ATRA Regulates Innate Immunity in Liver Ischemia/Reperfusion Injury via RARα/Akt/Foxo1 Signaling

All-trans retinoic acid (ATRA) has been proved to protect liver from ischemia/reperfusion (IR) injury, however, its mechanism is still unclear. This study is to investigate the mechanism of effect of ATRA on innate immunity in mice liver IR injury. Before operation, mice were gavaged by ATRA at 15 m...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2018/04/01, Vol.41(4), pp.530-535
Hauptverfasser:	Zhong, Chen, Pu, Liyong, Fang, Mingming, Rao, Jianhua, Wang, Xuehao
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Alanine Alanine transaminase all-trans retinoic acid Apoptosis Aspartate aminotransferase Forkhead box o 1 Forkhead protein FOXO1 protein Inflammation Inflammatory response Innate immunity Interleukin 6 Ischemia ischemia/reperfusion injury Lipopolysaccharides Liver Macrophages Mice Phosphorylation Reperfusion Retinoic acid retinoic acid receptor α Rodents TLR4 protein Toll-like receptors Tumor necrosis factor-α
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