A phase I, open-label, single-dose micro tracer mass balance study of 14C-labeled ASP7991 in healthy Japanese male subjects using accelerator mass spectrometry

ASP7991 is a calcimimetic that acts on the calcium-sensing receptor on parathyroid cell membranes and suppresses parathyroid hormone (PTH) secretion in the treatment of secondary hyperparathyroidism. The mass balance and metabolite profile of [14C]ASP7991 were investigated in six healthy male subjec...

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Veröffentlicht in:	Drug metabolism and pharmacokinetics 2018-04, Vol.33 (2), p.118-124
Hauptverfasser:	Miyatake, Daisuke, Nakada, Naoyuki, Takada, Akitsugu, Kato, Kota, Taniuchi, Yuta, Katashima, Masataka, Sawamoto, Taiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Accelerator mass spectrometry (AMS) ASP7991 Conventional mass balance study Mass balance (MB) study Micro tracer mass balance study
Online-Zugang:	Volltext
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