Safranal carried by nanostructured lipid vehicles inhibits generalized epilepsy in mice
Safranal, a main component of Crocus sativus, is suggested to have neuroprotective effects. The aim of this study was to investigate the effect of safranal and nanostructured lipid vehicle (NLV) carried safranal in acute and chronic experimental mice models of epilepsy. In PILO acute seizure model,...
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Veröffentlicht in: | Pharmazie 2018-04, Vol.73 (4), p.207-212 |
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creator | Bo-Qiang, Liu Si-Tong, Zhang Zu-Yuan, Lin Wan-Yun, Nie Bin, Chen Yuan, Lu Xuyun, Li Liangen, Mao You-Chao, Chen Xin-Zhen, Yin Zhong, Chen Xiao-Ying, Ying Wei-Wei, Hu |
description | Safranal, a main component of Crocus sativus, is suggested to have neuroprotective effects. The aim of this study was to investigate the effect of safranal and nanostructured lipid vehicle (NLV) carried safranal in acute and chronic experimental mice models of epilepsy. In PILO
acute seizure model, safranal dose-dependently extended latency to generalized seizure, decreased the highest seizure stages and the number of generalized seizures. Moreover, NLV carried safranal further enhanced the anti-seizure effect, which is comparable to the action of sodium valproate.
Meanwhile, NLV carried safranal reduced and delayed the electroencephalogram spectra power after pilocarpine injection. In histological aspect, safranal dose-dependently reduced the loss of neurons induced by seizure and NLV system further improved this protection at the same dose. In MES
acute model, safranal markedly increased the electroconvulsive threshold, where NLV further improved its effect. In PTZ chronic seizure model, NLV carried safranal significantly delayed the kindling rate of progress and the time it took to reach generalized seizures as compared to NLV control
group. In conclusion, this study indicates that safranal inhibits generalized seizure in acute and chronic epilepsy models in mice and NLV can enhance this effect. So, NLV carried safranal may have potential value in treatment of generalized epilepsy. |
doi_str_mv | 10.1691/ph.2018.7310 |
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acute seizure model, safranal dose-dependently extended latency to generalized seizure, decreased the highest seizure stages and the number of generalized seizures. Moreover, NLV carried safranal further enhanced the anti-seizure effect, which is comparable to the action of sodium valproate.
Meanwhile, NLV carried safranal reduced and delayed the electroencephalogram spectra power after pilocarpine injection. In histological aspect, safranal dose-dependently reduced the loss of neurons induced by seizure and NLV system further improved this protection at the same dose. In MES
acute model, safranal markedly increased the electroconvulsive threshold, where NLV further improved its effect. In PTZ chronic seizure model, NLV carried safranal significantly delayed the kindling rate of progress and the time it took to reach generalized seizures as compared to NLV control
group. In conclusion, this study indicates that safranal inhibits generalized seizure in acute and chronic epilepsy models in mice and NLV can enhance this effect. So, NLV carried safranal may have potential value in treatment of generalized epilepsy.</description><identifier>ISSN: 0031-7144</identifier><identifier>DOI: 10.1691/ph.2018.7310</identifier><identifier>PMID: 29609687</identifier><language>eng</language><publisher>Germany: Govi-Verlag</publisher><subject>Animals ; Anticonvulsants - administration & dosage ; Anticonvulsants - therapeutic use ; Convulsants ; Cyclohexenes - administration & dosage ; Cyclohexenes - therapeutic use ; Dose-Response Relationship, Drug ; Drug Compounding ; Electroencephalography ; Electroshock ; Epilepsy, Generalized - chemically induced ; Epilepsy, Generalized - drug therapy ; Kindling, Neurologic - drug effects ; Lipids - chemistry ; Male ; Mice ; Particle Size ; Pharmaceutical Vehicles ; Pilocarpine ; Terpenes - administration & dosage ; Terpenes - therapeutic use</subject><ispartof>Pharmazie, 2018-04, Vol.73 (4), p.207-212</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-afc6547dee36ff86ad54844ef57a0c61f65405ed708794eaf4f10abdee1656073</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29609687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bo-Qiang, Liu</creatorcontrib><creatorcontrib>Si-Tong, Zhang</creatorcontrib><creatorcontrib>Zu-Yuan, Lin</creatorcontrib><creatorcontrib>Wan-Yun, Nie</creatorcontrib><creatorcontrib>Bin, Chen</creatorcontrib><creatorcontrib>Yuan, Lu</creatorcontrib><creatorcontrib>Xuyun, Li</creatorcontrib><creatorcontrib>Liangen, Mao</creatorcontrib><creatorcontrib>You-Chao, Chen</creatorcontrib><creatorcontrib>Xin-Zhen, Yin</creatorcontrib><creatorcontrib>Zhong, Chen</creatorcontrib><creatorcontrib>Xiao-Ying, Ying</creatorcontrib><creatorcontrib>Wei-Wei, Hu</creatorcontrib><title>Safranal carried by nanostructured lipid vehicles inhibits generalized epilepsy in mice</title><title>Pharmazie</title><addtitle>Pharmazie</addtitle><addtitle>Pharmazie</addtitle><description>Safranal, a main component of Crocus sativus, is suggested to have neuroprotective effects. The aim of this study was to investigate the effect of safranal and nanostructured lipid vehicle (NLV) carried safranal in acute and chronic experimental mice models of epilepsy. In PILO
acute seizure model, safranal dose-dependently extended latency to generalized seizure, decreased the highest seizure stages and the number of generalized seizures. Moreover, NLV carried safranal further enhanced the anti-seizure effect, which is comparable to the action of sodium valproate.
Meanwhile, NLV carried safranal reduced and delayed the electroencephalogram spectra power after pilocarpine injection. In histological aspect, safranal dose-dependently reduced the loss of neurons induced by seizure and NLV system further improved this protection at the same dose. In MES
acute model, safranal markedly increased the electroconvulsive threshold, where NLV further improved its effect. In PTZ chronic seizure model, NLV carried safranal significantly delayed the kindling rate of progress and the time it took to reach generalized seizures as compared to NLV control
group. In conclusion, this study indicates that safranal inhibits generalized seizure in acute and chronic epilepsy models in mice and NLV can enhance this effect. So, NLV carried safranal may have potential value in treatment of generalized epilepsy.</description><subject>Animals</subject><subject>Anticonvulsants - administration & dosage</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Convulsants</subject><subject>Cyclohexenes - administration & dosage</subject><subject>Cyclohexenes - therapeutic use</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Compounding</subject><subject>Electroencephalography</subject><subject>Electroshock</subject><subject>Epilepsy, Generalized - chemically induced</subject><subject>Epilepsy, Generalized - drug therapy</subject><subject>Kindling, Neurologic - drug effects</subject><subject>Lipids - chemistry</subject><subject>Male</subject><subject>Mice</subject><subject>Particle Size</subject><subject>Pharmaceutical Vehicles</subject><subject>Pilocarpine</subject><subject>Terpenes - administration & dosage</subject><subject>Terpenes - therapeutic use</subject><issn>0031-7144</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kb1vFDEQxV0EkRDoUqMtae7ir7V3SxQIIEWkCIjSmvOO7xx5P7C9J9399Xhzl5JpZuT307P9hpAbRtdMtex22q05Zc1aC0YvyBWlgq00k_KSvEvpmVKuuGrekkveKtqqRl-RP0_gIgwQKgsxeuyqzaEaYBhTjrPNcywnwU--q_a48zZgqvyw8xufU7XFASMEfywMTj7glA5FrXpv8T154yAk_HDu1-T3_ddfd99XD4_fftx9flhZ0ai8AmdVLXWHKJRzjYKulo2U6GoN1Crmikpr7DRtdCsRnHSMwqbwTNWKanFNPp18pzj-nTFl0_tkMQQYcJyT4ZQzwVrO6oJ-PKPzpsfOTNH3EA_mNYwCfDkBfihfy2CexzmWaJLZjntvph3EHo5mSdjQl9LiPFBpIOZlWO75-R8bb09Oy16WtZi9FoN8eSNtmDCMcW46dDCHbDJEsz2aVIt_KH2QEg</recordid><startdate>20180402</startdate><enddate>20180402</enddate><creator>Bo-Qiang, Liu</creator><creator>Si-Tong, Zhang</creator><creator>Zu-Yuan, Lin</creator><creator>Wan-Yun, Nie</creator><creator>Bin, Chen</creator><creator>Yuan, Lu</creator><creator>Xuyun, Li</creator><creator>Liangen, Mao</creator><creator>You-Chao, Chen</creator><creator>Xin-Zhen, Yin</creator><creator>Zhong, Chen</creator><creator>Xiao-Ying, Ying</creator><creator>Wei-Wei, Hu</creator><general>Govi-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20180402</creationdate><title>Safranal carried by nanostructured lipid vehicles inhibits generalized epilepsy in mice</title><author>Bo-Qiang, Liu ; Si-Tong, Zhang ; Zu-Yuan, Lin ; Wan-Yun, Nie ; Bin, Chen ; Yuan, Lu ; Xuyun, Li ; Liangen, Mao ; You-Chao, Chen ; Xin-Zhen, Yin ; Zhong, Chen ; Xiao-Ying, Ying ; Wei-Wei, Hu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-afc6547dee36ff86ad54844ef57a0c61f65405ed708794eaf4f10abdee1656073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Anticonvulsants - administration & dosage</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Convulsants</topic><topic>Cyclohexenes - administration & dosage</topic><topic>Cyclohexenes - therapeutic use</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Compounding</topic><topic>Electroencephalography</topic><topic>Electroshock</topic><topic>Epilepsy, Generalized - chemically induced</topic><topic>Epilepsy, Generalized - drug therapy</topic><topic>Kindling, Neurologic - drug effects</topic><topic>Lipids - chemistry</topic><topic>Male</topic><topic>Mice</topic><topic>Particle Size</topic><topic>Pharmaceutical Vehicles</topic><topic>Pilocarpine</topic><topic>Terpenes - administration & dosage</topic><topic>Terpenes - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bo-Qiang, Liu</creatorcontrib><creatorcontrib>Si-Tong, Zhang</creatorcontrib><creatorcontrib>Zu-Yuan, Lin</creatorcontrib><creatorcontrib>Wan-Yun, Nie</creatorcontrib><creatorcontrib>Bin, Chen</creatorcontrib><creatorcontrib>Yuan, Lu</creatorcontrib><creatorcontrib>Xuyun, Li</creatorcontrib><creatorcontrib>Liangen, Mao</creatorcontrib><creatorcontrib>You-Chao, Chen</creatorcontrib><creatorcontrib>Xin-Zhen, Yin</creatorcontrib><creatorcontrib>Zhong, Chen</creatorcontrib><creatorcontrib>Xiao-Ying, Ying</creatorcontrib><creatorcontrib>Wei-Wei, Hu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmazie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bo-Qiang, Liu</au><au>Si-Tong, Zhang</au><au>Zu-Yuan, Lin</au><au>Wan-Yun, Nie</au><au>Bin, Chen</au><au>Yuan, Lu</au><au>Xuyun, Li</au><au>Liangen, Mao</au><au>You-Chao, Chen</au><au>Xin-Zhen, Yin</au><au>Zhong, Chen</au><au>Xiao-Ying, Ying</au><au>Wei-Wei, Hu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safranal carried by nanostructured lipid vehicles inhibits generalized epilepsy in mice</atitle><jtitle>Pharmazie</jtitle><stitle>Pharmazie</stitle><addtitle>Pharmazie</addtitle><date>2018-04-02</date><risdate>2018</risdate><volume>73</volume><issue>4</issue><spage>207</spage><epage>212</epage><pages>207-212</pages><issn>0031-7144</issn><abstract>Safranal, a main component of Crocus sativus, is suggested to have neuroprotective effects. The aim of this study was to investigate the effect of safranal and nanostructured lipid vehicle (NLV) carried safranal in acute and chronic experimental mice models of epilepsy. In PILO
acute seizure model, safranal dose-dependently extended latency to generalized seizure, decreased the highest seizure stages and the number of generalized seizures. Moreover, NLV carried safranal further enhanced the anti-seizure effect, which is comparable to the action of sodium valproate.
Meanwhile, NLV carried safranal reduced and delayed the electroencephalogram spectra power after pilocarpine injection. In histological aspect, safranal dose-dependently reduced the loss of neurons induced by seizure and NLV system further improved this protection at the same dose. In MES
acute model, safranal markedly increased the electroconvulsive threshold, where NLV further improved its effect. In PTZ chronic seizure model, NLV carried safranal significantly delayed the kindling rate of progress and the time it took to reach generalized seizures as compared to NLV control
group. In conclusion, this study indicates that safranal inhibits generalized seizure in acute and chronic epilepsy models in mice and NLV can enhance this effect. So, NLV carried safranal may have potential value in treatment of generalized epilepsy.</abstract><cop>Germany</cop><pub>Govi-Verlag</pub><pmid>29609687</pmid><doi>10.1691/ph.2018.7310</doi><tpages>6</tpages></addata></record> |
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subjects | Animals Anticonvulsants - administration & dosage Anticonvulsants - therapeutic use Convulsants Cyclohexenes - administration & dosage Cyclohexenes - therapeutic use Dose-Response Relationship, Drug Drug Compounding Electroencephalography Electroshock Epilepsy, Generalized - chemically induced Epilepsy, Generalized - drug therapy Kindling, Neurologic - drug effects Lipids - chemistry Male Mice Particle Size Pharmaceutical Vehicles Pilocarpine Terpenes - administration & dosage Terpenes - therapeutic use |
title | Safranal carried by nanostructured lipid vehicles inhibits generalized epilepsy in mice |
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