Poly(ethylene glycol) diacrylate based monolithic capillary columns for the analysis of polar small solutes by capillary electrochromatography
Monolithic stationary phases based on poly(ethylene glycol) diacrylates for capillary electrochromatography were developed. Several poly(ethylene glycol) diacrylates (Mn 250, 575, and 700) were used as single monomers and the resulting columns were carefully compared. Methanol and ethyl ether were s...
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| Veröffentlicht in: | Journal of separation science 2018-06, Vol.41 (12), p.2632-2639 |
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| container_title | Journal of separation science |
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| creator | Vergara‐Barberán, María Mompó‐Roselló, Óscar Herrero‐Martínez, José Manuel Simó‐Alfonso, Ernesto Francisco |
| description | Monolithic stationary phases based on poly(ethylene glycol) diacrylates for capillary electrochromatography were developed. Several poly(ethylene glycol) diacrylates (Mn 250, 575, and 700) were used as single monomers and the resulting columns were carefully compared. Methanol and ethyl ether were selected as porogenic solvents, and in all cases ultraviolet radiation was selected as initiation method to prepare polymeric monoliths. The influence of the monomer chain length and ratio monomer/porogen on the morphological and electrochromatographic properties of the resulting monoliths was investigated. Several families of compounds with different polarity (alkyl benzenes, organophosphorous pesticides, benzoic acid derivatives, and sulfonamides) were selected to evaluate the performance of the fabricated monolithic columns. The best results were obtained for poly(ethylene glycol) diacrylate 700 monoliths affording efficiencies of 144 000 plates/m for retained polar aromatic small molecules and excellent reproducibility in column preparation (RSD values below 2.5%). |
| doi_str_mv | 10.1002/jssc.201800184 |
| format | Article |
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Several poly(ethylene glycol) diacrylates (Mn 250, 575, and 700) were used as single monomers and the resulting columns were carefully compared. Methanol and ethyl ether were selected as porogenic solvents, and in all cases ultraviolet radiation was selected as initiation method to prepare polymeric monoliths. The influence of the monomer chain length and ratio monomer/porogen on the morphological and electrochromatographic properties of the resulting monoliths was investigated. Several families of compounds with different polarity (alkyl benzenes, organophosphorous pesticides, benzoic acid derivatives, and sulfonamides) were selected to evaluate the performance of the fabricated monolithic columns. The best results were obtained for poly(ethylene glycol) diacrylate 700 monoliths affording efficiencies of 144 000 plates/m for retained polar aromatic small molecules and excellent reproducibility in column preparation (RSD values below 2.5%).</description><identifier>ISSN: 1615-9306</identifier><identifier>EISSN: 1615-9314</identifier><identifier>DOI: 10.1002/jssc.201800184</identifier><identifier>PMID: 29603908</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Benzoic acid ; capillary electrochromatography ; Columns (process) ; Electrochromatography ; Molecular chains ; Monomers ; Pesticides ; polar compounds ; Polarity ; poly(ethylene glycol) diacrylate ; Polyethylene glycol ; polymeric monoliths ; Reproducibility ; Sulfonamides ; Ultraviolet radiation</subject><ispartof>Journal of separation science, 2018-06, Vol.41 (12), p.2632-2639</ispartof><rights>2018 WILEY‐VCH Verlag GmbH & Co. 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Several poly(ethylene glycol) diacrylates (Mn 250, 575, and 700) were used as single monomers and the resulting columns were carefully compared. Methanol and ethyl ether were selected as porogenic solvents, and in all cases ultraviolet radiation was selected as initiation method to prepare polymeric monoliths. The influence of the monomer chain length and ratio monomer/porogen on the morphological and electrochromatographic properties of the resulting monoliths was investigated. Several families of compounds with different polarity (alkyl benzenes, organophosphorous pesticides, benzoic acid derivatives, and sulfonamides) were selected to evaluate the performance of the fabricated monolithic columns. 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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Benzoic acid capillary electrochromatography Columns (process) Electrochromatography Molecular chains Monomers Pesticides polar compounds Polarity poly(ethylene glycol) diacrylate Polyethylene glycol polymeric monoliths Reproducibility Sulfonamides Ultraviolet radiation |
| title | Poly(ethylene glycol) diacrylate based monolithic capillary columns for the analysis of polar small solutes by capillary electrochromatography |
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