Particulate matter, oxidative stress and neurotoxicity
Particulate matter (PM), a component of air pollution has been epidemiologically associated with sudden deaths, cardiovascular and respiratory illnesses. The effects are more pronounced in patients with pre-existing conditions such as asthma, diabetes or obstructive pulmonary disorders. Clinical and...
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| Veröffentlicht in: | Neurotoxicology (Park Forest South) 2008-05, Vol.29 (3), p.479-488 |
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| container_title | Neurotoxicology (Park Forest South) |
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| creator | MohanKumar, Sheba M.J. Campbell, Arezoo Block, Michelle Veronesi, Bellina |
| description | Particulate matter (PM), a component of air pollution has been epidemiologically associated with sudden deaths, cardiovascular and respiratory illnesses. The effects are more pronounced in patients with pre-existing conditions such as asthma, diabetes or obstructive pulmonary disorders. Clinical and experimental studies have historically focused on the cardiopulmonary effects of PM. However, since PM particles carry numerous biocontaminants that are capable of triggering free radical production and cytokine release, the possibility that PM may affect organs systems sensitive to oxidative stress must be considered. Four independent studies that summarize the neurochemical and neuropathological changes found in the brains of PM exposed animals are described here. These were recently presented at two 2007 symposia sponsored by the Society of Toxicology (Charlotte, NC) and the International Neurotoxicology Association (Monterey, CA). |
| doi_str_mv | 10.1016/j.neuro.2007.12.004 |
| format | Article |
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| ispartof | Neurotoxicology (Park Forest South), 2008-05, Vol.29 (3), p.479-488 |
| issn | 0161-813X 1872-9711 |
| language | eng |
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| subjects | Animals Biological and medical sciences HPA axis Humans Hypothalamo-Hypophyseal System - drug effects Innate immunity Mac-1 Medical sciences Neurotoxicity Neurotoxicity Syndromes - physiopathology Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Particulate matter Particulate Matter - toxicity Toxicology |
| title | Particulate matter, oxidative stress and neurotoxicity |
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