Influence of a Single Point Mutation in the Constant Domain of the Bence-Jones Protein BIF on Its Aggregation Properties

Multiple myeloma nephropathy occurs due to the aggregate formation by monoclonal immunoglobulin light chains (Bence-Jones proteins) in kidneys of patients with multiple myeloma. The mechanism of amyloid deposit formation is still unclear. Earlier, the key role in the fibril formation has been assign...

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Veröffentlicht in:	Biochemistry (Moscow) 2018-02, Vol.83 (2), p.107-118
Hauptverfasser:	Timchenko, M. A., Timchenko, A. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Allotypes Amyloid Amyloid beta-protein Amyloidogenesis Atomic force microscopy Bence Jones Protein - chemistry Bence Jones Protein - genetics Bence Jones Protein - metabolism Bence-Jones proteins Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Care and treatment Development and progression Distal tubules Dithiothreitol Escherichia coli - metabolism Fibrils Gene mutation Genetic aspects Glomerulus Health aspects Humans Hydrogen-Ion Concentration Immunoglobulins Kidneys Life Sciences Light chains Microbiology Microscopy, Atomic Force Multiple myeloma Mutagenesis, Site-Directed Mutation Nephropathy pH effects Plasmids - genetics Plasmids - metabolism Point mutation Pressure Protein Aggregates - genetics Protein Refolding Protein transport Proteins Proximal tubules Recombinant Proteins - biosynthesis Recombinant Proteins - chemistry Recombinant Proteins - isolation & purification Renal tubules Scattering, Small Angle Substitutes Time Factors X-Ray Diffraction
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