Depression comorbidity in epileptic rats is related to brain glucose hypometabolism and hypersynchronicity in the metabolic network architecture

Summary Objective Temporal lobe epilepsy (TLE) is one of the most common types of epilepsy syndromes in the world. Depression is an important comorbidity of epilepsy, which has been reported in patients with TLE and in different experimental models of epilepsy. However, there is no established conse...

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Veröffentlicht in:	Epilepsia (Copenhagen) 2018-05, Vol.59 (5), p.923-934
Hauptverfasser:	Zanirati, Gabriele, Azevedo, Pamella Nunes, Venturin, Gianina Teribele, Greggio, Samuel, Alcará, Allan Marinho, Zimmer, Eduardo R., Feltes, Paula Kopschina, DaCosta, Jaderson Costa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Brain Brain - metabolism Brain - physiopathology Comorbidity Depression - etiology Depression - metabolism depressive‐like behavior Epilepsy Epilepsy - metabolism Epilepsy - physiopathology Epilepsy - psychology Glucose Glucose - metabolism Image Interpretation, Computer-Assisted Male Mental depression Metabolism microPET neuroimage Neuroimaging Pilocarpine Positron emission tomography Rats Rats, Wistar Rodents Sucrose Temporal lobe
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