Amyloid-producing Odontoameloblastoma in a Black-tailed Prairie Dog (Cynomys ludovicianus)

Amyloid-producing Odontoameloblastoma in a Black-tailed Prairie Dog (Cynomys ludovicianus)

A 6-year-old female black-tailed prairie dog (Cynomys ludovicianus) was presented with a space-occupying lesion in the left submandibular region. On computed tomography, a low attenuating, poorly circumscribed mass infiltrated the left mandibular bone, with osteolytic change. Microscopically, the le...

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Veröffentlicht in:Journal of comparative pathology 2018-02, Vol.159, p.26-30
Hauptverfasser: Kok, M.K., Chambers, J.K., Ushio, N., Miwa, Y., Nakayama, H., Uchida, K.
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amyloid
odontogenic tumour
prairie dog
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container_issue
container_start_page 26
container_title Journal of comparative pathology
container_volume 159
creator Kok, M.K.
Chambers, J.K.
Ushio, N.
Miwa, Y.
Nakayama, H.
Uchida, K.
description A 6-year-old female black-tailed prairie dog (Cynomys ludovicianus) was presented with a space-occupying lesion in the left submandibular region. On computed tomography, a low attenuating, poorly circumscribed mass infiltrated the left mandibular bone, with osteolytic change. Microscopically, the lesion was composed of odontogenic epithelium proliferating in nests and embedded in abundant dental papilla-like ectomesenchyme, including dentine and enamel. Multifocal amyloid deposition was observed. Immunohistochemically, the neoplastic epithelial cells were positive for cytokeratin (CK) AE1/AE3, CK14 and p63. Some epithelial cells were positive for amelogenin and some adjacent to the amyloid deposits co-expressed S100. The ectomesenchymal cells expressed vimentin and strong S100 immunoreactivity was observed in odontoblast-like cells. The amyloid was immunolabelled with amelogenin. The tumour was diagnosed as amyloid-producing odontoameloblastoma.
doi_str_mv 10.1016/j.jcpa.2017.12.002
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subjects amyloid
odontogenic tumour
prairie dog
title Amyloid-producing Odontoameloblastoma in a Black-tailed Prairie Dog (Cynomys ludovicianus)
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