Revisiting cangitoxin, a sea anemone peptide: Purification and characterization of cangitoxins II and III from the venom of Bunodosoma cangicum

Sodium channel toxins from sea anemones are employed as tools for dissecting the biophysical properties of inactivation in voltage-gated sodium channels. Cangitoxin (CGTX) is a peptide containing 48 amino acid residues and was formerly purified from Bunodosoma cangicum. Nevertheless, previous works...

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Veröffentlicht in:	Toxicon (Oxford) 2008-06, Vol.51 (7), p.1303-1307
Hauptverfasser:	Zaharenko, André Junqueira, Ferreira, Wilson Alves, de Oliveira, Joacir Stolarz, Konno, Katsuhiro, Richardson, Michael, Schiavon, Emanuele, Wanke, Enzo, de Freitas, José Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animal poisons toxicology. Antivenoms Animals Biological and medical sciences Bunodosoma cangicum Cangitoxin Cells, Cultured Chemical Fractionation Cnidarian Venoms - chemistry Cnidarian Venoms - toxicity Edman sequencing Ganglia, Spinal - drug effects Ganglia, Spinal - physiology HPLC Humans Marine Medical sciences Molecular Sequence Data Neurotoxins - chemistry Neurotoxins - toxicity Patch clamp Patch-Clamp Techniques Peptide Fragments - chemistry Protein Isoforms Rats Rats, Wistar Sea anemone Sea Anemones Sodium Channels - drug effects Structure-Activity Relationship Toxicology
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