Concordance of somatic mutational profile in multiple primary melanomas
Summary This study aimed to determine the frequency and concordance of BRAF and NRAS mutation in tumours arising in patients with multiple primary melanoma (MPM). Patients with MPM managed at one of three tertiary referral centres in Melbourne, Australia, from 2010 to 2015 were included. Incident an...
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| Veröffentlicht in: | Pigment cell and melanoma research 2018-09, Vol.31 (5), p.592-603 |
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| container_title | Pigment cell and melanoma research |
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| creator | Adler, Nikki R. McLean, Catriona A. Wolfe, Rory Kelly, John W. McArthur, Grant A. Haydon, Andrew Tra, Thien Cummings, Nicholas Mar, Victoria J. |
| description | Summary
This study aimed to determine the frequency and concordance of BRAF and NRAS mutation in tumours arising in patients with multiple primary melanoma (MPM). Patients with MPM managed at one of three tertiary referral centres in Melbourne, Australia, from 2010 to 2015 were included. Incident and subsequent melanomas underwent mutation testing. Cohen's kappa (κ) coefficient assessed agreement between incident and subsequent primary melanomas for both BRAF and NRAS mutation status (mutant versus wild‐type). Mutation testing of at least two primary tumours from 64 patients was conducted. There was poor agreement for both BRAF and NRAS mutation status between incident and subsequent melanomas (κ = 0.10, 95% CI −0.10 to 0.42; κ = 0.06, 95% CI −0.10 to 0.57, respectively). In view of the low concordance in BRAF mutation status between incident and subsequent melanomas, mutational analysis of metastatic tissue, rather than of a primary melanoma, in patients with MPM should be used to guide targeted therapy. |
| doi_str_mv | 10.1111/pcmr.12702 |
| format | Article |
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This study aimed to determine the frequency and concordance of BRAF and NRAS mutation in tumours arising in patients with multiple primary melanoma (MPM). Patients with MPM managed at one of three tertiary referral centres in Melbourne, Australia, from 2010 to 2015 were included. Incident and subsequent melanomas underwent mutation testing. Cohen's kappa (κ) coefficient assessed agreement between incident and subsequent primary melanomas for both BRAF and NRAS mutation status (mutant versus wild‐type). Mutation testing of at least two primary tumours from 64 patients was conducted. There was poor agreement for both BRAF and NRAS mutation status between incident and subsequent melanomas (κ = 0.10, 95% CI −0.10 to 0.42; κ = 0.06, 95% CI −0.10 to 0.57, respectively). In view of the low concordance in BRAF mutation status between incident and subsequent melanomas, mutational analysis of metastatic tissue, rather than of a primary melanoma, in patients with MPM should be used to guide targeted therapy.</description><identifier>ISSN: 1755-1471</identifier><identifier>EISSN: 1755-148X</identifier><identifier>DOI: 10.1111/pcmr.12702</identifier><identifier>PMID: 29603877</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>BRAF mutation ; Melanoma ; Metastases ; multiple primary melanoma ; Mutation ; mutation status ; Patients ; Tumors</subject><ispartof>Pigment cell and melanoma research, 2018-09, Vol.31 (5), p.592-603</ispartof><rights>2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2018 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3932-4c74df9720bf94f75ca82def21beaa7a4acb0b751a1ed088577273961e2c562b3</citedby><cites>FETCH-LOGICAL-c3932-4c74df9720bf94f75ca82def21beaa7a4acb0b751a1ed088577273961e2c562b3</cites><orcidid>0000-0002-7972-9050</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpcmr.12702$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpcmr.12702$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29603877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adler, Nikki R.</creatorcontrib><creatorcontrib>McLean, Catriona A.</creatorcontrib><creatorcontrib>Wolfe, Rory</creatorcontrib><creatorcontrib>Kelly, John W.</creatorcontrib><creatorcontrib>McArthur, Grant A.</creatorcontrib><creatorcontrib>Haydon, Andrew</creatorcontrib><creatorcontrib>Tra, Thien</creatorcontrib><creatorcontrib>Cummings, Nicholas</creatorcontrib><creatorcontrib>Mar, Victoria J.</creatorcontrib><title>Concordance of somatic mutational profile in multiple primary melanomas</title><title>Pigment cell and melanoma research</title><addtitle>Pigment Cell Melanoma Res</addtitle><description>Summary
This study aimed to determine the frequency and concordance of BRAF and NRAS mutation in tumours arising in patients with multiple primary melanoma (MPM). Patients with MPM managed at one of three tertiary referral centres in Melbourne, Australia, from 2010 to 2015 were included. Incident and subsequent melanomas underwent mutation testing. Cohen's kappa (κ) coefficient assessed agreement between incident and subsequent primary melanomas for both BRAF and NRAS mutation status (mutant versus wild‐type). Mutation testing of at least two primary tumours from 64 patients was conducted. There was poor agreement for both BRAF and NRAS mutation status between incident and subsequent melanomas (κ = 0.10, 95% CI −0.10 to 0.42; κ = 0.06, 95% CI −0.10 to 0.57, respectively). In view of the low concordance in BRAF mutation status between incident and subsequent melanomas, mutational analysis of metastatic tissue, rather than of a primary melanoma, in patients with MPM should be used to guide targeted therapy.</description><subject>BRAF mutation</subject><subject>Melanoma</subject><subject>Metastases</subject><subject>multiple primary melanoma</subject><subject>Mutation</subject><subject>mutation status</subject><subject>Patients</subject><subject>Tumors</subject><issn>1755-1471</issn><issn>1755-148X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMo7rp68QdIwYsIXZP0Y9qjFF2FFUUUvIU0TaBL26xJi-y_d9aue_BgLjMMT15mHkLOGZ0zfDdr1bo540D5AZkySJKQxdnH4b4HNiEn3q8oTWmSR8dkwvOURhnAlCwK2ynrKtkpHVgTeNvKvlZBO_RYbSebYO2sqRsd1B1Om75eY792dSvdJmh1Izv84k_JkZGN12e7OiPv93dvxUO4fF48FrfLUEV5xMNYQVyZHDgtTR4bSJTMeKUNZ6WWEmQsVUlLSJhkuqJZlgBwiPKUaa6SlJfRjFyNubjV56B9L9raK93gGtoOXnDKaZxTFIDo5R90ZQeHF22pLEVzEQBS1yOlnPXeaSN2twlGxVav2OoVP3oRvthFDmWrqz366xMBNgJfaGzzT5R4KZ5ex9Bv6uyE_g</recordid><startdate>201809</startdate><enddate>201809</enddate><creator>Adler, Nikki R.</creator><creator>McLean, Catriona A.</creator><creator>Wolfe, Rory</creator><creator>Kelly, John W.</creator><creator>McArthur, Grant A.</creator><creator>Haydon, Andrew</creator><creator>Tra, Thien</creator><creator>Cummings, Nicholas</creator><creator>Mar, Victoria J.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7972-9050</orcidid></search><sort><creationdate>201809</creationdate><title>Concordance of somatic mutational profile in multiple primary melanomas</title><author>Adler, Nikki R. ; McLean, Catriona A. ; Wolfe, Rory ; Kelly, John W. ; McArthur, Grant A. ; Haydon, Andrew ; Tra, Thien ; Cummings, Nicholas ; Mar, Victoria J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3932-4c74df9720bf94f75ca82def21beaa7a4acb0b751a1ed088577273961e2c562b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>BRAF mutation</topic><topic>Melanoma</topic><topic>Metastases</topic><topic>multiple primary melanoma</topic><topic>Mutation</topic><topic>mutation status</topic><topic>Patients</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adler, Nikki R.</creatorcontrib><creatorcontrib>McLean, Catriona A.</creatorcontrib><creatorcontrib>Wolfe, Rory</creatorcontrib><creatorcontrib>Kelly, John W.</creatorcontrib><creatorcontrib>McArthur, Grant A.</creatorcontrib><creatorcontrib>Haydon, Andrew</creatorcontrib><creatorcontrib>Tra, Thien</creatorcontrib><creatorcontrib>Cummings, Nicholas</creatorcontrib><creatorcontrib>Mar, Victoria J.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pigment cell and melanoma research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adler, Nikki R.</au><au>McLean, Catriona A.</au><au>Wolfe, Rory</au><au>Kelly, John W.</au><au>McArthur, Grant A.</au><au>Haydon, Andrew</au><au>Tra, Thien</au><au>Cummings, Nicholas</au><au>Mar, Victoria J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Concordance of somatic mutational profile in multiple primary melanomas</atitle><jtitle>Pigment cell and melanoma research</jtitle><addtitle>Pigment Cell Melanoma Res</addtitle><date>2018-09</date><risdate>2018</risdate><volume>31</volume><issue>5</issue><spage>592</spage><epage>603</epage><pages>592-603</pages><issn>1755-1471</issn><eissn>1755-148X</eissn><abstract>Summary
This study aimed to determine the frequency and concordance of BRAF and NRAS mutation in tumours arising in patients with multiple primary melanoma (MPM). Patients with MPM managed at one of three tertiary referral centres in Melbourne, Australia, from 2010 to 2015 were included. Incident and subsequent melanomas underwent mutation testing. Cohen's kappa (κ) coefficient assessed agreement between incident and subsequent primary melanomas for both BRAF and NRAS mutation status (mutant versus wild‐type). Mutation testing of at least two primary tumours from 64 patients was conducted. There was poor agreement for both BRAF and NRAS mutation status between incident and subsequent melanomas (κ = 0.10, 95% CI −0.10 to 0.42; κ = 0.06, 95% CI −0.10 to 0.57, respectively). In view of the low concordance in BRAF mutation status between incident and subsequent melanomas, mutational analysis of metastatic tissue, rather than of a primary melanoma, in patients with MPM should be used to guide targeted therapy.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29603877</pmid><doi>10.1111/pcmr.12702</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-7972-9050</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley-Blackwell Journals |
| subjects | BRAF mutation Melanoma Metastases multiple primary melanoma Mutation mutation status Patients Tumors |
| title | Concordance of somatic mutational profile in multiple primary melanomas |
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