Exacerbation of autoimmune thyroiditis by a single low dose of whole-body irradiation in non-obese diabetic-H2h4 mice

Purpose: To evaluate how irradiation affects thyroid autoimmunity in mouse models of Hashimoto's thyroiditis and Graves' hyperthyroidism. Materials and methods: Non-obese diabetic (NOD)-H2h4 mice spontaneously develop anti-thyroglobulin (Tg) antibodies and thyroiditis when supplied with so...

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Veröffentlicht in:	International journal of radiation biology 2008, Vol.84 (9), p.761-769
Hauptverfasser:	Nagayama, Yuji, Kaminoda, Kazuhisa, Mizutori, Yumiko, Saitoh, Ohki, Abiru, Norio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Animals Antibodies - immunology Disease Models, Animal Female Gene Expression Regulation, Viral Graves Disease - immunology Graves Disease - pathology H-2 Antigens - immunology Hashimoto Disease - chemically induced Hashimoto Disease - immunology Hashimoto Disease - pathology Humans Immunization iodide Mice Mice, Inbred NOD Radiation Dosage Receptors, Thyrotropin - immunology Receptors, Thyrotropin - metabolism T-Lymphocytes - radiation effects thyroglobulin Thyroid autoimmunity Thyroiditis, Autoimmune - immunology Thyroiditis, Autoimmune - pathology thyrotropin receptor Whole-Body Irradiation
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