Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes

Nutrients, such as amino acids and glucose, signal through the Rag GTPases to activate mTORC1. The GATOR1 protein complex—comprising DEPDC5, NPRL2 and NPRL3—regulates the Rag GTPases as a GTPase-activating protein (GAP) for RAGA; loss of GATOR1 desensitizes mTORC1 signalling to nutrient starvation....

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Veröffentlicht in:	Nature (London) 2018-04, Vol.556 (7699), p.64-69
Hauptverfasser:	Shen, Kuang, Huang, Rick K., Brignole, Edward J., Condon, Kendall J., Valenstein, Max L., Chantranupong, Lynne, Bomaliyamu, Aimaiti, Choe, Abigail, Hong, Chuan, Yu, Zhiheng, Sabatini, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 631/45/173 631/535/1258/1259 631/80/86/2369 82/80 82/83 Amino acids Amino Acids - deficiency Architecture Cryoelectron Microscopy Crystal structure Desensitization Electron microscopy GTPase-activating protein GTPase-Activating Proteins - antagonists & inhibitors GTPase-Activating Proteins - chemistry GTPase-Activating Proteins - metabolism GTPase-Activating Proteins - ultrastructure Guanosine triphosphatases Guanosine triphosphate Guanosine Triphosphate - metabolism Homology Humanities and Social Sciences Humans Hydrolysis Kinases Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors Mechanistic Target of Rapamycin Complex 1 - metabolism Microscopy Models, Molecular Monomeric GTP-Binding Proteins - chemistry Monomeric GTP-Binding Proteins - metabolism Monomeric GTP-Binding Proteins - ultrastructure multidisciplinary Multiprotein Complexes - antagonists & inhibitors Multiprotein Complexes - chemistry Multiprotein Complexes - metabolism Multiprotein Complexes - ultrastructure Nutrient loss Nutrients Protein Binding Protein Domains Protein Multimerization Protein Subunits - chemistry Protein Subunits - metabolism Proteins Repressor Proteins - chemistry Repressor Proteins - metabolism Repressor Proteins - ultrastructure Science Signal transduction Signaling Substrates Tumor Suppressor Proteins - chemistry Tumor Suppressor Proteins - metabolism Tumor Suppressor Proteins - ultrastructure
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