Safranal carried by nanostructured lipid vehicles inhibits generalized epilepsy in mice

Safranal, a main component of Crocus sativus, is suggested to have neuroprotective effects. The aim of this study was to investigate the effect of safranal and nanostructured lipid vehicle (NLV) carried safranal in acute and chronic experimental mice models of epilepsy. In PILO acute seizure model,...

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Veröffentlicht in:Pharmazie 2018-04, Vol.73 (4), p.207-212
Hauptverfasser: Bo-Qiang, Liu, Si-Tong, Zhang, Zu-Yuan, Lin, Wan-Yun, Nie, Bin, Chen, Yuan, Lu, Xuyun, Li, Liangen, Mao, You-Chao, Chen, Xin-Zhen, Yin, Zhong, Chen, Xiao-Ying, Ying, Wei-Wei, Hu
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container_issue 4
container_start_page 207
container_title Pharmazie
container_volume 73
creator Bo-Qiang, Liu
Si-Tong, Zhang
Zu-Yuan, Lin
Wan-Yun, Nie
Bin, Chen
Yuan, Lu
Xuyun, Li
Liangen, Mao
You-Chao, Chen
Xin-Zhen, Yin
Zhong, Chen
Xiao-Ying, Ying
Wei-Wei, Hu
description Safranal, a main component of Crocus sativus, is suggested to have neuroprotective effects. The aim of this study was to investigate the effect of safranal and nanostructured lipid vehicle (NLV) carried safranal in acute and chronic experimental mice models of epilepsy. In PILO acute seizure model, safranal dose-dependently extended latency to generalized seizure, decreased the highest seizure stages and the number of generalized seizures. Moreover, NLV carried safranal further enhanced the anti-seizure effect, which is comparable to the action of sodium valproate. Meanwhile, NLV carried safranal reduced and delayed the electroencephalogram spectra power after pilocarpine injection. In histological aspect, safranal dose-dependently reduced the loss of neurons induced by seizure and NLV system further improved this protection at the same dose. In MES acute model, safranal markedly increased the electroconvulsive threshold, where NLV further improved its effect. In PTZ chronic seizure model, NLV carried safranal significantly delayed the kindling rate of progress and the time it took to reach generalized seizures as compared to NLV control group. In conclusion, this study indicates that safranal inhibits generalized seizure in acute and chronic epilepsy models in mice and NLV can enhance this effect. So, NLV carried safranal may have potential value in treatment of generalized epilepsy.
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The aim of this study was to investigate the effect of safranal and nanostructured lipid vehicle (NLV) carried safranal in acute and chronic experimental mice models of epilepsy. In PILO acute seizure model, safranal dose-dependently extended latency to generalized seizure, decreased the highest seizure stages and the number of generalized seizures. Moreover, NLV carried safranal further enhanced the anti-seizure effect, which is comparable to the action of sodium valproate. Meanwhile, NLV carried safranal reduced and delayed the electroencephalogram spectra power after pilocarpine injection. In histological aspect, safranal dose-dependently reduced the loss of neurons induced by seizure and NLV system further improved this protection at the same dose. In MES acute model, safranal markedly increased the electroconvulsive threshold, where NLV further improved its effect. In PTZ chronic seizure model, NLV carried safranal significantly delayed the kindling rate of progress and the time it took to reach generalized seizures as compared to NLV control group. In conclusion, this study indicates that safranal inhibits generalized seizure in acute and chronic epilepsy models in mice and NLV can enhance this effect. 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In PTZ chronic seizure model, NLV carried safranal significantly delayed the kindling rate of progress and the time it took to reach generalized seizures as compared to NLV control group. In conclusion, this study indicates that safranal inhibits generalized seizure in acute and chronic epilepsy models in mice and NLV can enhance this effect. So, NLV carried safranal may have potential value in treatment of generalized epilepsy.</abstract><cop>Germany</cop><pub>Govi-Verlag</pub><pmid>29609687</pmid><doi>10.1691/ph.2018.7310</doi><tpages>6</tpages></addata></record>
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subjects Animals
Anticonvulsants - administration & dosage
Anticonvulsants - therapeutic use
Convulsants
Cyclohexenes - administration & dosage
Cyclohexenes - therapeutic use
Dose-Response Relationship, Drug
Drug Compounding
Electroencephalography
Electroshock
Epilepsy, Generalized - chemically induced
Epilepsy, Generalized - drug therapy
Kindling, Neurologic - drug effects
Lipids - chemistry
Male
Mice
Particle Size
Pharmaceutical Vehicles
Pilocarpine
Terpenes - administration & dosage
Terpenes - therapeutic use
title Safranal carried by nanostructured lipid vehicles inhibits generalized epilepsy in mice
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