Simultaneous determination of eight bioactive compounds by LC-MS/MS and its application to the pharmacokinetics, liver first-pass effect, liver and brain distribution of orally administrated Gouteng-Baitouweng (GB) in rats

Only focusing on the circulating levels is insufficient for the comprehensive understanding of the physiological disposition of herbal medicine in vivo. Therefore, we conducted the comprehensive investigation on the in vivo dynamic process of orally administrated Gouteng-Baitouweng (GB), a classical...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2018-05, Vol.1084, p.122-131
Hauptverfasser:	Tian, Xiaoting, Xu, Zhou, Chen, Mingcang, Hu, Pei, Liu, Fang, Sun, Zhaolin, Liu, Huan, Guo, Xiaozheng, Li, Zhixiong, Huang, Chenggang
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Gouteng-Baitouweng LC-MS/MS Liver Liver first-pass effect Pharmacokinetics
Online-Zugang:	Volltext
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