Air pollution, cognitive deficits and brain abnormalities: A pilot study with children and dogs
Exposure to air pollution is associated with neuroinflammation in healthy children and dogs in Mexico City. Comparative studies were carried out in healthy children and young dogs similarly exposed to ambient pollution in Mexico City. Children from Mexico City (n: 55) and a low polluted city (n:18)...
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| Veröffentlicht in: | Brain and cognition 2008-11, Vol.68 (2), p.117-127 |
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| creator | Calderón-Garcidueñas, Lilian Mora-Tiscareño, Antonieta Ontiveros, Esperanza Gómez-Garza, Gilberto Barragán-Mejía, Gerardo Broadway, James Chapman, Susan Valencia-Salazar, Gildardo Jewells, Valerie Maronpot, Robert R. Henríquez-Roldán, Carlos Pérez-Guillé, Beatriz Torres-Jardón, Ricardo Herrit, Lou Brooks, Diane Osnaya-Brizuela, Norma Monroy, Maria E. González-Maciel, Angelica Reynoso-Robles, Rafael Villarreal-Calderon, Rafael Solt, Anna C Engle, Randall W. |
| description | Exposure to air pollution is associated with neuroinflammation in healthy children and dogs in Mexico City. Comparative studies were carried out in healthy children and young dogs similarly exposed to ambient pollution in Mexico City. Children from Mexico City (n: 55) and a low polluted city (n:18) underwent psychometric testing and brain magnetic resonance imaging MRI. Seven healthy young dogs with similar exposure to Mexico City air pollution had brain MRI, measurement of mRNA abundance of two inflammatory genes cyclooxygenase-2, and interleukin 1 β in target brain areas, and histopathological evaluation of brain tissue. Children with no known risk factors for neurological or cognitive disorders residing in a polluted urban environment exhibited significant deficits in a combination of fluid and crystallized cognition tasks. Fifty-six percent of Mexico City children tested showed prefrontal white matter hyperintense lesions and similar lesions were observed in dogs (57%). Exposed dogs had frontal lesions with vascular subcortical pathology associated with neuroinflammation, enlarged Virchow–Robin spaces, gliosis, and ultrafine particulate matter deposition. Based on the MRI findings, the prefrontal cortex was a target anatomical region in Mexico City children and its damage could have contributed to their cognitive dysfunction. The present work presents a groundbreaking, interdisciplinary methodology for addressing relationships between environmental pollution, structural brain alterations by MRI, and cognitive deficits/delays in healthy children. |
| doi_str_mv | 10.1016/j.bandc.2008.04.008 |
| format | Article |
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Comparative studies were carried out in healthy children and young dogs similarly exposed to ambient pollution in Mexico City. Children from Mexico City (n: 55) and a low polluted city (n:18) underwent psychometric testing and brain magnetic resonance imaging MRI. Seven healthy young dogs with similar exposure to Mexico City air pollution had brain MRI, measurement of mRNA abundance of two inflammatory genes cyclooxygenase-2, and interleukin 1 β in target brain areas, and histopathological evaluation of brain tissue. Children with no known risk factors for neurological or cognitive disorders residing in a polluted urban environment exhibited significant deficits in a combination of fluid and crystallized cognition tasks. Fifty-six percent of Mexico City children tested showed prefrontal white matter hyperintense lesions and similar lesions were observed in dogs (57%). Exposed dogs had frontal lesions with vascular subcortical pathology associated with neuroinflammation, enlarged Virchow–Robin spaces, gliosis, and ultrafine particulate matter deposition. Based on the MRI findings, the prefrontal cortex was a target anatomical region in Mexico City children and its damage could have contributed to their cognitive dysfunction. The present work presents a groundbreaking, interdisciplinary methodology for addressing relationships between environmental pollution, structural brain alterations by MRI, and cognitive deficits/delays in healthy children.</description><identifier>ISSN: 0278-2626</identifier><identifier>EISSN: 1090-2147</identifier><identifier>DOI: 10.1016/j.bandc.2008.04.008</identifier><identifier>PMID: 18550243</identifier><identifier>CODEN: BRCOEI</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adolescent ; Air pollution ; Air Pollution - adverse effects ; Air Pollution - analysis ; Air Pollution - economics ; Animals ; Biological and medical sciences ; Brain ; Brain - metabolism ; Brain - pathology ; Brain - physiopathology ; Brain MRI ; Child ; Children ; Cognition - physiology ; Comparative Analysis ; Cyclooxygenase 2 - genetics ; Dogs ; Endothelial pathology ; Environment. Living conditions ; Environmental Exposure - adverse effects ; Environmental Exposure - analysis ; Female ; Fluid cognition ; Foreign Countries ; Frontal Lobe - metabolism ; Frontal Lobe - pathology ; Frontal Lobe - physiopathology ; Gliosis - etiology ; Gliosis - genetics ; Gliosis - pathology ; Humans ; Interleukin-1beta - genetics ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Mental Disorders - epidemiology ; Mental Disorders - etiology ; Mental Disorders - pathology ; Mexicans ; Mexico (Mexico City) ; Mexico - epidemiology ; Neuroinflammation ; Neurological Impairments ; Neuropsychological Tests - statistics & numerical data ; Particulate Matter - analysis ; Particulate matter PM ; Pilot Projects ; Pollution ; Prefrontal Cortex - metabolism ; Prefrontal Cortex - pathology ; Prefrontal Cortex - physiopathology ; Psychometrics - methods ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Reverse Transcriptase Polymerase Chain Reaction ; Risk Factors ; Ultrafine PM ; Urban Areas ; White matter hyperintense lesions WML</subject><ispartof>Brain and cognition, 2008-11, Vol.68 (2), p.117-127</ispartof><rights>2008 Elsevier Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-de3b0e00a7322aad4a4fa7e983d8096edf9436a0fdcdf9695a59f5b03fcbf54d3</citedby><cites>FETCH-LOGICAL-c439t-de3b0e00a7322aad4a4fa7e983d8096edf9436a0fdcdf9695a59f5b03fcbf54d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0278262608001747$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://eric.ed.gov/ERICWebPortal/detail?accno=EJ815833$$DView record in ERIC$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20939974$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18550243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Calderón-Garcidueñas, Lilian</creatorcontrib><creatorcontrib>Mora-Tiscareño, Antonieta</creatorcontrib><creatorcontrib>Ontiveros, Esperanza</creatorcontrib><creatorcontrib>Gómez-Garza, Gilberto</creatorcontrib><creatorcontrib>Barragán-Mejía, Gerardo</creatorcontrib><creatorcontrib>Broadway, James</creatorcontrib><creatorcontrib>Chapman, Susan</creatorcontrib><creatorcontrib>Valencia-Salazar, Gildardo</creatorcontrib><creatorcontrib>Jewells, Valerie</creatorcontrib><creatorcontrib>Maronpot, Robert R.</creatorcontrib><creatorcontrib>Henríquez-Roldán, Carlos</creatorcontrib><creatorcontrib>Pérez-Guillé, Beatriz</creatorcontrib><creatorcontrib>Torres-Jardón, Ricardo</creatorcontrib><creatorcontrib>Herrit, Lou</creatorcontrib><creatorcontrib>Brooks, Diane</creatorcontrib><creatorcontrib>Osnaya-Brizuela, Norma</creatorcontrib><creatorcontrib>Monroy, Maria E.</creatorcontrib><creatorcontrib>González-Maciel, Angelica</creatorcontrib><creatorcontrib>Reynoso-Robles, Rafael</creatorcontrib><creatorcontrib>Villarreal-Calderon, Rafael</creatorcontrib><creatorcontrib>Solt, Anna C</creatorcontrib><creatorcontrib>Engle, Randall W.</creatorcontrib><title>Air pollution, cognitive deficits and brain abnormalities: A pilot study with children and dogs</title><title>Brain and cognition</title><addtitle>Brain Cogn</addtitle><description>Exposure to air pollution is associated with neuroinflammation in healthy children and dogs in Mexico City. Comparative studies were carried out in healthy children and young dogs similarly exposed to ambient pollution in Mexico City. Children from Mexico City (n: 55) and a low polluted city (n:18) underwent psychometric testing and brain magnetic resonance imaging MRI. Seven healthy young dogs with similar exposure to Mexico City air pollution had brain MRI, measurement of mRNA abundance of two inflammatory genes cyclooxygenase-2, and interleukin 1 β in target brain areas, and histopathological evaluation of brain tissue. Children with no known risk factors for neurological or cognitive disorders residing in a polluted urban environment exhibited significant deficits in a combination of fluid and crystallized cognition tasks. Fifty-six percent of Mexico City children tested showed prefrontal white matter hyperintense lesions and similar lesions were observed in dogs (57%). Exposed dogs had frontal lesions with vascular subcortical pathology associated with neuroinflammation, enlarged Virchow–Robin spaces, gliosis, and ultrafine particulate matter deposition. Based on the MRI findings, the prefrontal cortex was a target anatomical region in Mexico City children and its damage could have contributed to their cognitive dysfunction. The present work presents a groundbreaking, interdisciplinary methodology for addressing relationships between environmental pollution, structural brain alterations by MRI, and cognitive deficits/delays in healthy children.</description><subject>Adolescent</subject><subject>Air pollution</subject><subject>Air Pollution - adverse effects</subject><subject>Air Pollution - analysis</subject><subject>Air Pollution - economics</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Brain MRI</subject><subject>Child</subject><subject>Children</subject><subject>Cognition - physiology</subject><subject>Comparative Analysis</subject><subject>Cyclooxygenase 2 - genetics</subject><subject>Dogs</subject><subject>Endothelial pathology</subject><subject>Environment. Living conditions</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental Exposure - analysis</subject><subject>Female</subject><subject>Fluid cognition</subject><subject>Foreign Countries</subject><subject>Frontal Lobe - metabolism</subject><subject>Frontal Lobe - pathology</subject><subject>Frontal Lobe - physiopathology</subject><subject>Gliosis - etiology</subject><subject>Gliosis - genetics</subject><subject>Gliosis - pathology</subject><subject>Humans</subject><subject>Interleukin-1beta - genetics</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental Disorders - epidemiology</subject><subject>Mental Disorders - etiology</subject><subject>Mental Disorders - pathology</subject><subject>Mexicans</subject><subject>Mexico (Mexico City)</subject><subject>Mexico - epidemiology</subject><subject>Neuroinflammation</subject><subject>Neurological Impairments</subject><subject>Neuropsychological Tests - statistics & numerical data</subject><subject>Particulate Matter - analysis</subject><subject>Particulate matter PM</subject><subject>Pilot Projects</subject><subject>Pollution</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Prefrontal Cortex - pathology</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychometrics - methods</subject><subject>Public health. Hygiene</subject><subject>Public health. 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Comparative studies were carried out in healthy children and young dogs similarly exposed to ambient pollution in Mexico City. Children from Mexico City (n: 55) and a low polluted city (n:18) underwent psychometric testing and brain magnetic resonance imaging MRI. Seven healthy young dogs with similar exposure to Mexico City air pollution had brain MRI, measurement of mRNA abundance of two inflammatory genes cyclooxygenase-2, and interleukin 1 β in target brain areas, and histopathological evaluation of brain tissue. Children with no known risk factors for neurological or cognitive disorders residing in a polluted urban environment exhibited significant deficits in a combination of fluid and crystallized cognition tasks. Fifty-six percent of Mexico City children tested showed prefrontal white matter hyperintense lesions and similar lesions were observed in dogs (57%). Exposed dogs had frontal lesions with vascular subcortical pathology associated with neuroinflammation, enlarged Virchow–Robin spaces, gliosis, and ultrafine particulate matter deposition. Based on the MRI findings, the prefrontal cortex was a target anatomical region in Mexico City children and its damage could have contributed to their cognitive dysfunction. The present work presents a groundbreaking, interdisciplinary methodology for addressing relationships between environmental pollution, structural brain alterations by MRI, and cognitive deficits/delays in healthy children.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>18550243</pmid><doi>10.1016/j.bandc.2008.04.008</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-2626 |
| ispartof | Brain and cognition, 2008-11, Vol.68 (2), p.117-127 |
| issn | 0278-2626 1090-2147 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_20206022 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Air pollution Air Pollution - adverse effects Air Pollution - analysis Air Pollution - economics Animals Biological and medical sciences Brain Brain - metabolism Brain - pathology Brain - physiopathology Brain MRI Child Children Cognition - physiology Comparative Analysis Cyclooxygenase 2 - genetics Dogs Endothelial pathology Environment. Living conditions Environmental Exposure - adverse effects Environmental Exposure - analysis Female Fluid cognition Foreign Countries Frontal Lobe - metabolism Frontal Lobe - pathology Frontal Lobe - physiopathology Gliosis - etiology Gliosis - genetics Gliosis - pathology Humans Interleukin-1beta - genetics Magnetic Resonance Imaging Male Medical sciences Mental Disorders - epidemiology Mental Disorders - etiology Mental Disorders - pathology Mexicans Mexico (Mexico City) Mexico - epidemiology Neuroinflammation Neurological Impairments Neuropsychological Tests - statistics & numerical data Particulate Matter - analysis Particulate matter PM Pilot Projects Pollution Prefrontal Cortex - metabolism Prefrontal Cortex - pathology Prefrontal Cortex - physiopathology Psychometrics - methods Public health. Hygiene Public health. Hygiene-occupational medicine Reverse Transcriptase Polymerase Chain Reaction Risk Factors Ultrafine PM Urban Areas White matter hyperintense lesions WML |
| title | Air pollution, cognitive deficits and brain abnormalities: A pilot study with children and dogs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T00%3A05%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Air%20pollution,%20cognitive%20deficits%20and%20brain%20abnormalities:%20A%20pilot%20study%20with%20children%20and%20dogs&rft.jtitle=Brain%20and%20cognition&rft.au=Calder%C3%B3n-Garcidue%C3%B1as,%20Lilian&rft.date=2008-11-01&rft.volume=68&rft.issue=2&rft.spage=117&rft.epage=127&rft.pages=117-127&rft.issn=0278-2626&rft.eissn=1090-2147&rft.coden=BRCOEI&rft_id=info:doi/10.1016/j.bandc.2008.04.008&rft_dat=%3Cproquest_cross%3E20206022%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20206022&rft_id=info:pmid/18550243&rft_ericid=EJ815833&rft_els_id=S0278262608001747&rfr_iscdi=true |