The protective function of noncoding DNA in genome defense of eukaryotic male germ cells
Peripheral and abundant noncoding DNA has been hypothesized to protect the genome and the central protein-coding sequences against DNA damage in somatic genome. In the cytosol, invading exogenous nucleic acids may first be deactivated by small RNAs encoded by noncoding DNA via mechanisms similar to...
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| Veröffentlicht in: | Epigenomics 2018-04, Vol.10 (4), p.499-517 |
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| creator | Qiu, Guo-Hua Huang, Cuiqin Zheng, Xintian Yang, Xiaoyan |
| description | Peripheral and abundant noncoding DNA has been hypothesized to protect the genome and the central protein-coding sequences against DNA damage in somatic genome. In the cytosol, invading exogenous nucleic acids may first be deactivated by small RNAs encoded by noncoding DNA via mechanisms similar to the prokaryotic CRISPR-Cas system. In the nucleus, the radicals generated by radiation in the cytosol, radiation energy and invading exogenous nucleic acids are absorbed, blocked and/or reduced by peripheral heterochromatin, and damaged DNA in heterochromatin is removed and excluded from the nucleus to the cytoplasm through nuclear pore complexes. To further strengthen the hypothesis, this review summarizes the experimental evidence supporting the protective function of noncoding DNA in the genome of male germ cells. Based on these data, this review provides evidence supporting the protective role of noncoding DNA in the genome defense of sperm genome through similar mechanisms to those of the somatic genome. |
| doi_str_mv | 10.2217/epi-2017-0103 |
| format | Article |
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In the cytosol, invading exogenous nucleic acids may first be deactivated by small RNAs encoded by noncoding DNA via mechanisms similar to the prokaryotic CRISPR-Cas system. In the nucleus, the radicals generated by radiation in the cytosol, radiation energy and invading exogenous nucleic acids are absorbed, blocked and/or reduced by peripheral heterochromatin, and damaged DNA in heterochromatin is removed and excluded from the nucleus to the cytoplasm through nuclear pore complexes. To further strengthen the hypothesis, this review summarizes the experimental evidence supporting the protective function of noncoding DNA in the genome of male germ cells. 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In the cytosol, invading exogenous nucleic acids may first be deactivated by small RNAs encoded by noncoding DNA via mechanisms similar to the prokaryotic CRISPR-Cas system. In the nucleus, the radicals generated by radiation in the cytosol, radiation energy and invading exogenous nucleic acids are absorbed, blocked and/or reduced by peripheral heterochromatin, and damaged DNA in heterochromatin is removed and excluded from the nucleus to the cytoplasm through nuclear pore complexes. To further strengthen the hypothesis, this review summarizes the experimental evidence supporting the protective function of noncoding DNA in the genome of male germ cells. Based on these data, this review provides evidence supporting the protective role of noncoding DNA in the genome defense of sperm genome through similar mechanisms to those of the somatic genome.</description><subject>bodyguard protection</subject><subject>Bone marrow</subject><subject>Cell cycle</subject><subject>CRISPR</subject><subject>CRISPR-like</subject><subject>Cytoplasm</subject><subject>Cytosol</subject><subject>Deactivation</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>Epigenetics</subject><subject>Gene sequencing</subject><subject>genome defense</subject><subject>Genomes</subject><subject>Germ cells</subject><subject>Heterochromatin</subject><subject>Lymphocytes</subject><subject>Males</subject><subject>Mutation</subject><subject>noncoding DNA</subject><subject>Nucleic acids</subject><subject>Nucleotide sequence</subject><subject>Organisms</subject><subject>Proteins</subject><subject>Sperm</subject><subject>Stem cells</subject><issn>1750-1911</issn><issn>1750-192X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kE1LxDAQhoMoKrpHrxLw4qWaj23THJf1E0QvCnsLbTpZo9tkbVrBf--U1T0I5jIz8ORl5iHkhLMLIbi6hLXPBOMqY5zJHXLIVc4yrsVid9tzfkAmKb0xfFKUuuD75EBgKXI9PSSL51eg6y72YHv_CdQNAZsYaHQ0xGBj48OSXj3OqA90CSG2QBtwEBKMCAzvVfcVe29pW60Aia6lFlardEz2XLVKMPmpR-Tl5vp5fpc9PN3ez2cPmZWK95mUupkKPS2tU41TSvKyyLl1IBsn67zASdlaV3UDpZUVNDUUFct1rquyZFMhj8j5JheP-Bgg9ab1adygChCHZARDURI9FIie_UHf4tAF3M6gzSIXpRIaqWxD2S6m1IEz6863eKXhbOSUQetmtG5G68if_qQOdQvNlv51jIDeAG7ohw6S9RAsmM2EP7z1Af4J_wYATY_v</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Qiu, Guo-Hua</creator><creator>Huang, Cuiqin</creator><creator>Zheng, Xintian</creator><creator>Yang, Xiaoyan</creator><general>Future Medicine Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180401</creationdate><title>The protective function of noncoding DNA in genome defense of eukaryotic male germ cells</title><author>Qiu, Guo-Hua ; Huang, Cuiqin ; Zheng, Xintian ; Yang, Xiaoyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-339d42948cf7df77318651cfe3df3b568657cb9abde8c3aedbe6a05959a880423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>bodyguard protection</topic><topic>Bone marrow</topic><topic>Cell cycle</topic><topic>CRISPR</topic><topic>CRISPR-like</topic><topic>Cytoplasm</topic><topic>Cytosol</topic><topic>Deactivation</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA damage</topic><topic>Epigenetics</topic><topic>Gene sequencing</topic><topic>genome defense</topic><topic>Genomes</topic><topic>Germ cells</topic><topic>Heterochromatin</topic><topic>Lymphocytes</topic><topic>Males</topic><topic>Mutation</topic><topic>noncoding DNA</topic><topic>Nucleic acids</topic><topic>Nucleotide sequence</topic><topic>Organisms</topic><topic>Proteins</topic><topic>Sperm</topic><topic>Stem cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qiu, Guo-Hua</creatorcontrib><creatorcontrib>Huang, Cuiqin</creatorcontrib><creatorcontrib>Zheng, Xintian</creatorcontrib><creatorcontrib>Yang, Xiaoyan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Epigenomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qiu, Guo-Hua</au><au>Huang, Cuiqin</au><au>Zheng, Xintian</au><au>Yang, Xiaoyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The protective function of noncoding DNA in genome defense of eukaryotic male germ cells</atitle><jtitle>Epigenomics</jtitle><addtitle>Epigenomics</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>10</volume><issue>4</issue><spage>499</spage><epage>517</epage><pages>499-517</pages><issn>1750-1911</issn><eissn>1750-192X</eissn><abstract>Peripheral and abundant noncoding DNA has been hypothesized to protect the genome and the central protein-coding sequences against DNA damage in somatic genome. In the cytosol, invading exogenous nucleic acids may first be deactivated by small RNAs encoded by noncoding DNA via mechanisms similar to the prokaryotic CRISPR-Cas system. In the nucleus, the radicals generated by radiation in the cytosol, radiation energy and invading exogenous nucleic acids are absorbed, blocked and/or reduced by peripheral heterochromatin, and damaged DNA in heterochromatin is removed and excluded from the nucleus to the cytoplasm through nuclear pore complexes. To further strengthen the hypothesis, this review summarizes the experimental evidence supporting the protective function of noncoding DNA in the genome of male germ cells. Based on these data, this review provides evidence supporting the protective role of noncoding DNA in the genome defense of sperm genome through similar mechanisms to those of the somatic genome.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>29616594</pmid><doi>10.2217/epi-2017-0103</doi><tpages>19</tpages></addata></record> |
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| subjects | bodyguard protection Bone marrow Cell cycle CRISPR CRISPR-like Cytoplasm Cytosol Deactivation Deoxyribonucleic acid DNA DNA damage Epigenetics Gene sequencing genome defense Genomes Germ cells Heterochromatin Lymphocytes Males Mutation noncoding DNA Nucleic acids Nucleotide sequence Organisms Proteins Sperm Stem cells |
| title | The protective function of noncoding DNA in genome defense of eukaryotic male germ cells |
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