Myocardial fibrosis evaluated by diffusion‐weighted imaging and its relationship to 3D contractile function in patients with hypertrophic cardiomyopathy
Background Previous studies have shown that diffusion‐weighted imaging (DWI) is sensitive to myocardial fibrosis in ischemic and nonischemic cardiomyopathy. Purpose To explore the prognostic value of apparent diffusion coefficient (ADC) for detecting myocardial fibrosis and its relationship to the c...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2018-10, Vol.48 (4), p.1139-1146 |
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| creator | Wu, Rui An, Dong‐Aolei Shi, Ruo‐Yang Chen, Bing‐hua Jiang, Meng Bacyinski, Andrew Han, Tong‐Tong Hu, Jiani Xu, Jian‐Rong Wu, Lian‐Ming |
| description | Background
Previous studies have shown that diffusion‐weighted imaging (DWI) is sensitive to myocardial fibrosis in ischemic and nonischemic cardiomyopathy.
Purpose
To explore the prognostic value of apparent diffusion coefficient (ADC) for detecting myocardial fibrosis and its relationship to the contractile function in hypertrophic cardiomyopathy (HCM).
Study Type
Prospective.
Population
A total of 45 HCM patients and 20 controls.
Field Strength/Sequence
3.0T cardiac MRI. The cardiac MR sequences included cine, T1 mapping, and DWI.
Assessment
According to the presence of late gadolinium enhancement (LGE) and the extracellular volume (ECV) values (+2 SD of control subjects), respectively, reader W and reader J assessed the value of ADC of each segment for detecting myocardial fibrosis and its relationship to impaired contractile function in HCM patients.
Statistical Tests
Independent sample t‐test, Pearson analysis, and intraclass correlation (ICC).
Results
The value of ECV was 23.6 ± 3.0% for control. ECV ≥ 29.6% and ECV |
| doi_str_mv | 10.1002/jmri.26016 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2020489145</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2020489145</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3576-1127c27122b6f4b7ff04b62eca57c2d80083a7819a813db91d6039dc1890b8d93</originalsourceid><addsrcrecordid>eNp9kctu1TAQhi1ERS-w4QGQJTaoUooviWMvUbkVtUJCsLYcX058lMTBdnqUHY_AmsfjSfDpKV2wYDWjmW9-jf4fgOcYXWCEyOvtGP0FYQizR-AEN4RUpOHscelRQyvMUXsMTlPaIoSEqJsn4JiIQmMqTsCvmzVoFY1XA3S-iyH5BO2tGhaVrYHdCo13bkk-TL9__NxZv-n3cz-qjZ82UE2lzwlGO6hcmNT7GeYA6Vuow5Sj0tkPFrpl0vs19BOcC2incrPzuYf9OtuYY5h7r-HdI2FcQ2H69Sk4cmpI9tl9PQPf3r_7evmxuv784eryzXWladOyCmPSatJiQjrm6q51DtUdI1arpswNR4hT1XIsFMfUdAIbhqgwGnOBOm4EPQOvDrpzDN8Xm7IcfdJ2GNRkw5IkQQTVXOC6KejLf9BtWOJUvpMEY8YEaRAt1PmB0sXOFK2TcyyGxVViJPeJyX1i8i6xAr-4l1y60ZoH9G9EBcAHYFecXP8jJT_dfLk6iP4B4-ik0A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2116692503</pqid></control><display><type>article</type><title>Myocardial fibrosis evaluated by diffusion‐weighted imaging and its relationship to 3D contractile function in patients with hypertrophic cardiomyopathy</title><source>Wiley Free Content</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Wu, Rui ; An, Dong‐Aolei ; Shi, Ruo‐Yang ; Chen, Bing‐hua ; Jiang, Meng ; Bacyinski, Andrew ; Han, Tong‐Tong ; Hu, Jiani ; Xu, Jian‐Rong ; Wu, Lian‐Ming</creator><creatorcontrib>Wu, Rui ; An, Dong‐Aolei ; Shi, Ruo‐Yang ; Chen, Bing‐hua ; Jiang, Meng ; Bacyinski, Andrew ; Han, Tong‐Tong ; Hu, Jiani ; Xu, Jian‐Rong ; Wu, Lian‐Ming</creatorcontrib><description>Background
Previous studies have shown that diffusion‐weighted imaging (DWI) is sensitive to myocardial fibrosis in ischemic and nonischemic cardiomyopathy.
Purpose
To explore the prognostic value of apparent diffusion coefficient (ADC) for detecting myocardial fibrosis and its relationship to the contractile function in hypertrophic cardiomyopathy (HCM).
Study Type
Prospective.
Population
A total of 45 HCM patients and 20 controls.
Field Strength/Sequence
3.0T cardiac MRI. The cardiac MR sequences included cine, T1 mapping, and DWI.
Assessment
According to the presence of late gadolinium enhancement (LGE) and the extracellular volume (ECV) values (+2 SD of control subjects), respectively, reader W and reader J assessed the value of ADC of each segment for detecting myocardial fibrosis and its relationship to impaired contractile function in HCM patients.
Statistical Tests
Independent sample t‐test, Pearson analysis, and intraclass correlation (ICC).
Results
The value of ECV was 23.6 ± 3.0% for control. ECV ≥ 29.6% and ECV < 29.6% groups were classified. ADC values in the ECV ≥ 29.6% group were significantly increased compared to the ECV < 29.6% group, (2.41 ± 0.23 μm2/ms vs. 2.03 ± 0.16 μm2/ms, P < 0.005). Compared to the LGE – group, ECV (32.1 ± 2.3% vs. 29.0 ± 2.8%, P < 0.005) and ADC (2.60 ± 0.18 μm2/ms vs. 2.10 ± 0.07 μm2/ms, P < 0.005) values were significantly increased in the LGE + group. ADC values were linearly associated with ECV values (R2 = 0.65) in HCM patients. ADC values were linearly associated with circumferential and longitudinal strain (R2 = 0.60, R2 = 0.46), as well as circumferential, longitudinal, and radial strain rate (R2 = 0.13, R2 = 0.25, R2 = 0.17, respectively).
Data Conclusion
Contractile dysfunction in HCM is predominantly associated with ADC, which is a feasible alternative to ECV and LGE for detecting myocardial fibrosis.
Level of Evidence: 1
Technical Efficacy: Stage 2
J. Magn. Reson. Imaging 2018;48:1139–1146.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.26016</identifier><identifier>PMID: 29601139</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>apparent diffusion coefficient ; Cardiomyopathy ; Correlation analysis ; Diffusion ; Diffusion coefficient ; DWI ; ECV ; Fibrosis ; Field strength ; Gadolinium ; HCM ; Heart ; Ischemia ; LGE ; Magnetic resonance imaging ; Medical imaging ; Muscle contraction ; Patients ; Population (statistical) ; Population studies ; Statistical analysis ; Statistical tests ; Strain rate ; tissue tracking</subject><ispartof>Journal of magnetic resonance imaging, 2018-10, Vol.48 (4), p.1139-1146</ispartof><rights>2018 International Society for Magnetic Resonance in Medicine</rights><rights>2018 International Society for Magnetic Resonance in Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3576-1127c27122b6f4b7ff04b62eca57c2d80083a7819a813db91d6039dc1890b8d93</citedby><cites>FETCH-LOGICAL-c3576-1127c27122b6f4b7ff04b62eca57c2d80083a7819a813db91d6039dc1890b8d93</cites><orcidid>0000-0002-2718-8416</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.26016$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.26016$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29601139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Rui</creatorcontrib><creatorcontrib>An, Dong‐Aolei</creatorcontrib><creatorcontrib>Shi, Ruo‐Yang</creatorcontrib><creatorcontrib>Chen, Bing‐hua</creatorcontrib><creatorcontrib>Jiang, Meng</creatorcontrib><creatorcontrib>Bacyinski, Andrew</creatorcontrib><creatorcontrib>Han, Tong‐Tong</creatorcontrib><creatorcontrib>Hu, Jiani</creatorcontrib><creatorcontrib>Xu, Jian‐Rong</creatorcontrib><creatorcontrib>Wu, Lian‐Ming</creatorcontrib><title>Myocardial fibrosis evaluated by diffusion‐weighted imaging and its relationship to 3D contractile function in patients with hypertrophic cardiomyopathy</title><title>Journal of magnetic resonance imaging</title><addtitle>J Magn Reson Imaging</addtitle><description>Background
Previous studies have shown that diffusion‐weighted imaging (DWI) is sensitive to myocardial fibrosis in ischemic and nonischemic cardiomyopathy.
Purpose
To explore the prognostic value of apparent diffusion coefficient (ADC) for detecting myocardial fibrosis and its relationship to the contractile function in hypertrophic cardiomyopathy (HCM).
Study Type
Prospective.
Population
A total of 45 HCM patients and 20 controls.
Field Strength/Sequence
3.0T cardiac MRI. The cardiac MR sequences included cine, T1 mapping, and DWI.
Assessment
According to the presence of late gadolinium enhancement (LGE) and the extracellular volume (ECV) values (+2 SD of control subjects), respectively, reader W and reader J assessed the value of ADC of each segment for detecting myocardial fibrosis and its relationship to impaired contractile function in HCM patients.
Statistical Tests
Independent sample t‐test, Pearson analysis, and intraclass correlation (ICC).
Results
The value of ECV was 23.6 ± 3.0% for control. ECV ≥ 29.6% and ECV < 29.6% groups were classified. ADC values in the ECV ≥ 29.6% group were significantly increased compared to the ECV < 29.6% group, (2.41 ± 0.23 μm2/ms vs. 2.03 ± 0.16 μm2/ms, P < 0.005). Compared to the LGE – group, ECV (32.1 ± 2.3% vs. 29.0 ± 2.8%, P < 0.005) and ADC (2.60 ± 0.18 μm2/ms vs. 2.10 ± 0.07 μm2/ms, P < 0.005) values were significantly increased in the LGE + group. ADC values were linearly associated with ECV values (R2 = 0.65) in HCM patients. ADC values were linearly associated with circumferential and longitudinal strain (R2 = 0.60, R2 = 0.46), as well as circumferential, longitudinal, and radial strain rate (R2 = 0.13, R2 = 0.25, R2 = 0.17, respectively).
Data Conclusion
Contractile dysfunction in HCM is predominantly associated with ADC, which is a feasible alternative to ECV and LGE for detecting myocardial fibrosis.
Level of Evidence: 1
Technical Efficacy: Stage 2
J. Magn. Reson. Imaging 2018;48:1139–1146.</description><subject>apparent diffusion coefficient</subject><subject>Cardiomyopathy</subject><subject>Correlation analysis</subject><subject>Diffusion</subject><subject>Diffusion coefficient</subject><subject>DWI</subject><subject>ECV</subject><subject>Fibrosis</subject><subject>Field strength</subject><subject>Gadolinium</subject><subject>HCM</subject><subject>Heart</subject><subject>Ischemia</subject><subject>LGE</subject><subject>Magnetic resonance imaging</subject><subject>Medical imaging</subject><subject>Muscle contraction</subject><subject>Patients</subject><subject>Population (statistical)</subject><subject>Population studies</subject><subject>Statistical analysis</subject><subject>Statistical tests</subject><subject>Strain rate</subject><subject>tissue tracking</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kctu1TAQhi1ERS-w4QGQJTaoUooviWMvUbkVtUJCsLYcX058lMTBdnqUHY_AmsfjSfDpKV2wYDWjmW9-jf4fgOcYXWCEyOvtGP0FYQizR-AEN4RUpOHscelRQyvMUXsMTlPaIoSEqJsn4JiIQmMqTsCvmzVoFY1XA3S-iyH5BO2tGhaVrYHdCo13bkk-TL9__NxZv-n3cz-qjZ82UE2lzwlGO6hcmNT7GeYA6Vuow5Sj0tkPFrpl0vs19BOcC2incrPzuYf9OtuYY5h7r-HdI2FcQ2H69Sk4cmpI9tl9PQPf3r_7evmxuv784eryzXWladOyCmPSatJiQjrm6q51DtUdI1arpswNR4hT1XIsFMfUdAIbhqgwGnOBOm4EPQOvDrpzDN8Xm7IcfdJ2GNRkw5IkQQTVXOC6KejLf9BtWOJUvpMEY8YEaRAt1PmB0sXOFK2TcyyGxVViJPeJyX1i8i6xAr-4l1y60ZoH9G9EBcAHYFecXP8jJT_dfLk6iP4B4-ik0A</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Wu, Rui</creator><creator>An, Dong‐Aolei</creator><creator>Shi, Ruo‐Yang</creator><creator>Chen, Bing‐hua</creator><creator>Jiang, Meng</creator><creator>Bacyinski, Andrew</creator><creator>Han, Tong‐Tong</creator><creator>Hu, Jiani</creator><creator>Xu, Jian‐Rong</creator><creator>Wu, Lian‐Ming</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2718-8416</orcidid></search><sort><creationdate>201810</creationdate><title>Myocardial fibrosis evaluated by diffusion‐weighted imaging and its relationship to 3D contractile function in patients with hypertrophic cardiomyopathy</title><author>Wu, Rui ; An, Dong‐Aolei ; Shi, Ruo‐Yang ; Chen, Bing‐hua ; Jiang, Meng ; Bacyinski, Andrew ; Han, Tong‐Tong ; Hu, Jiani ; Xu, Jian‐Rong ; Wu, Lian‐Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3576-1127c27122b6f4b7ff04b62eca57c2d80083a7819a813db91d6039dc1890b8d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>apparent diffusion coefficient</topic><topic>Cardiomyopathy</topic><topic>Correlation analysis</topic><topic>Diffusion</topic><topic>Diffusion coefficient</topic><topic>DWI</topic><topic>ECV</topic><topic>Fibrosis</topic><topic>Field strength</topic><topic>Gadolinium</topic><topic>HCM</topic><topic>Heart</topic><topic>Ischemia</topic><topic>LGE</topic><topic>Magnetic resonance imaging</topic><topic>Medical imaging</topic><topic>Muscle contraction</topic><topic>Patients</topic><topic>Population (statistical)</topic><topic>Population studies</topic><topic>Statistical analysis</topic><topic>Statistical tests</topic><topic>Strain rate</topic><topic>tissue tracking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Rui</creatorcontrib><creatorcontrib>An, Dong‐Aolei</creatorcontrib><creatorcontrib>Shi, Ruo‐Yang</creatorcontrib><creatorcontrib>Chen, Bing‐hua</creatorcontrib><creatorcontrib>Jiang, Meng</creatorcontrib><creatorcontrib>Bacyinski, Andrew</creatorcontrib><creatorcontrib>Han, Tong‐Tong</creatorcontrib><creatorcontrib>Hu, Jiani</creatorcontrib><creatorcontrib>Xu, Jian‐Rong</creatorcontrib><creatorcontrib>Wu, Lian‐Ming</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Rui</au><au>An, Dong‐Aolei</au><au>Shi, Ruo‐Yang</au><au>Chen, Bing‐hua</au><au>Jiang, Meng</au><au>Bacyinski, Andrew</au><au>Han, Tong‐Tong</au><au>Hu, Jiani</au><au>Xu, Jian‐Rong</au><au>Wu, Lian‐Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial fibrosis evaluated by diffusion‐weighted imaging and its relationship to 3D contractile function in patients with hypertrophic cardiomyopathy</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J Magn Reson Imaging</addtitle><date>2018-10</date><risdate>2018</risdate><volume>48</volume><issue>4</issue><spage>1139</spage><epage>1146</epage><pages>1139-1146</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Background
Previous studies have shown that diffusion‐weighted imaging (DWI) is sensitive to myocardial fibrosis in ischemic and nonischemic cardiomyopathy.
Purpose
To explore the prognostic value of apparent diffusion coefficient (ADC) for detecting myocardial fibrosis and its relationship to the contractile function in hypertrophic cardiomyopathy (HCM).
Study Type
Prospective.
Population
A total of 45 HCM patients and 20 controls.
Field Strength/Sequence
3.0T cardiac MRI. The cardiac MR sequences included cine, T1 mapping, and DWI.
Assessment
According to the presence of late gadolinium enhancement (LGE) and the extracellular volume (ECV) values (+2 SD of control subjects), respectively, reader W and reader J assessed the value of ADC of each segment for detecting myocardial fibrosis and its relationship to impaired contractile function in HCM patients.
Statistical Tests
Independent sample t‐test, Pearson analysis, and intraclass correlation (ICC).
Results
The value of ECV was 23.6 ± 3.0% for control. ECV ≥ 29.6% and ECV < 29.6% groups were classified. ADC values in the ECV ≥ 29.6% group were significantly increased compared to the ECV < 29.6% group, (2.41 ± 0.23 μm2/ms vs. 2.03 ± 0.16 μm2/ms, P < 0.005). Compared to the LGE – group, ECV (32.1 ± 2.3% vs. 29.0 ± 2.8%, P < 0.005) and ADC (2.60 ± 0.18 μm2/ms vs. 2.10 ± 0.07 μm2/ms, P < 0.005) values were significantly increased in the LGE + group. ADC values were linearly associated with ECV values (R2 = 0.65) in HCM patients. ADC values were linearly associated with circumferential and longitudinal strain (R2 = 0.60, R2 = 0.46), as well as circumferential, longitudinal, and radial strain rate (R2 = 0.13, R2 = 0.25, R2 = 0.17, respectively).
Data Conclusion
Contractile dysfunction in HCM is predominantly associated with ADC, which is a feasible alternative to ECV and LGE for detecting myocardial fibrosis.
Level of Evidence: 1
Technical Efficacy: Stage 2
J. Magn. Reson. Imaging 2018;48:1139–1146.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29601139</pmid><doi>10.1002/jmri.26016</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2718-8416</orcidid></addata></record> |
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| source | Wiley Free Content; Wiley Online Library Journals Frontfile Complete |
| subjects | apparent diffusion coefficient Cardiomyopathy Correlation analysis Diffusion Diffusion coefficient DWI ECV Fibrosis Field strength Gadolinium HCM Heart Ischemia LGE Magnetic resonance imaging Medical imaging Muscle contraction Patients Population (statistical) Population studies Statistical analysis Statistical tests Strain rate tissue tracking |
| title | Myocardial fibrosis evaluated by diffusion‐weighted imaging and its relationship to 3D contractile function in patients with hypertrophic cardiomyopathy |
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