Timed Sexual Intercourse Facilitates the Recruitment of Uterine CD56bright Natural Killer Cells in Women with Infertility

Timed Sexual Intercourse Facilitates the Recruitment of Uterine CD56bright Natural Killer Cells in Women with Infertility

Problem The aim of this study was to investigate the influence of sexual intercourse on uterine NK cell subsets.Method of study Mid-secretory endometrial samples obtained from 56 women were submitted for flow cytometric analysis. Basal body temperature was used to determine the day of ovulation. A t...

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Veröffentlicht in:American journal of reproductive immunology (1989) 2009-08, Vol.62 (2), p.118-124
Hauptverfasser: Kimura, Hidetaka, Fukui, Atsushi, Fujii, Shunsaku, Yamaguchi, Eiji, Kasai, Goichiro, Mizunuma, Hideki
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container_end_page 124
container_issue 2
container_start_page 118
container_title American journal of reproductive immunology (1989)
container_volume 62
creator Kimura, Hidetaka
Fukui, Atsushi
Fujii, Shunsaku
Yamaguchi, Eiji
Kasai, Goichiro
Mizunuma, Hideki
description Problem The aim of this study was to investigate the influence of sexual intercourse on uterine NK cell subsets.Method of study Mid-secretory endometrial samples obtained from 56 women were submitted for flow cytometric analysis. Basal body temperature was used to determine the day of ovulation. A total of 27 women had sexual intercourse before ovulation (pre-ovulation group) and eight women had only after ovulation (post-ovulation group) without any contraceptive devices. A total of 21 women did not have sexual intercourse during the experimental cycle (abstinence group). Endometrial NK cells were analyzed for the expression of CD16 and CD56 using 3-color flow cytometry.Results CD16--CD56bright cells were markedly increased in the pre-ovulation group as compared with that of the post-ovulation group (P < 0.01) and the abstinence group (P < 0.01). CD16+-CD56dim cells were significantly decreased in the pre-ovulation group as compared with that of the post-ovulation group (P < 0.01) and the abstinence group (P < 0.05).Conclusion It is suggested that seminal plasma participates in the recruitment of CD56bright NK cells into endometrium.
doi_str_mv 10.1111/j.1600-0897.2009.00720.x
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Basal body temperature was used to determine the day of ovulation. A total of 27 women had sexual intercourse before ovulation (pre-ovulation group) and eight women had only after ovulation (post-ovulation group) without any contraceptive devices. A total of 21 women did not have sexual intercourse during the experimental cycle (abstinence group). Endometrial NK cells were analyzed for the expression of CD16 and CD56 using 3-color flow cytometry.Results CD16--CD56bright cells were markedly increased in the pre-ovulation group as compared with that of the post-ovulation group (P &lt; 0.01) and the abstinence group (P &lt; 0.01). CD16+-CD56dim cells were significantly decreased in the pre-ovulation group as compared with that of the post-ovulation group (P &lt; 0.01) and the abstinence group (P &lt; 0.05).Conclusion It is suggested that seminal plasma participates in the recruitment of CD56bright NK cells into endometrium.</description><identifier>ISSN: 1046-7408</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1111/j.1600-0897.2009.00720.x</identifier><language>eng</language><ispartof>American journal of reproductive immunology (1989), 2009-08, Vol.62 (2), p.118-124</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Kimura, Hidetaka</creatorcontrib><creatorcontrib>Fukui, Atsushi</creatorcontrib><creatorcontrib>Fujii, Shunsaku</creatorcontrib><creatorcontrib>Yamaguchi, Eiji</creatorcontrib><creatorcontrib>Kasai, Goichiro</creatorcontrib><creatorcontrib>Mizunuma, Hideki</creatorcontrib><title>Timed Sexual Intercourse Facilitates the Recruitment of Uterine CD56bright Natural Killer Cells in Women with Infertility</title><title>American journal of reproductive immunology (1989)</title><description>Problem The aim of this study was to investigate the influence of sexual intercourse on uterine NK cell subsets.Method of study Mid-secretory endometrial samples obtained from 56 women were submitted for flow cytometric analysis. Basal body temperature was used to determine the day of ovulation. A total of 27 women had sexual intercourse before ovulation (pre-ovulation group) and eight women had only after ovulation (post-ovulation group) without any contraceptive devices. A total of 21 women did not have sexual intercourse during the experimental cycle (abstinence group). Endometrial NK cells were analyzed for the expression of CD16 and CD56 using 3-color flow cytometry.Results CD16--CD56bright cells were markedly increased in the pre-ovulation group as compared with that of the post-ovulation group (P &lt; 0.01) and the abstinence group (P &lt; 0.01). CD16+-CD56dim cells were significantly decreased in the pre-ovulation group as compared with that of the post-ovulation group (P &lt; 0.01) and the abstinence group (P &lt; 0.05).Conclusion It is suggested that seminal plasma participates in the recruitment of CD56bright NK cells into endometrium.</description><issn>1046-7408</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNjU9PwzAMxSMEEuPPd_CJW4ObjXY7FyYQEgfYtOMUiks9pQ0kjti-PUFCnPE72LLf-1kpKFGXua53uqwQC5wvam0QFxqxNqj3R2rydzjOM86qop7h_FSdxbhDzPtpPVGHFQ_0Bi-0T9bBwygUWp9CJFjalh2LFYogPcEztSGxDDQK-A7W2ckjQXN7U70Gfu8FnqykkCmP7BwFaMi5CDzCxucQfLH0-UFHQX64hwt10lkX6fK3n6ur5d2quS8-gv9MFGU7cGwzw47kU9wazKqMmf7b-A1ADlkU</recordid><startdate>20090801</startdate><enddate>20090801</enddate><creator>Kimura, Hidetaka</creator><creator>Fukui, Atsushi</creator><creator>Fujii, Shunsaku</creator><creator>Yamaguchi, Eiji</creator><creator>Kasai, Goichiro</creator><creator>Mizunuma, Hideki</creator><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20090801</creationdate><title>Timed Sexual Intercourse Facilitates the Recruitment of Uterine CD56bright Natural Killer Cells in Women with Infertility</title><author>Kimura, Hidetaka ; Fukui, Atsushi ; Fujii, Shunsaku ; Yamaguchi, Eiji ; Kasai, Goichiro ; Mizunuma, Hideki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_202026223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kimura, Hidetaka</creatorcontrib><creatorcontrib>Fukui, Atsushi</creatorcontrib><creatorcontrib>Fujii, Shunsaku</creatorcontrib><creatorcontrib>Yamaguchi, Eiji</creatorcontrib><creatorcontrib>Kasai, Goichiro</creatorcontrib><creatorcontrib>Mizunuma, Hideki</creatorcontrib><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kimura, Hidetaka</au><au>Fukui, Atsushi</au><au>Fujii, Shunsaku</au><au>Yamaguchi, Eiji</au><au>Kasai, Goichiro</au><au>Mizunuma, Hideki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Timed Sexual Intercourse Facilitates the Recruitment of Uterine CD56bright Natural Killer Cells in Women with Infertility</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><date>2009-08-01</date><risdate>2009</risdate><volume>62</volume><issue>2</issue><spage>118</spage><epage>124</epage><pages>118-124</pages><issn>1046-7408</issn><eissn>1600-0897</eissn><abstract>Problem The aim of this study was to investigate the influence of sexual intercourse on uterine NK cell subsets.Method of study Mid-secretory endometrial samples obtained from 56 women were submitted for flow cytometric analysis. 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CD16+-CD56dim cells were significantly decreased in the pre-ovulation group as compared with that of the post-ovulation group (P &lt; 0.01) and the abstinence group (P &lt; 0.05).Conclusion It is suggested that seminal plasma participates in the recruitment of CD56bright NK cells into endometrium.</abstract><doi>10.1111/j.1600-0897.2009.00720.x</doi></addata></record>
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source Wiley Online Library Journals Frontfile Complete
title Timed Sexual Intercourse Facilitates the Recruitment of Uterine CD56bright Natural Killer Cells in Women with Infertility
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