Prescription drugs among pregnant women in Lome, Togo, West Africa
Objective To assess the trends in prescription drugs and the potential repercussions to newborns among pregnant women who attended prenatal consultations and gave birth in the Department of Gynaecology of Tokoin’s University Hospital, Lome (Togo). Methods A retrospective study of the registers of pr...
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| Veröffentlicht in: | European journal of clinical pharmacology 2009-08, Vol.65 (8), p.831-838 |
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| container_title | European journal of clinical pharmacology |
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| creator | Potchoo, Yao Redah, Datouda Gneni, Malick A. Guissou, Innocent P. |
| description | Objective
To assess the trends in prescription drugs and the potential repercussions to newborns among pregnant women who attended prenatal consultations and gave birth in the Department of Gynaecology of Tokoin’s University Hospital, Lome (Togo).
Methods
A retrospective study of the registers of prenatal visits and deliveries of the eligible population was performed.
Results
In total, 184 different drugs were prescribed to 627 pregnant women attending prenatal consultations. The profile of pharmacotherapeutic groups prescribed was: anti-anaemics (33.33%), antimalarial drugs (24.75%), vitamins ± mineral salts, amino acids and appetite stimulants (14.96%) and antispasmodics and anti-emetics (7.22%). The median proportion of prescriptions for each pharmacotherapeutic group increased significantly from the first to third trimester (9.72, 25.17 and 64.00 respectively;
P
|
| doi_str_mv | 10.1007/s00228-009-0644-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_20211879</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1802740391</sourcerecordid><originalsourceid>FETCH-LOGICAL-c430t-5208e63fbdff4b3e8017009786617db75e75d1cfefb04f3c6476580885f7cfc63</originalsourceid><addsrcrecordid>eNp1kEtrHDEQhIVxsDdOfoAvQRiSkyfu1mOkOdomL1iIDw45Co1GGsbsSBtph5B_Hy272BDIqRv6q-qiCLlE-IgA6qYAMKYbgK6BVohGnpAVCs4aBIGnZAXAsWk7BefkdSlPACg74GfkHDvOlWJ6Re4esi8uT9vdlCId8jIWaucUR7rNfow27ujvNPtIp0jXdbmmj2lM1_SnLzt6G_Lk7BvyKthN8W-P84L8-Pzp8f5rs_7-5dv97bpxgsOukQy0b3nohxBEz70GVDW50m2LauiV9EoO6IIPPYjAXStUKzVoLYNywbX8gnw4-G5z-rXU_2aeivObjY0-LcUwYIhadRW8-gd8SkuONZthKITqhNy74QFyOZWSfTDbPM02_zEIZt-uObRrakazb9fIqnl3NF762Q8vimOdFXh_BGxxdhOyjW4qzxxDJRmHPccOXKmnOPr8kvD_3_8C6HqPjw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>214479456</pqid></control><display><type>article</type><title>Prescription drugs among pregnant women in Lome, Togo, West Africa</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Potchoo, Yao ; Redah, Datouda ; Gneni, Malick A. ; Guissou, Innocent P.</creator><creatorcontrib>Potchoo, Yao ; Redah, Datouda ; Gneni, Malick A. ; Guissou, Innocent P.</creatorcontrib><description>Objective
To assess the trends in prescription drugs and the potential repercussions to newborns among pregnant women who attended prenatal consultations and gave birth in the Department of Gynaecology of Tokoin’s University Hospital, Lome (Togo).
Methods
A retrospective study of the registers of prenatal visits and deliveries of the eligible population was performed.
Results
In total, 184 different drugs were prescribed to 627 pregnant women attending prenatal consultations. The profile of pharmacotherapeutic groups prescribed was: anti-anaemics (33.33%), antimalarial drugs (24.75%), vitamins ± mineral salts, amino acids and appetite stimulants (14.96%) and antispasmodics and anti-emetics (7.22%). The median proportion of prescriptions for each pharmacotherapeutic group increased significantly from the first to third trimester (9.72, 25.17 and 64.00 respectively;
P
< 0.05). The median number of drugs prescribed did not vary significantly (
P
= 0.051) with the age groups, parity (
P
= 0.068) or obstetrical–gynaecological history (
P
= 0.401); it did, however, increase significantly with the medical–surgical history (
P
< 0.05). There were complications associated with deliveries that had no obvious cause related to drug prescription, including four cases of minor defects, 28 stillborns, 65 cases of low birth weight and 27 hospitalised newborns for neonatal diseases. Some interventions were needed for safeguarding the health of the mother, the foetus and the newborn.
Conclusion
The trends in obtaining prescription drugs and the consumption of drugs by pregnant women can be assessed using multiple parameters. We limited our study to age groups, gestational age, parity and the medical history of the pregnant woman, profile of pharmacotherapeutic groups, median number of drugs prescribed and the potential risks of the drugs used. The results of our retrospective study were not alarming in terms of neonatal outcomes.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/s00228-009-0644-5</identifier><identifier>PMID: 19337728</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Analgesics - therapeutic use ; Anti-Anxiety Agents - therapeutic use ; Antiemetics - therapeutic use ; Antihypertensive Agents - therapeutic use ; Antimalarials - therapeutic use ; Antiparasitic Agents - therapeutic use ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Drug Prescriptions - statistics & numerical data ; Female ; Gestational Age ; Hematinics - therapeutic use ; Humans ; Medical sciences ; Pharmacoepidemiology and Prescription ; Pharmacology ; Pharmacology. Drug treatments ; Pharmacology/Toxicology ; Practice Patterns, Physicians' - statistics & numerical data ; Pregnancy ; Pregnancy Complications - drug therapy ; Pregnancy Complications - prevention & control ; Pregnancy Outcome ; Pregnancy Trimesters ; Prenatal care ; Prescription drugs ; Prescription Drugs - adverse effects ; Prescription Drugs - therapeutic use ; Retrospective Studies ; Risk factors ; Socioeconomic Factors ; Togo ; Young Adult</subject><ispartof>European journal of clinical pharmacology, 2009-08, Vol.65 (8), p.831-838</ispartof><rights>Springer-Verlag 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-5208e63fbdff4b3e8017009786617db75e75d1cfefb04f3c6476580885f7cfc63</citedby><cites>FETCH-LOGICAL-c430t-5208e63fbdff4b3e8017009786617db75e75d1cfefb04f3c6476580885f7cfc63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00228-009-0644-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00228-009-0644-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21752308$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19337728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Potchoo, Yao</creatorcontrib><creatorcontrib>Redah, Datouda</creatorcontrib><creatorcontrib>Gneni, Malick A.</creatorcontrib><creatorcontrib>Guissou, Innocent P.</creatorcontrib><title>Prescription drugs among pregnant women in Lome, Togo, West Africa</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><addtitle>Eur J Clin Pharmacol</addtitle><description>Objective
To assess the trends in prescription drugs and the potential repercussions to newborns among pregnant women who attended prenatal consultations and gave birth in the Department of Gynaecology of Tokoin’s University Hospital, Lome (Togo).
Methods
A retrospective study of the registers of prenatal visits and deliveries of the eligible population was performed.
Results
In total, 184 different drugs were prescribed to 627 pregnant women attending prenatal consultations. The profile of pharmacotherapeutic groups prescribed was: anti-anaemics (33.33%), antimalarial drugs (24.75%), vitamins ± mineral salts, amino acids and appetite stimulants (14.96%) and antispasmodics and anti-emetics (7.22%). The median proportion of prescriptions for each pharmacotherapeutic group increased significantly from the first to third trimester (9.72, 25.17 and 64.00 respectively;
P
< 0.05). The median number of drugs prescribed did not vary significantly (
P
= 0.051) with the age groups, parity (
P
= 0.068) or obstetrical–gynaecological history (
P
= 0.401); it did, however, increase significantly with the medical–surgical history (
P
< 0.05). There were complications associated with deliveries that had no obvious cause related to drug prescription, including four cases of minor defects, 28 stillborns, 65 cases of low birth weight and 27 hospitalised newborns for neonatal diseases. Some interventions were needed for safeguarding the health of the mother, the foetus and the newborn.
Conclusion
The trends in obtaining prescription drugs and the consumption of drugs by pregnant women can be assessed using multiple parameters. We limited our study to age groups, gestational age, parity and the medical history of the pregnant woman, profile of pharmacotherapeutic groups, median number of drugs prescribed and the potential risks of the drugs used. The results of our retrospective study were not alarming in terms of neonatal outcomes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analgesics - therapeutic use</subject><subject>Anti-Anxiety Agents - therapeutic use</subject><subject>Antiemetics - therapeutic use</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Antimalarials - therapeutic use</subject><subject>Antiparasitic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Drug Prescriptions - statistics & numerical data</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Hematinics - therapeutic use</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacoepidemiology and Prescription</subject><subject>Pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pharmacology/Toxicology</subject><subject>Practice Patterns, Physicians' - statistics & numerical data</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - drug therapy</subject><subject>Pregnancy Complications - prevention & control</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy Trimesters</subject><subject>Prenatal care</subject><subject>Prescription drugs</subject><subject>Prescription Drugs - adverse effects</subject><subject>Prescription Drugs - therapeutic use</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Socioeconomic Factors</subject><subject>Togo</subject><subject>Young Adult</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kEtrHDEQhIVxsDdOfoAvQRiSkyfu1mOkOdomL1iIDw45Co1GGsbsSBtph5B_Hy272BDIqRv6q-qiCLlE-IgA6qYAMKYbgK6BVohGnpAVCs4aBIGnZAXAsWk7BefkdSlPACg74GfkHDvOlWJ6Re4esi8uT9vdlCId8jIWaucUR7rNfow27ujvNPtIp0jXdbmmj2lM1_SnLzt6G_Lk7BvyKthN8W-P84L8-Pzp8f5rs_7-5dv97bpxgsOukQy0b3nohxBEz70GVDW50m2LauiV9EoO6IIPPYjAXStUKzVoLYNywbX8gnw4-G5z-rXU_2aeivObjY0-LcUwYIhadRW8-gd8SkuONZthKITqhNy74QFyOZWSfTDbPM02_zEIZt-uObRrakazb9fIqnl3NF762Q8vimOdFXh_BGxxdhOyjW4qzxxDJRmHPccOXKmnOPr8kvD_3_8C6HqPjw</recordid><startdate>20090801</startdate><enddate>20090801</enddate><creator>Potchoo, Yao</creator><creator>Redah, Datouda</creator><creator>Gneni, Malick A.</creator><creator>Guissou, Innocent P.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20090801</creationdate><title>Prescription drugs among pregnant women in Lome, Togo, West Africa</title><author>Potchoo, Yao ; Redah, Datouda ; Gneni, Malick A. ; Guissou, Innocent P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-5208e63fbdff4b3e8017009786617db75e75d1cfefb04f3c6476580885f7cfc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analgesics - therapeutic use</topic><topic>Anti-Anxiety Agents - therapeutic use</topic><topic>Antiemetics - therapeutic use</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Antimalarials - therapeutic use</topic><topic>Antiparasitic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Drug Prescriptions - statistics & numerical data</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Hematinics - therapeutic use</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacoepidemiology and Prescription</topic><topic>Pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pharmacology/Toxicology</topic><topic>Practice Patterns, Physicians' - statistics & numerical data</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - drug therapy</topic><topic>Pregnancy Complications - prevention & control</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy Trimesters</topic><topic>Prenatal care</topic><topic>Prescription drugs</topic><topic>Prescription Drugs - adverse effects</topic><topic>Prescription Drugs - therapeutic use</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Socioeconomic Factors</topic><topic>Togo</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Potchoo, Yao</creatorcontrib><creatorcontrib>Redah, Datouda</creatorcontrib><creatorcontrib>Gneni, Malick A.</creatorcontrib><creatorcontrib>Guissou, Innocent P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Potchoo, Yao</au><au>Redah, Datouda</au><au>Gneni, Malick A.</au><au>Guissou, Innocent P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prescription drugs among pregnant women in Lome, Togo, West Africa</atitle><jtitle>European journal of clinical pharmacology</jtitle><stitle>Eur J Clin Pharmacol</stitle><addtitle>Eur J Clin Pharmacol</addtitle><date>2009-08-01</date><risdate>2009</risdate><volume>65</volume><issue>8</issue><spage>831</spage><epage>838</epage><pages>831-838</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>Objective
To assess the trends in prescription drugs and the potential repercussions to newborns among pregnant women who attended prenatal consultations and gave birth in the Department of Gynaecology of Tokoin’s University Hospital, Lome (Togo).
Methods
A retrospective study of the registers of prenatal visits and deliveries of the eligible population was performed.
Results
In total, 184 different drugs were prescribed to 627 pregnant women attending prenatal consultations. The profile of pharmacotherapeutic groups prescribed was: anti-anaemics (33.33%), antimalarial drugs (24.75%), vitamins ± mineral salts, amino acids and appetite stimulants (14.96%) and antispasmodics and anti-emetics (7.22%). The median proportion of prescriptions for each pharmacotherapeutic group increased significantly from the first to third trimester (9.72, 25.17 and 64.00 respectively;
P
< 0.05). The median number of drugs prescribed did not vary significantly (
P
= 0.051) with the age groups, parity (
P
= 0.068) or obstetrical–gynaecological history (
P
= 0.401); it did, however, increase significantly with the medical–surgical history (
P
< 0.05). There were complications associated with deliveries that had no obvious cause related to drug prescription, including four cases of minor defects, 28 stillborns, 65 cases of low birth weight and 27 hospitalised newborns for neonatal diseases. Some interventions were needed for safeguarding the health of the mother, the foetus and the newborn.
Conclusion
The trends in obtaining prescription drugs and the consumption of drugs by pregnant women can be assessed using multiple parameters. We limited our study to age groups, gestational age, parity and the medical history of the pregnant woman, profile of pharmacotherapeutic groups, median number of drugs prescribed and the potential risks of the drugs used. The results of our retrospective study were not alarming in terms of neonatal outcomes.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19337728</pmid><doi>10.1007/s00228-009-0644-5</doi><tpages>8</tpages></addata></record> |
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| ispartof | European journal of clinical pharmacology, 2009-08, Vol.65 (8), p.831-838 |
| issn | 0031-6970 1432-1041 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Adult Analgesics - therapeutic use Anti-Anxiety Agents - therapeutic use Antiemetics - therapeutic use Antihypertensive Agents - therapeutic use Antimalarials - therapeutic use Antiparasitic Agents - therapeutic use Biological and medical sciences Biomedical and Life Sciences Biomedicine Drug Prescriptions - statistics & numerical data Female Gestational Age Hematinics - therapeutic use Humans Medical sciences Pharmacoepidemiology and Prescription Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Practice Patterns, Physicians' - statistics & numerical data Pregnancy Pregnancy Complications - drug therapy Pregnancy Complications - prevention & control Pregnancy Outcome Pregnancy Trimesters Prenatal care Prescription drugs Prescription Drugs - adverse effects Prescription Drugs - therapeutic use Retrospective Studies Risk factors Socioeconomic Factors Togo Young Adult |
| title | Prescription drugs among pregnant women in Lome, Togo, West Africa |
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