Intratumoral and peritumoral lymphovascular invasion detected by D2-40 immunohistochemistry correlates with metastasis in primary cutaneous Merkel cell carcinoma

Primary cutaneous Merkel cell carcinoma (MCC) is an aggressive neuroendocrine malignancy in which lymphovascular invasion (LVI) correlates with more aggressive phenotype. The prognostic significance of LVI detected by D2-40 immunohistochemistry (IHC) in MCC remains controversial. We aimed to determi...

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Veröffentlicht in:	Human pathology 2018-07, Vol.77, p.98-107
Hauptverfasser:	Al-Rohil, Rami N., Milton, Denái R., Nagarajan, Priyadharsini, Curry, Jonathan L., Feldmeyer, Laurence, Torres-Cabala, Carlos A., Ivan, Doina, Prieto, Victor G., Tetzlaff, Michael T., Aung, Phyu P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Biomarkers, Tumor - analysis Carcinoma, Merkel Cell - diagnosis Carcinoma, Merkel Cell - metabolism D2-40 Endothelium Female Humans Immunohistochemistry - methods Intratumoral Lymphatic Metastasis - pathology Lymphatic system Lymphatic Vessels - pathology Lymphovascular invasion Male Medical prognosis Melanoma Merkel cell carcinoma Metastasis Middle Aged Neoplasm Invasiveness - pathology Patients Peritumoral Prognosis Skin cancer Skin Neoplasms - diagnosis Skin Neoplasms - metabolism Skin Neoplasms - pathology
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