Absence of 1p/19q codeletion in oligodendroglioma-like areas of pilocytic astrocytomas
The presence of oligodendroglioma-like areas in pilocytic astrocytoma may give rise to pathologic diagnostic uncertainty. This study aims to determine if the oligodendroglioma-like areas present in some pilocytic astrocytomas (PA) possess the signature 1p/19q codeletion that is characteristic of cla...
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| Veröffentlicht in: | Clinical neuropathology 2018-07, Vol.37 (4), p.182-185 |
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| container_title | Clinical neuropathology |
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| creator | Frazer, Beth Kearney, Hugh Cryan, Jane Beausang, Alan Brett, Francesca Farrell, Michael A Buckley, Patrick G |
| description | The presence of oligodendroglioma-like areas in pilocytic astrocytoma may give rise to pathologic diagnostic uncertainty. This study aims to determine if the oligodendroglioma-like areas present in some pilocytic astrocytomas (PA) possess the signature 1p/19q codeletion that is characteristic of classical oligodendroglioma. Array comparative genomic hybridization was carried out on 12 PA samples, from which oligodendroglioma-like areas were microdissected and used as the template DNA source. 1p/19q codeletions were not found in any of the oligodendroglioma areas in PAs. We conclude that PAs with oligodendroglioma-like areas do not share the same molecular genetics as classic oligodendroglioma.
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| doi_str_mv | 10.5414/NP301062 |
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This study aims to determine if the oligodendroglioma-like areas present in some pilocytic astrocytomas (PA) possess the signature 1p/19q codeletion that is characteristic of classical oligodendroglioma. Array comparative genomic hybridization was carried out on 12 PA samples, from which oligodendroglioma-like areas were microdissected and used as the template DNA source. 1p/19q codeletions were not found in any of the oligodendroglioma areas in PAs. We conclude that PAs with oligodendroglioma-like areas do not share the same molecular genetics as classic oligodendroglioma.
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| subjects | Adolescent Astrocytoma - genetics Astrocytoma - pathology Brain cancer Brain Neoplasms - genetics Brain Neoplasms - pathology Child Child, Preschool Chromosome Deletion Chromosomes Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 19 - genetics Female Humans Hybridization In Situ Hybridization, Fluorescence - methods Kinases Mutation Neuropathology Oligodendroglioma - genetics Tumors |
| title | Absence of 1p/19q codeletion in oligodendroglioma-like areas of pilocytic astrocytomas |
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