The protective function of noncoding DNA in genome defense of eukaryotic male germ cells

Peripheral and abundant noncoding DNA has been hypothesized to protect the genome and the central protein-coding sequences against DNA damage in somatic genome. In the cytosol, invading exogenous nucleic acids may first be deactivated by small RNAs encoded by noncoding DNA via mechanisms similar to...

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Veröffentlicht in:	Epigenomics 2018-04, Vol.10 (4), p.499-517
Hauptverfasser:	Qiu, Guo-Hua, Huang, Cuiqin, Zheng, Xintian, Yang, Xiaoyan
Format:	Artikel
Sprache:	eng
Schlagworte:	bodyguard protection Bone marrow Cell cycle CRISPR CRISPR-like Cytoplasm Cytosol Deactivation Deoxyribonucleic acid DNA DNA damage Epigenetics Gene sequencing genome defense Genomes Germ cells Heterochromatin Lymphocytes Males Mutation noncoding DNA Nucleic acids Nucleotide sequence Organisms Proteins Sperm Stem cells
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