Site-specific effect of polar functional group-modification in lipids of TLR2 ligands for modulating the ligand immunostimulatory activity

[Display omitted] Toll-like receptor 2 (TLR2), a member of the TLR innate immune receptor family, recognizes lipoproteins from bacteria and modulates the immune response by inducing the expression of various cytokines. TLR2 has a large hydrophobic pocket that recognizes long fatty acyl groups on TLR...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2018-05, Vol.28 (9), p.1638-1641
Hauptverfasser:	Arai, Yohei, Inuki, Shinsuke, Fujimoto, Yukari
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - chemical synthesis Adjuvants, Immunologic - chemistry Adjuvants, Immunologic - pharmacology Animals Cytokines - biosynthesis Dose-Response Relationship, Drug Humans Hydrophobic and Hydrophilic Interactions Ligands Lipids - chemical synthesis Lipids - chemistry Lipids - pharmacology Lipopeptide Macrophages - drug effects Macrophages - immunology Mice Molecular Structure Pam2CSK4 RAW 264.7 Cells Structure-Activity Relationship Toll-like receptor 2 Toll-Like Receptor 2 - antagonists & inhibitors Toll-Like Receptor 2 - immunology
Online-Zugang:	Volltext
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