A unique signal sequence of the chemokine receptor CCR7 promotes package into COPII vesicles for efficient receptor trafficking

Chemokine receptors are considered to belong to the group of G protein‐coupled receptors that use the first transmembrane domain as signal anchor sequence for membrane insertion instead of a cleavable N‐terminal signal sequence. Chemokine recognition is determined by the N‐termini of chemokine recep...

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Veröffentlicht in:	Journal of leukocyte biology 2018-08, Vol.104 (2), p.375-389
Hauptverfasser:	Uetz‐von Allmen, Edith, Rippl, Alexandra V., Farhan, Hesso, Legler, Daniel F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cell migration COP-Coated Vesicles - metabolism G protein‐coupled receptor Golgi Humans ligand binding Mice protein export Protein Sorting Signals - physiology Protein Transport - physiology Receptors, CCR7 - chemistry Receptors, CCR7 - metabolism
Online-Zugang:	Volltext
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