Review: Exploring functional genomics for drug target and therapeutics discovery in Plasmodia

Review: Exploring functional genomics for drug target and therapeutics discovery in Plasmodia

Functional genomics approaches are indispensable tools in the drug discovery arena and have recently attained increased attention in antibacterial drug discovery research. However, the application of functional genomics to post-genomics research of Plasmodia is still in comparatively early stages. N...

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Veröffentlicht in:Acta tropica 2008-02, Vol.105 (2), p.113-123
Hauptverfasser: Birkholtz, L, van Brummelen, A C, Clark, K, Niemand, J, Marechal, E, Llinas, M, Louw, A I
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container_end_page 123
container_issue 2
container_start_page 113
container_title Acta tropica
container_volume 105
creator Birkholtz, L
van Brummelen, A C
Clark, K
Niemand, J
Marechal, E
Llinas, M
Louw, A I
description Functional genomics approaches are indispensable tools in the drug discovery arena and have recently attained increased attention in antibacterial drug discovery research. However, the application of functional genomics to post-genomics research of Plasmodia is still in comparatively early stages. Nonetheless, with this genus having the most species sequenced of any eukaryotic organism so far, the Plasmodia could provide unique opportunities for the study of intracellular eukaryotic pathogens. This review presents the status quo of functional genomics of the malaria parasite including descriptions of the transcriptome, proteome and interactome. We provide examples for the in silico mining of the X-ome data sets and illustrate how X-omic data from drug challenged parasites might be used in elucidating amongst others, the mode-of-action of inhibitory compounds, validate potential targets and discover novel targets/therapeutics.
doi_str_mv 10.1016/j.actatropica.2007.10.013
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title Review: Exploring functional genomics for drug target and therapeutics discovery in Plasmodia
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