Dysfunction of Mesenchymal Stem Cells Isolated from Metabolic Syndrome and Type 2 Diabetic Patients as Result of Oxidative Stress and Autophagy may Limit Their Potential Therapeutic Use

Mesenchymal stem cells (MSC) have become a promising tool for therapeutic intervention. Their unique features, including self-renewal, multipotency and immunomodulatory properties draw the worldwide attention of researchers and physicians with respect to their application in disease treatment. Howev...

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Veröffentlicht in:	Stem cell reviews 2018-06, Vol.14 (3), p.337-345
Hauptverfasser:	Kornicka, Katarzyna, Houston, Jenny, Marycz, Krzysztof
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Aging - physiology Animals Apoptosis Autografts Autophagy Autophagy - genetics Autophagy - physiology Biomedical and Life Sciences Biomedical Engineering and Bioengineering Cell Biology Cell self-renewal Data processing Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Humans Immunomodulation Life Sciences Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mesenchymal Stem Cells - pathology Mesenchyme Metabolic syndrome Metabolic Syndrome - metabolism Metabolic Syndrome - pathology Mitochondria Oxidative stress Oxidative Stress - genetics Oxidative Stress - physiology Phagocytosis Regenerative Medicine Regenerative Medicine/Tissue Engineering Signal Transduction - genetics Signal Transduction - physiology Stem Cells
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