Dysregulation of autophagy in rat liver with mitochondrial DNA depletion induced by the nucleoside analogue zidovudine

The nucleoside reverse transcriptase inhibitor zidovudine (AZT), used in HIV infection treatment, induces mitochondrial DNA (mtDNA) depletion. A cause–effect relationship between mtDNA status alterations and autophagy has been reported. Both events are common in several liver diseases, including hep...

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Veröffentlicht in:	Archives of toxicology 2018-06, Vol.92 (6), p.2109-2118
Hauptverfasser:	Santos-Llamas, Ana, Monte, Maria J., Marin, Jose J. G., Perez, Maria J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Accumulation AKT protein Animal tissues Animals Antioxidants Antiretroviral drugs Autophagosomes - drug effects Autophagosomes - pathology Autophagy Autophagy - drug effects Biomarkers Biomedical and Life Sciences Biomedicine Cell Line, Tumor Coding Cytochrome Cytochrome-c oxidase Degradation Deoxyribonucleic acid Depletion DNA DNA, Mitochondrial - drug effects Drinking water Drug therapy Environmental Health Gene expression Gene regulation Hepatocellular carcinoma Hepatocytes Kidneys Liver Liver - drug effects Liver - pathology Liver cancer Liver diseases Male Mitochondrial DNA Nucleoside analogs Nucleoside reverse transcriptase inhibitors Nucleosides Occupational Medicine/Industrial Medicine Organ Toxicity and Mechanisms Phagocytosis Pharmacology/Toxicology Proteins Rats Rats, Wistar Reverse Transcriptase Inhibitors - toxicity RNA-directed DNA polymerase Signaling TOR protein Toxicity Transcription factors Zidovudine Zidovudine - toxicity
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