Retinoic Acid Increases Fatty Acid Oxidation and Irisin Expression in Skeletal Muscle Cells and Impacts Irisin In Vivo

Background/Aims: All-trans retinoic acid (ATRA) has protective effects against obesity and metabolic syndrome. We here aimed to gain further insight into the interaction of ATRA with skeletal muscle metabolism and secretory activity as important players in metabolic health. Methods: Cultured murine...

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Veröffentlicht in:	Cellular Physiology and Biochemistry 2018-01, Vol.46 (1), p.187-202
Hauptverfasser:	Amengual, Jaume, García-Carrizo, Francisco J., Arreguín, Andrea, Mušinović, Hana, Granados, Nuria, Palou, Andreu, Bonet, M. Luisa, Ribot, Joan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes AMP-Activated Protein Kinases - metabolism AMPK Animals Antibiotics Biological oxidation (Metabolism) Cell Line Cytotoxicity Diabetes Energy Enzyme-Linked Immunosorbent Assay Fatty acid/oxidation Fatty acids Fatty Acids - metabolism Fibroblast Growth Factors - metabolism Fibronectins - blood Fibronectins - genetics Fibronectins - metabolism Glucose Glucose - metabolism Health aspects Homeostasis Insulin Interleukin-6 - metabolism Intramyocellular lipids Kinases Lipid Metabolism - drug effects Lipids Liver Liver - drug effects Liver - metabolism Liver - pathology Male Metabolism Mice Muscle Muscle, Skeletal - cytology Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscles Musculoskeletal system Myokines Neuropeptides - analysis Neuropeptides - metabolism Nuclear receptors Obesity Original Paper Oxidation Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism PPAR delta - agonists PPAR delta - metabolism PPAR-beta - agonists PPAR-beta - metabolism PPARβ/δ Proteins Retinoid X Receptors - agonists Retinoid X Receptors - metabolism Retinoids/vitamin A Rodents Testing Tretinoin Tretinoin - pharmacology Triglycerides - metabolism Vitamin A
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