Urinary stone risk factors in the descendants of patients with kidney stone disease
Background Evidence has indicated that immediate family members of nephrolithiasis patients had high opportunity to develop stones. However, they are usually not regarded to be at risk, since it is unclear if there are any lithogenic abnormalities found in non-stone-forming nephrolithiasis relatives...
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| Veröffentlicht in: | Pediatric nephrology (Berlin, West) West), 2018-07, Vol.33 (7), p.1173-1181 |
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| creator | Dissayabutra, Thasinas Kalpongkul, Nuttiya Rattanaphan, Jakkhaphan Boonla, Chanchai Srisa-art, Monpicha Ungjaroenwathana, Wattanachai Tosukhowong, Piyaratana |
| description | Background
Evidence has indicated that immediate family members of nephrolithiasis patients had high opportunity to develop stones. However, they are usually not regarded to be at risk, since it is unclear if there are any lithogenic abnormalities found in non-stone-forming nephrolithiasis relatives. Our aim was to investigate urinary metabolic abnormalities in the children of nephrolithiasis patients, compared with the general population.
Methods
The 24-h urinary metabolic profile was studied for 28 calcium oxalate nephrolithiasis patients (NL) and 46 of their descendants (ND), as well as 40 non-stone-forming volunteers (V) and 34 of their descendants (VD).
Results
There was no difference between age, gender, and serum creatinine between NL vs. V (parental groups) and ND vs. VD (descendant groups). High urinary oxalate in nephrolithiasis and urinary calcium in their descendants was detected. In addition, an elevated urinary excretion rate of calcium, phosphate, protein, and albumin, along with low citrate excretion and high urinary supersaturation was observed in both the nephrolithiasis patients and their descendants. Approximate 17.8–24.4% of the nephrolithiasis descendants had a urinary supersaturation higher than the nephrolithiasis level, but none was found in VD group. The level of urinary supersaturation index was correlated with urinary protein and albumin excretion in nephrolithiasis family.
Conclusion
It was demonstrated that nephrolithiasis offspring carried several urinary metabolic risks predisposing to stone formation which are similar to their parents, and about one in every five nephrolithiasis children had nephrolithiasis level urinary supersaturation. |
| doi_str_mv | 10.1007/s00467-018-3927-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2019810051</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2019810051</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-8a95dcfc8e51d9b68c438493b3dde7411ed2a543442c70af3a659dc40fcdb1fa3</originalsourceid><addsrcrecordid>eNp1kE1LAzEQhoMoWqs_wIsEvHhZnWyS3c1RxC8QPGjBW0iTWY222ZpsEf-9WVsVBE8ZyPO-MzyEHDA4YQD1aQIQVV0AawquyrpgG2TEBC8LpprHTTICxVkBgj3ukN2UXgCgkU21TXZKJZWQIEfkfhJ9MPGDpr4LSKNPr7Q1tu9ioj7Q_hmpw2QxOBP6RLuWLkzvcZjfff9MX70L-J12PqFJuEe2WjNLuL9-x2RyefFwfl3c3l3dnJ_dFpbXZV80RklnW9ugZE5Nq8YK3gjFp9w5rAVj6EojBReitDWYlptKKmcFtNZNWWv4mByvehexe1ti6vXc51NnMxOwWyZdQvaQRUmW0aM_6Eu3jCFf90UxVUkYKLaibOxSitjqRfTzbEcz0INxvTKus3E9GNdD5nDdvJzO0f0kvhVnoFwBKX-FJ4y_q_9v_QQqLIwI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2019196501</pqid></control><display><type>article</type><title>Urinary stone risk factors in the descendants of patients with kidney stone disease</title><source>SpringerNature Journals</source><creator>Dissayabutra, Thasinas ; Kalpongkul, Nuttiya ; Rattanaphan, Jakkhaphan ; Boonla, Chanchai ; Srisa-art, Monpicha ; Ungjaroenwathana, Wattanachai ; Tosukhowong, Piyaratana</creator><creatorcontrib>Dissayabutra, Thasinas ; Kalpongkul, Nuttiya ; Rattanaphan, Jakkhaphan ; Boonla, Chanchai ; Srisa-art, Monpicha ; Ungjaroenwathana, Wattanachai ; Tosukhowong, Piyaratana</creatorcontrib><description>Background
Evidence has indicated that immediate family members of nephrolithiasis patients had high opportunity to develop stones. However, they are usually not regarded to be at risk, since it is unclear if there are any lithogenic abnormalities found in non-stone-forming nephrolithiasis relatives. Our aim was to investigate urinary metabolic abnormalities in the children of nephrolithiasis patients, compared with the general population.
Methods
The 24-h urinary metabolic profile was studied for 28 calcium oxalate nephrolithiasis patients (NL) and 46 of their descendants (ND), as well as 40 non-stone-forming volunteers (V) and 34 of their descendants (VD).
Results
There was no difference between age, gender, and serum creatinine between NL vs. V (parental groups) and ND vs. VD (descendant groups). High urinary oxalate in nephrolithiasis and urinary calcium in their descendants was detected. In addition, an elevated urinary excretion rate of calcium, phosphate, protein, and albumin, along with low citrate excretion and high urinary supersaturation was observed in both the nephrolithiasis patients and their descendants. Approximate 17.8–24.4% of the nephrolithiasis descendants had a urinary supersaturation higher than the nephrolithiasis level, but none was found in VD group. The level of urinary supersaturation index was correlated with urinary protein and albumin excretion in nephrolithiasis family.
Conclusion
It was demonstrated that nephrolithiasis offspring carried several urinary metabolic risks predisposing to stone formation which are similar to their parents, and about one in every five nephrolithiasis children had nephrolithiasis level urinary supersaturation.</description><identifier>ISSN: 0931-041X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/s00467-018-3927-1</identifier><identifier>PMID: 29594505</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Albumin ; Calcium (urinary) ; Calcium oxalate ; Calcium phosphates ; Children ; Citric acid ; Creatinine ; Excretion ; Families & family life ; Kidney stones ; Medicine ; Medicine & Public Health ; Metabolism ; Nephrolithiasis ; Nephrology ; Original Article ; Oxalic acid ; Pediatrics ; Risk factors ; Sexually transmitted diseases ; STD ; Urology</subject><ispartof>Pediatric nephrology (Berlin, West), 2018-07, Vol.33 (7), p.1173-1181</ispartof><rights>IPNA 2018</rights><rights>Pediatric Nephrology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-8a95dcfc8e51d9b68c438493b3dde7411ed2a543442c70af3a659dc40fcdb1fa3</citedby><cites>FETCH-LOGICAL-c372t-8a95dcfc8e51d9b68c438493b3dde7411ed2a543442c70af3a659dc40fcdb1fa3</cites><orcidid>0000-0001-7066-0870</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00467-018-3927-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00467-018-3927-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29594505$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dissayabutra, Thasinas</creatorcontrib><creatorcontrib>Kalpongkul, Nuttiya</creatorcontrib><creatorcontrib>Rattanaphan, Jakkhaphan</creatorcontrib><creatorcontrib>Boonla, Chanchai</creatorcontrib><creatorcontrib>Srisa-art, Monpicha</creatorcontrib><creatorcontrib>Ungjaroenwathana, Wattanachai</creatorcontrib><creatorcontrib>Tosukhowong, Piyaratana</creatorcontrib><title>Urinary stone risk factors in the descendants of patients with kidney stone disease</title><title>Pediatric nephrology (Berlin, West)</title><addtitle>Pediatr Nephrol</addtitle><addtitle>Pediatr Nephrol</addtitle><description>Background
Evidence has indicated that immediate family members of nephrolithiasis patients had high opportunity to develop stones. However, they are usually not regarded to be at risk, since it is unclear if there are any lithogenic abnormalities found in non-stone-forming nephrolithiasis relatives. Our aim was to investigate urinary metabolic abnormalities in the children of nephrolithiasis patients, compared with the general population.
Methods
The 24-h urinary metabolic profile was studied for 28 calcium oxalate nephrolithiasis patients (NL) and 46 of their descendants (ND), as well as 40 non-stone-forming volunteers (V) and 34 of their descendants (VD).
Results
There was no difference between age, gender, and serum creatinine between NL vs. V (parental groups) and ND vs. VD (descendant groups). High urinary oxalate in nephrolithiasis and urinary calcium in their descendants was detected. In addition, an elevated urinary excretion rate of calcium, phosphate, protein, and albumin, along with low citrate excretion and high urinary supersaturation was observed in both the nephrolithiasis patients and their descendants. Approximate 17.8–24.4% of the nephrolithiasis descendants had a urinary supersaturation higher than the nephrolithiasis level, but none was found in VD group. The level of urinary supersaturation index was correlated with urinary protein and albumin excretion in nephrolithiasis family.
Conclusion
It was demonstrated that nephrolithiasis offspring carried several urinary metabolic risks predisposing to stone formation which are similar to their parents, and about one in every five nephrolithiasis children had nephrolithiasis level urinary supersaturation.</description><subject>Albumin</subject><subject>Calcium (urinary)</subject><subject>Calcium oxalate</subject><subject>Calcium phosphates</subject><subject>Children</subject><subject>Citric acid</subject><subject>Creatinine</subject><subject>Excretion</subject><subject>Families & family life</subject><subject>Kidney stones</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Nephrolithiasis</subject><subject>Nephrology</subject><subject>Original Article</subject><subject>Oxalic acid</subject><subject>Pediatrics</subject><subject>Risk factors</subject><subject>Sexually transmitted diseases</subject><subject>STD</subject><subject>Urology</subject><issn>0931-041X</issn><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1LAzEQhoMoWqs_wIsEvHhZnWyS3c1RxC8QPGjBW0iTWY222ZpsEf-9WVsVBE8ZyPO-MzyEHDA4YQD1aQIQVV0AawquyrpgG2TEBC8LpprHTTICxVkBgj3ukN2UXgCgkU21TXZKJZWQIEfkfhJ9MPGDpr4LSKNPr7Q1tu9ioj7Q_hmpw2QxOBP6RLuWLkzvcZjfff9MX70L-J12PqFJuEe2WjNLuL9-x2RyefFwfl3c3l3dnJ_dFpbXZV80RklnW9ugZE5Nq8YK3gjFp9w5rAVj6EojBReitDWYlptKKmcFtNZNWWv4mByvehexe1ti6vXc51NnMxOwWyZdQvaQRUmW0aM_6Eu3jCFf90UxVUkYKLaibOxSitjqRfTzbEcz0INxvTKus3E9GNdD5nDdvJzO0f0kvhVnoFwBKX-FJ4y_q_9v_QQqLIwI</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Dissayabutra, Thasinas</creator><creator>Kalpongkul, Nuttiya</creator><creator>Rattanaphan, Jakkhaphan</creator><creator>Boonla, Chanchai</creator><creator>Srisa-art, Monpicha</creator><creator>Ungjaroenwathana, Wattanachai</creator><creator>Tosukhowong, Piyaratana</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7066-0870</orcidid></search><sort><creationdate>20180701</creationdate><title>Urinary stone risk factors in the descendants of patients with kidney stone disease</title><author>Dissayabutra, Thasinas ; Kalpongkul, Nuttiya ; Rattanaphan, Jakkhaphan ; Boonla, Chanchai ; Srisa-art, Monpicha ; Ungjaroenwathana, Wattanachai ; Tosukhowong, Piyaratana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-8a95dcfc8e51d9b68c438493b3dde7411ed2a543442c70af3a659dc40fcdb1fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Albumin</topic><topic>Calcium (urinary)</topic><topic>Calcium oxalate</topic><topic>Calcium phosphates</topic><topic>Children</topic><topic>Citric acid</topic><topic>Creatinine</topic><topic>Excretion</topic><topic>Families & family life</topic><topic>Kidney stones</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Nephrolithiasis</topic><topic>Nephrology</topic><topic>Original Article</topic><topic>Oxalic acid</topic><topic>Pediatrics</topic><topic>Risk factors</topic><topic>Sexually transmitted diseases</topic><topic>STD</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dissayabutra, Thasinas</creatorcontrib><creatorcontrib>Kalpongkul, Nuttiya</creatorcontrib><creatorcontrib>Rattanaphan, Jakkhaphan</creatorcontrib><creatorcontrib>Boonla, Chanchai</creatorcontrib><creatorcontrib>Srisa-art, Monpicha</creatorcontrib><creatorcontrib>Ungjaroenwathana, Wattanachai</creatorcontrib><creatorcontrib>Tosukhowong, Piyaratana</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric nephrology (Berlin, West)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dissayabutra, Thasinas</au><au>Kalpongkul, Nuttiya</au><au>Rattanaphan, Jakkhaphan</au><au>Boonla, Chanchai</au><au>Srisa-art, Monpicha</au><au>Ungjaroenwathana, Wattanachai</au><au>Tosukhowong, Piyaratana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary stone risk factors in the descendants of patients with kidney stone disease</atitle><jtitle>Pediatric nephrology (Berlin, West)</jtitle><stitle>Pediatr Nephrol</stitle><addtitle>Pediatr Nephrol</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>33</volume><issue>7</issue><spage>1173</spage><epage>1181</epage><pages>1173-1181</pages><issn>0931-041X</issn><eissn>1432-198X</eissn><abstract>Background
Evidence has indicated that immediate family members of nephrolithiasis patients had high opportunity to develop stones. However, they are usually not regarded to be at risk, since it is unclear if there are any lithogenic abnormalities found in non-stone-forming nephrolithiasis relatives. Our aim was to investigate urinary metabolic abnormalities in the children of nephrolithiasis patients, compared with the general population.
Methods
The 24-h urinary metabolic profile was studied for 28 calcium oxalate nephrolithiasis patients (NL) and 46 of their descendants (ND), as well as 40 non-stone-forming volunteers (V) and 34 of their descendants (VD).
Results
There was no difference between age, gender, and serum creatinine between NL vs. V (parental groups) and ND vs. VD (descendant groups). High urinary oxalate in nephrolithiasis and urinary calcium in their descendants was detected. In addition, an elevated urinary excretion rate of calcium, phosphate, protein, and albumin, along with low citrate excretion and high urinary supersaturation was observed in both the nephrolithiasis patients and their descendants. Approximate 17.8–24.4% of the nephrolithiasis descendants had a urinary supersaturation higher than the nephrolithiasis level, but none was found in VD group. The level of urinary supersaturation index was correlated with urinary protein and albumin excretion in nephrolithiasis family.
Conclusion
It was demonstrated that nephrolithiasis offspring carried several urinary metabolic risks predisposing to stone formation which are similar to their parents, and about one in every five nephrolithiasis children had nephrolithiasis level urinary supersaturation.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29594505</pmid><doi>10.1007/s00467-018-3927-1</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7066-0870</orcidid></addata></record> |
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| ispartof | Pediatric nephrology (Berlin, West), 2018-07, Vol.33 (7), p.1173-1181 |
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| language | eng |
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| subjects | Albumin Calcium (urinary) Calcium oxalate Calcium phosphates Children Citric acid Creatinine Excretion Families & family life Kidney stones Medicine Medicine & Public Health Metabolism Nephrolithiasis Nephrology Original Article Oxalic acid Pediatrics Risk factors Sexually transmitted diseases STD Urology |
| title | Urinary stone risk factors in the descendants of patients with kidney stone disease |
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