advanced clinicopathological features and poor prognosis as a novel predictive biomarker in various cancers.
•It has been reported that LINC00152 was dysregulated in different cancers. This study was designed to explore the clinical significance and prognosis role of LINC00152.•The expression level of LINC00152 was positively correlated with tumor size, TNM stage and lymph node metastasis.•Elevated LINC00152 could predict unfavorable overall survival and poor disease-free survival in cancer patients.•This meta-analysis demonstrated that LINC00152 was correlated with advanced clinicopathological features and poor prognosis as a novel predictive biomarker in various cancers.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/j.cca.2018.03.034</identifier><identifier>PMID: 29617624</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Cancer ; LINC00152 ; lncRNA ; Meta-analysis ; Prognosis</subject><ispartof>Clinica chimica acta, 2018-08, Vol.483, p.25-32</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-3b6bdbc0e79c3ec5acca558505df569c37fccb490e10940f7abaffe8461fd0ce3</citedby><cites>FETCH-LOGICAL-c353t-3b6bdbc0e79c3ec5acca558505df569c37fccb490e10940f7abaffe8461fd0ce3</cites><orcidid>0000-0001-8520-566X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009898118301505$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29617624$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Jiaming</creatorcontrib><creatorcontrib>Yin, Minuo</creatorcontrib><creatorcontrib>Huang, Junming</creatorcontrib><creatorcontrib>Lv, Zhengtao</creatorcontrib><creatorcontrib>Liang, Shuang</creatorcontrib><creatorcontrib>Miao, Xiaoao</creatorcontrib><creatorcontrib>Huang, Fang</creatorcontrib><creatorcontrib>Zhao, Yingchao</creatorcontrib><title>Long noncoding RNA LINC00152 as a novel predictor of lymph node metastasis and survival in human cancer: a systematic review and meta-analysis</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>LINC00152, a novel long noncoding RNA (lncRNA), was identified as an oncogene involved various cancers. This study was designed to explore the clinical significance and prognosis role of LINC00152.
Eligible studies were recruited by a systematic search in PubMed, Web of Science, and Embase up to August 23, 2017. Odds ratios (ORs), hazard ratios (HRs) and 95% confidence interval (95% CI) were pooled using Review Manager 5.3 and STATA 12.0.
A total of 10 studies with 913 patients were included to evaluate the association between LINC00152 expression and clinicopathological factors, overall survival (OS) and disease-free survivals (DFS). The results indicated that the expression level of LINC00152 was positively correlated with tumor size (OR = 5.19, 95% CI: 2.33–11.52, p < .0001), TNM stage (OR = 3.12, 95% CI: 1.77–5.51, p < .0001) and lymph node metastasis (OR = 3.41, 95% CI: 2.13–5.48, p < .00001). Moreover, elevated LINC00152 could predict unfavorable OS with pooled HR of 1.66 (95% CI: 1.29–2.13, p < .0001) and poor DFS (HR = 2.13, 95% CI: 1.39–3.25, p = .0005) in cancer patients.
LINC00152 was correlated with advanced clinicopathological features and poor prognosis as a novel predictive biomarker in various cancers.
•It has been reported that LINC00152 was dysregulated in different cancers. This study was designed to explore the clinical significance and prognosis role of LINC00152.•The expression level of LINC00152 was positively correlated with tumor size, TNM stage and lymph node metastasis.•Elevated LINC00152 could predict unfavorable overall survival and poor disease-free survival in cancer patients.•This meta-analysis demonstrated that LINC00152 was correlated with advanced clinicopathological features and poor prognosis as a novel predictive biomarker in various cancers.</description><subject>Cancer</subject><subject>LINC00152</subject><subject>lncRNA</subject><subject>Meta-analysis</subject><subject>Prognosis</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kctuFDEQRS0EIkPgA9ggL9n0ULb7CatoxCPSKEhRWFtuu0w86nYPdveg-Qm-mRomZBnpSn7UrWP5FmNvBawFiPrDbm2tWUsQ7RoUqXzGVqJtVKHKTj5nKwDoirZrxQV7lfOOjiXU4iW7kF0tmlqWK_ZnO8WfPE7RTi7Q7vbmim-vbzYAopLcZG6oeMCB7xO6YOcp8cnz4Tju76ngkI84m0wKZI2O5yUdwsEMPER-v4wmcmuixfSRQPmYZxzNHCxPeAj4-1_HCVCYaIYjMV6zF94MGd88rJfsx5fPd5tvxfb71-vN1bawqlJzofq6d70FbDqr0FaGcqiqtoLK-aqmu8Zb25cdoICuBN-Y3niPbVkL78CiumTvz9x9mn4tmGc9hmxxGEzEaclagpRCdiSyirPVpinnhF7vUxhNOmoB-jQGvdP0vD6NQYMildTz7gG_9CO6x47_uZPh09mA9EmKIulsA1JQLiS0s3ZTeAL_F7D6mcA</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Zhang, Jiaming</creator><creator>Yin, Minuo</creator><creator>Huang, Junming</creator><creator>Lv, Zhengtao</creator><creator>Liang, Shuang</creator><creator>Miao, Xiaoao</creator><creator>Huang, Fang</creator><creator>Zhao, Yingchao</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8520-566X</orcidid></search><sort><creationdate>20180801</creationdate><title>Long noncoding RNA LINC00152 as a novel predictor of lymph node metastasis and survival in human cancer: a systematic review and meta-analysis</title><author>Zhang, Jiaming ; Yin, Minuo ; Huang, Junming ; Lv, Zhengtao ; Liang, Shuang ; Miao, Xiaoao ; Huang, Fang ; Zhao, Yingchao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-3b6bdbc0e79c3ec5acca558505df569c37fccb490e10940f7abaffe8461fd0ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cancer</topic><topic>LINC00152</topic><topic>lncRNA</topic><topic>Meta-analysis</topic><topic>Prognosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Jiaming</creatorcontrib><creatorcontrib>Yin, Minuo</creatorcontrib><creatorcontrib>Huang, Junming</creatorcontrib><creatorcontrib>Lv, Zhengtao</creatorcontrib><creatorcontrib>Liang, Shuang</creatorcontrib><creatorcontrib>Miao, Xiaoao</creatorcontrib><creatorcontrib>Huang, Fang</creatorcontrib><creatorcontrib>Zhao, Yingchao</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Jiaming</au><au>Yin, Minuo</au><au>Huang, Junming</au><au>Lv, Zhengtao</au><au>Liang, Shuang</au><au>Miao, Xiaoao</au><au>Huang, Fang</au><au>Zhao, Yingchao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long noncoding RNA LINC00152 as a novel predictor of lymph node metastasis and survival in human cancer: a systematic review and meta-analysis</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>483</volume><spage>25</spage><epage>32</epage><pages>25-32</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>LINC00152, a novel long noncoding RNA (lncRNA), was identified as an oncogene involved various cancers. This study was designed to explore the clinical significance and prognosis role of LINC00152.
Eligible studies were recruited by a systematic search in PubMed, Web of Science, and Embase up to August 23, 2017. Odds ratios (ORs), hazard ratios (HRs) and 95% confidence interval (95% CI) were pooled using Review Manager 5.3 and STATA 12.0.
A total of 10 studies with 913 patients were included to evaluate the association between LINC00152 expression and clinicopathological factors, overall survival (OS) and disease-free survivals (DFS). The results indicated that the expression level of LINC00152 was positively correlated with tumor size (OR = 5.19, 95% CI: 2.33–11.52, p < .0001), TNM stage (OR = 3.12, 95% CI: 1.77–5.51, p < .0001) and lymph node metastasis (OR = 3.41, 95% CI: 2.13–5.48, p < .00001). Moreover, elevated LINC00152 could predict unfavorable OS with pooled HR of 1.66 (95% CI: 1.29–2.13, p < .0001) and poor DFS (HR = 2.13, 95% CI: 1.39–3.25, p = .0005) in cancer patients.
LINC00152 was correlated with advanced clinicopathological features and poor prognosis as a novel predictive biomarker in various cancers.
•It has been reported that LINC00152 was dysregulated in different cancers. This study was designed to explore the clinical significance and prognosis role of LINC00152.•The expression level of LINC00152 was positively correlated with tumor size, TNM stage and lymph node metastasis.•Elevated LINC00152 could predict unfavorable overall survival and poor disease-free survival in cancer patients.•This meta-analysis demonstrated that LINC00152 was correlated with advanced clinicopathological features and poor prognosis as a novel predictive biomarker in various cancers.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>29617624</pmid><doi>10.1016/j.cca.2018.03.034</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8520-566X</orcidid></addata></record> |
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| subjects | Cancer LINC00152 lncRNA Meta-analysis Prognosis |
| title | Long noncoding RNA LINC00152 as a novel predictor of lymph node metastasis and survival in human cancer: a systematic review and meta-analysis |
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