Exacerbation of autoimmune thyroiditis by a single low dose of whole-body irradiation in non-obese diabetic-H2h4 mice
Purpose: To evaluate how irradiation affects thyroid autoimmunity in mouse models of Hashimoto's thyroiditis and Graves' hyperthyroidism. Materials and methods: Non-obese diabetic (NOD)-H2h4 mice spontaneously develop anti-thyroglobulin (Tg) antibodies and thyroiditis when supplied with so...
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| Veröffentlicht in: | International journal of radiation biology 2008, Vol.84 (9), p.761-769 |
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| container_title | International journal of radiation biology |
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| creator | Nagayama, Yuji Kaminoda, Kazuhisa Mizutori, Yumiko Saitoh, Ohki Abiru, Norio |
| description | Purpose: To evaluate how irradiation affects thyroid autoimmunity in mouse models of Hashimoto's thyroiditis and Graves' hyperthyroidism.
Materials and methods: Non-obese diabetic (NOD)-H2h4 mice spontaneously develop anti-thyroglobulin (Tg) antibodies and thyroiditis when supplied with sodium iodine (NaI) in the drinking water. BALB c mice develop anti-thyrotropin receptor (TSHR) antibodies and hyperthyroidism following immunization with adenovirus expressing TSHR (Ad-TSHR). Mice were irradiated as follows: A single whole-body irradiation with 0.05, 0.5 or 3 Gy one week before or after the beginning of NaI or immunization with Ad-TSHR, fractionated whole-body irradiations with 0.05 Gy twice a week or 0.5 Gy once a week from one week before NaI or Ad-TSHR immunization, or a single regional irradiation to the thyroid gland with 0.5 Gy one week before NaI. The effect of a single irradiation with 0.05, 0.5 or 3 Gy on splenocytes was also evaluated.
Results: A single whole-body irradiation with 0.5 Gy one week before NaI exacerbated thyroiditis and increased anti-Tg antibody titers in NOD-H2h4 mice. In contrast, any irradiation protocols employed did not affect incidence of hyperthyroidism or anti-TSHR antibody titers in BALB c mice. High-dose irradiation increased the relative ratios of effector T cells to regulatory T cells (an indication of enhanced immune status) but kills most of T cells.
Conclusions: These results indicate that a single whole-body low-dose irradiation with 0.5 Gy exacerbates thyroiditis in NOD-H2h4 mice, data consistent with some clinical evidence for increased incidence of thyroid autoimmunity by environmental irradiation. |
| doi_str_mv | 10.1080/09553000802345910 |
| format | Article |
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Materials and methods: Non-obese diabetic (NOD)-H2h4 mice spontaneously develop anti-thyroglobulin (Tg) antibodies and thyroiditis when supplied with sodium iodine (NaI) in the drinking water. BALB c mice develop anti-thyrotropin receptor (TSHR) antibodies and hyperthyroidism following immunization with adenovirus expressing TSHR (Ad-TSHR). Mice were irradiated as follows: A single whole-body irradiation with 0.05, 0.5 or 3 Gy one week before or after the beginning of NaI or immunization with Ad-TSHR, fractionated whole-body irradiations with 0.05 Gy twice a week or 0.5 Gy once a week from one week before NaI or Ad-TSHR immunization, or a single regional irradiation to the thyroid gland with 0.5 Gy one week before NaI. The effect of a single irradiation with 0.05, 0.5 or 3 Gy on splenocytes was also evaluated.
Results: A single whole-body irradiation with 0.5 Gy one week before NaI exacerbated thyroiditis and increased anti-Tg antibody titers in NOD-H2h4 mice. In contrast, any irradiation protocols employed did not affect incidence of hyperthyroidism or anti-TSHR antibody titers in BALB c mice. High-dose irradiation increased the relative ratios of effector T cells to regulatory T cells (an indication of enhanced immune status) but kills most of T cells.
Conclusions: These results indicate that a single whole-body low-dose irradiation with 0.5 Gy exacerbates thyroiditis in NOD-H2h4 mice, data consistent with some clinical evidence for increased incidence of thyroid autoimmunity by environmental irradiation.</description><identifier>ISSN: 0955-3002</identifier><identifier>EISSN: 1362-3095</identifier><identifier>DOI: 10.1080/09553000802345910</identifier><identifier>PMID: 18821390</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adenoviridae - genetics ; Adenovirus ; Animals ; Antibodies - immunology ; Disease Models, Animal ; Female ; Gene Expression Regulation, Viral ; Graves Disease - immunology ; Graves Disease - pathology ; H-2 Antigens - immunology ; Hashimoto Disease - chemically induced ; Hashimoto Disease - immunology ; Hashimoto Disease - pathology ; Humans ; Immunization ; iodide ; Mice ; Mice, Inbred NOD ; Radiation Dosage ; Receptors, Thyrotropin - immunology ; Receptors, Thyrotropin - metabolism ; T-Lymphocytes - radiation effects ; thyroglobulin ; Thyroid autoimmunity ; Thyroiditis, Autoimmune - immunology ; Thyroiditis, Autoimmune - pathology ; thyrotropin receptor ; Whole-Body Irradiation</subject><ispartof>International journal of radiation biology, 2008, Vol.84 (9), p.761-769</ispartof><rights>2008 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09553000802345910$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09553000802345910$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18821390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagayama, Yuji</creatorcontrib><creatorcontrib>Kaminoda, Kazuhisa</creatorcontrib><creatorcontrib>Mizutori, Yumiko</creatorcontrib><creatorcontrib>Saitoh, Ohki</creatorcontrib><creatorcontrib>Abiru, Norio</creatorcontrib><title>Exacerbation of autoimmune thyroiditis by a single low dose of whole-body irradiation in non-obese diabetic-H2h4 mice</title><title>International journal of radiation biology</title><addtitle>Int J Radiat Biol</addtitle><description>Purpose: To evaluate how irradiation affects thyroid autoimmunity in mouse models of Hashimoto's thyroiditis and Graves' hyperthyroidism.
Materials and methods: Non-obese diabetic (NOD)-H2h4 mice spontaneously develop anti-thyroglobulin (Tg) antibodies and thyroiditis when supplied with sodium iodine (NaI) in the drinking water. BALB c mice develop anti-thyrotropin receptor (TSHR) antibodies and hyperthyroidism following immunization with adenovirus expressing TSHR (Ad-TSHR). Mice were irradiated as follows: A single whole-body irradiation with 0.05, 0.5 or 3 Gy one week before or after the beginning of NaI or immunization with Ad-TSHR, fractionated whole-body irradiations with 0.05 Gy twice a week or 0.5 Gy once a week from one week before NaI or Ad-TSHR immunization, or a single regional irradiation to the thyroid gland with 0.5 Gy one week before NaI. The effect of a single irradiation with 0.05, 0.5 or 3 Gy on splenocytes was also evaluated.
Results: A single whole-body irradiation with 0.5 Gy one week before NaI exacerbated thyroiditis and increased anti-Tg antibody titers in NOD-H2h4 mice. In contrast, any irradiation protocols employed did not affect incidence of hyperthyroidism or anti-TSHR antibody titers in BALB c mice. High-dose irradiation increased the relative ratios of effector T cells to regulatory T cells (an indication of enhanced immune status) but kills most of T cells.
Conclusions: These results indicate that a single whole-body low-dose irradiation with 0.5 Gy exacerbates thyroiditis in NOD-H2h4 mice, data consistent with some clinical evidence for increased incidence of thyroid autoimmunity by environmental irradiation.</description><subject>Adenoviridae - genetics</subject><subject>Adenovirus</subject><subject>Animals</subject><subject>Antibodies - immunology</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Gene Expression Regulation, Viral</subject><subject>Graves Disease - immunology</subject><subject>Graves Disease - pathology</subject><subject>H-2 Antigens - immunology</subject><subject>Hashimoto Disease - chemically induced</subject><subject>Hashimoto Disease - immunology</subject><subject>Hashimoto Disease - pathology</subject><subject>Humans</subject><subject>Immunization</subject><subject>iodide</subject><subject>Mice</subject><subject>Mice, Inbred NOD</subject><subject>Radiation Dosage</subject><subject>Receptors, Thyrotropin - immunology</subject><subject>Receptors, Thyrotropin - metabolism</subject><subject>T-Lymphocytes - radiation effects</subject><subject>thyroglobulin</subject><subject>Thyroid autoimmunity</subject><subject>Thyroiditis, Autoimmune - immunology</subject><subject>Thyroiditis, Autoimmune - pathology</subject><subject>thyrotropin receptor</subject><subject>Whole-Body Irradiation</subject><issn>0955-3002</issn><issn>1362-3095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1TAQhS0EoreFB2CDvOourT1OQiK6qapCkSp1A2vLPxPiyrGL7eiSt8dXtywqxGpGc75zpJkh5ANnF5wN7JKNXScYqy2Iths5e0V2XPTQiKq8JruDXnsGJ-Q058dKAhPDW3LChwG4GNmOrLe_lcGkVXEx0DhRtZbolmUNSMu8peisKy5TvVFFsws_PVIf99TGjAd8P0ePjY52oy4lZd0xyAUaYmiixorVocbiTHMHc0sXZ_AdeTMpn_H9cz0jP77cfr-5a-4fvn67ub5vHPSsNACjxbEbRPep5xOg7ljHhGonaEVv6u7cCK45TmCGEfjArGHCArSa90IPvTgj58fcpxR_rZiLXFw26L0KGNcsgQHnvO8q-PEZXPWCVj4lt6i0yb-HqsDVEXBhimlR-5i8lUVtPqYpqWBcloIzefiL_Ocv1f75hX1G5ctsVEL5GNcU6hHk_91_AOh7j7U</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Nagayama, Yuji</creator><creator>Kaminoda, Kazuhisa</creator><creator>Mizutori, Yumiko</creator><creator>Saitoh, Ohki</creator><creator>Abiru, Norio</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>2008</creationdate><title>Exacerbation of autoimmune thyroiditis by a single low dose of whole-body irradiation in non-obese diabetic-H2h4 mice</title><author>Nagayama, Yuji ; Kaminoda, Kazuhisa ; Mizutori, Yumiko ; Saitoh, Ohki ; Abiru, Norio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i260t-229de95835761f2eb50503a4f2436c5531c31b1ef2c892180dc03d224b163b863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adenoviridae - genetics</topic><topic>Adenovirus</topic><topic>Animals</topic><topic>Antibodies - immunology</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Gene Expression Regulation, Viral</topic><topic>Graves Disease - immunology</topic><topic>Graves Disease - pathology</topic><topic>H-2 Antigens - immunology</topic><topic>Hashimoto Disease - chemically induced</topic><topic>Hashimoto Disease - immunology</topic><topic>Hashimoto Disease - pathology</topic><topic>Humans</topic><topic>Immunization</topic><topic>iodide</topic><topic>Mice</topic><topic>Mice, Inbred NOD</topic><topic>Radiation Dosage</topic><topic>Receptors, Thyrotropin - immunology</topic><topic>Receptors, Thyrotropin - metabolism</topic><topic>T-Lymphocytes - radiation effects</topic><topic>thyroglobulin</topic><topic>Thyroid autoimmunity</topic><topic>Thyroiditis, Autoimmune - immunology</topic><topic>Thyroiditis, Autoimmune - pathology</topic><topic>thyrotropin receptor</topic><topic>Whole-Body Irradiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagayama, Yuji</creatorcontrib><creatorcontrib>Kaminoda, Kazuhisa</creatorcontrib><creatorcontrib>Mizutori, Yumiko</creatorcontrib><creatorcontrib>Saitoh, Ohki</creatorcontrib><creatorcontrib>Abiru, Norio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>International journal of radiation biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagayama, Yuji</au><au>Kaminoda, Kazuhisa</au><au>Mizutori, Yumiko</au><au>Saitoh, Ohki</au><au>Abiru, Norio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exacerbation of autoimmune thyroiditis by a single low dose of whole-body irradiation in non-obese diabetic-H2h4 mice</atitle><jtitle>International journal of radiation biology</jtitle><addtitle>Int J Radiat Biol</addtitle><date>2008</date><risdate>2008</risdate><volume>84</volume><issue>9</issue><spage>761</spage><epage>769</epage><pages>761-769</pages><issn>0955-3002</issn><eissn>1362-3095</eissn><abstract>Purpose: To evaluate how irradiation affects thyroid autoimmunity in mouse models of Hashimoto's thyroiditis and Graves' hyperthyroidism.
Materials and methods: Non-obese diabetic (NOD)-H2h4 mice spontaneously develop anti-thyroglobulin (Tg) antibodies and thyroiditis when supplied with sodium iodine (NaI) in the drinking water. BALB c mice develop anti-thyrotropin receptor (TSHR) antibodies and hyperthyroidism following immunization with adenovirus expressing TSHR (Ad-TSHR). Mice were irradiated as follows: A single whole-body irradiation with 0.05, 0.5 or 3 Gy one week before or after the beginning of NaI or immunization with Ad-TSHR, fractionated whole-body irradiations with 0.05 Gy twice a week or 0.5 Gy once a week from one week before NaI or Ad-TSHR immunization, or a single regional irradiation to the thyroid gland with 0.5 Gy one week before NaI. The effect of a single irradiation with 0.05, 0.5 or 3 Gy on splenocytes was also evaluated.
Results: A single whole-body irradiation with 0.5 Gy one week before NaI exacerbated thyroiditis and increased anti-Tg antibody titers in NOD-H2h4 mice. In contrast, any irradiation protocols employed did not affect incidence of hyperthyroidism or anti-TSHR antibody titers in BALB c mice. High-dose irradiation increased the relative ratios of effector T cells to regulatory T cells (an indication of enhanced immune status) but kills most of T cells.
Conclusions: These results indicate that a single whole-body low-dose irradiation with 0.5 Gy exacerbates thyroiditis in NOD-H2h4 mice, data consistent with some clinical evidence for increased incidence of thyroid autoimmunity by environmental irradiation.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>18821390</pmid><doi>10.1080/09553000802345910</doi><tpages>9</tpages></addata></record> |
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| subjects | Adenoviridae - genetics Adenovirus Animals Antibodies - immunology Disease Models, Animal Female Gene Expression Regulation, Viral Graves Disease - immunology Graves Disease - pathology H-2 Antigens - immunology Hashimoto Disease - chemically induced Hashimoto Disease - immunology Hashimoto Disease - pathology Humans Immunization iodide Mice Mice, Inbred NOD Radiation Dosage Receptors, Thyrotropin - immunology Receptors, Thyrotropin - metabolism T-Lymphocytes - radiation effects thyroglobulin Thyroid autoimmunity Thyroiditis, Autoimmune - immunology Thyroiditis, Autoimmune - pathology thyrotropin receptor Whole-Body Irradiation |
| title | Exacerbation of autoimmune thyroiditis by a single low dose of whole-body irradiation in non-obese diabetic-H2h4 mice |
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