Synthesis and Structure–Activity Relationships of the Novel Antimalarials 5‑Pyridinyl-4(1H)‑Pyridones

Malaria is still one of the most prevalent parasitic infections in the world, with half of the world’s population at risk for malaria. The effectiveness of current antimalarial therapies, even that of the most recent class of antimalarial drugs (artemisinin-combination therapies, ACTs), is under con...

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Veröffentlicht in:	Journal of medicinal chemistry 2018-04, Vol.61 (8), p.3422-3435
Hauptverfasser:	Bueno, José M, Calderon, Félix, Chicharro, Jesús, De la Rosa, Juan C, Díaz, Beatriz, Fernández, Jorge, Fiandor, José M, Fraile, María T, García, Mercedes, Herreros, Esperanza, García-Pérez, Adolfo, Lorenzo, Milagros, Mallo, Araceli, Puente, Margarita, Saadeddin, Anas, Ferrer, Santiago, Angulo-Barturen, Iñigo, Burrows, Jeremy N, León, María L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - chemical synthesis Antimalarials - chemistry Antimalarials - pharmacokinetics Antimalarials - pharmacology Female Mice Molecular Structure Parasitic Sensitivity Tests Plasmodium falciparum - drug effects Plasmodium yoelii - drug effects Pyridones - chemical synthesis Pyridones - chemistry Pyridones - pharmacokinetics Pyridones - pharmacology Structure-Activity Relationship
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