Low concordance between surgical and radiological assessment of degree of resection and treatment-related hypothalamic damage: results of KRANIOPHARYNGEOM 2007
Background Assessment of presurgical hypothalamic involvement (psHI) and treatment-related hypothalamic damage (trHD) is relevant for the decision on risk-adapted treatment and rehabilitation strategies in craniopharyngioma. Patients and methods 129 surgical reports of childhood-onset craniopharyngi...
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| Veröffentlicht in: | Pituitary 2018-08, Vol.21 (4), p.371-378 |
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| creator | Müller, Hermann L. Reichel, Julia Boekhoff, Svenja Warmuth-Metz, Monika Eveslage, Maria Peng, Junxiang Flitsch, Jörg |
| description | Background
Assessment of presurgical hypothalamic involvement (psHI) and treatment-related hypothalamic damage (trHD) is relevant for the decision on risk-adapted treatment and rehabilitation strategies in craniopharyngioma.
Patients and methods
129 surgical reports of childhood-onset craniopharyngioma patients recruited 2007–2014 in KRANIOPHARYNGEOM 2007 were analyzed. Data on psHI were available based on surgeon’s (63%), reference neuroradiologist’s (95%), and local radiologist’s (23%) assessment. The surgical degree of resection (DoR) was assessed by neurosurgeon (95%), reference neuroradiologist (73%), and local radiologist (61%). TrHD was assessed by neurosurgeon (33%), by reference neuroradiologist (95%), and by local radiologist (2%). Neurosurgical center size was categorized based on patient load.
Results
Surgical assessments on psHI (n = 78), DoR (n = 89) and trHD (n = 42) as documented in surgical reports could be compared with the assessment of respective parameters by reference neuroradiologist. Differences with regard to DoR (p = 0.0001) and trHD (p |
| doi_str_mv | 10.1007/s11102-018-0883-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2019474654</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2019063757</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-1fb3b38bb52655a5a0e8030b286c8ff2b478846b166d0c14d81272873d4c87cd3</originalsourceid><addsrcrecordid>eNp1kd1qFDEYhoMotq5egCcS8MST0fxOsp4tpbbFtStFQY-GTPLNdspMsiYZSq-mt9pMd1UQPMpH8rxvEh6EXlPynhKiPiRKKWEVoboiWvNKPkHHVCpeKUH40zJzXVdc0B9H6EVKN4SUFBfP0RFbSr1kTB6j-3W4xTZ4G6Iz3gJuId8CeJymuO2tGbDxDkfj-jCEw0ZKkNIIPuPQYQfbCDBPERLY3Af_GMkRTJ6hKsJgMjh8fbcL-doMZuwtdmY0W_g4h6Yhpzn_-Wp1ebH5er66-nl5drr5gln540v0rDNDgleHdYG-fzr9dnJerTdnFyerdWW5YrmiXctbrttWslpKIw0BTThpma6t7jrWCqW1qFta145YKpymTDGtuBNWK-v4Ar3b9-5i-DVBys3YJwvDYDyEKTWM0KVQopaioG__QW_CFH153SNFaq6KgwWie8rGkFKErtnFfjTxrqGkme01e3tNsdfM9hpZMm8OzVM7gvuT-K2rAGwPpHLktxD_Xv3_1gfZYqUB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2019063757</pqid></control><display><type>article</type><title>Low concordance between surgical and radiological assessment of degree of resection and treatment-related hypothalamic damage: results of KRANIOPHARYNGEOM 2007</title><source>SpringerLink Journals - AutoHoldings</source><creator>Müller, Hermann L. ; Reichel, Julia ; Boekhoff, Svenja ; Warmuth-Metz, Monika ; Eveslage, Maria ; Peng, Junxiang ; Flitsch, Jörg</creator><creatorcontrib>Müller, Hermann L. ; Reichel, Julia ; Boekhoff, Svenja ; Warmuth-Metz, Monika ; Eveslage, Maria ; Peng, Junxiang ; Flitsch, Jörg</creatorcontrib><description>Background
Assessment of presurgical hypothalamic involvement (psHI) and treatment-related hypothalamic damage (trHD) is relevant for the decision on risk-adapted treatment and rehabilitation strategies in craniopharyngioma.
Patients and methods
129 surgical reports of childhood-onset craniopharyngioma patients recruited 2007–2014 in KRANIOPHARYNGEOM 2007 were analyzed. Data on psHI were available based on surgeon’s (63%), reference neuroradiologist’s (95%), and local radiologist’s (23%) assessment. The surgical degree of resection (DoR) was assessed by neurosurgeon (95%), reference neuroradiologist (73%), and local radiologist (61%). TrHD was assessed by neurosurgeon (33%), by reference neuroradiologist (95%), and by local radiologist (2%). Neurosurgical center size was categorized based on patient load.
Results
Surgical assessments on psHI (n = 78), DoR (n = 89) and trHD (n = 42) as documented in surgical reports could be compared with the assessment of respective parameters by reference neuroradiologist. Differences with regard to DoR (p = 0.0001) and trHD (p < 0.0001) were detectable between surgeon’s and reference neuroradiologist’s assessment, whereas psHI was assessed similarly. Concordance for DoR and trHD was observed in 48 and 62%, respectively. Surgeons estimated a higher rate of complete resections and a lower rate of trHD. Neuroradiological reference assessment of trHD had higher predictive value for hypothalamic sequelae then surgical assessment. Observed differences were not related to neurosurgical center size.
Conclusions
Observed differences between surgical and neuroradiological estimation of risk factors in craniopharyngioma support the necessity of neuroradiological reference review to assure standards of quality. This could be established by central internet-based neuroradiological review in KRANIOPHARYNGEOM 2007. Standardization of surgical reports including specific assessment of tumor/damage location is recommended.</description><identifier>ISSN: 1386-341X</identifier><identifier>EISSN: 1573-7403</identifier><identifier>DOI: 10.1007/s11102-018-0883-5</identifier><identifier>PMID: 29589225</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Children ; Complications ; Data processing ; Endocrinology ; Human Physiology ; Hypothalamus ; Medicine ; Medicine & Public Health ; Neoplasia ; Neurosurgery ; Patients ; Pituitary ; Rehabilitation ; Risk factors ; Standardization</subject><ispartof>Pituitary, 2018-08, Vol.21 (4), p.371-378</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Pituitary is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-1fb3b38bb52655a5a0e8030b286c8ff2b478846b166d0c14d81272873d4c87cd3</citedby><cites>FETCH-LOGICAL-c372t-1fb3b38bb52655a5a0e8030b286c8ff2b478846b166d0c14d81272873d4c87cd3</cites><orcidid>0000-0003-4929-9966</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11102-018-0883-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11102-018-0883-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29589225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Müller, Hermann L.</creatorcontrib><creatorcontrib>Reichel, Julia</creatorcontrib><creatorcontrib>Boekhoff, Svenja</creatorcontrib><creatorcontrib>Warmuth-Metz, Monika</creatorcontrib><creatorcontrib>Eveslage, Maria</creatorcontrib><creatorcontrib>Peng, Junxiang</creatorcontrib><creatorcontrib>Flitsch, Jörg</creatorcontrib><title>Low concordance between surgical and radiological assessment of degree of resection and treatment-related hypothalamic damage: results of KRANIOPHARYNGEOM 2007</title><title>Pituitary</title><addtitle>Pituitary</addtitle><addtitle>Pituitary</addtitle><description>Background
Assessment of presurgical hypothalamic involvement (psHI) and treatment-related hypothalamic damage (trHD) is relevant for the decision on risk-adapted treatment and rehabilitation strategies in craniopharyngioma.
Patients and methods
129 surgical reports of childhood-onset craniopharyngioma patients recruited 2007–2014 in KRANIOPHARYNGEOM 2007 were analyzed. Data on psHI were available based on surgeon’s (63%), reference neuroradiologist’s (95%), and local radiologist’s (23%) assessment. The surgical degree of resection (DoR) was assessed by neurosurgeon (95%), reference neuroradiologist (73%), and local radiologist (61%). TrHD was assessed by neurosurgeon (33%), by reference neuroradiologist (95%), and by local radiologist (2%). Neurosurgical center size was categorized based on patient load.
Results
Surgical assessments on psHI (n = 78), DoR (n = 89) and trHD (n = 42) as documented in surgical reports could be compared with the assessment of respective parameters by reference neuroradiologist. Differences with regard to DoR (p = 0.0001) and trHD (p < 0.0001) were detectable between surgeon’s and reference neuroradiologist’s assessment, whereas psHI was assessed similarly. Concordance for DoR and trHD was observed in 48 and 62%, respectively. Surgeons estimated a higher rate of complete resections and a lower rate of trHD. Neuroradiological reference assessment of trHD had higher predictive value for hypothalamic sequelae then surgical assessment. Observed differences were not related to neurosurgical center size.
Conclusions
Observed differences between surgical and neuroradiological estimation of risk factors in craniopharyngioma support the necessity of neuroradiological reference review to assure standards of quality. This could be established by central internet-based neuroradiological review in KRANIOPHARYNGEOM 2007. Standardization of surgical reports including specific assessment of tumor/damage location is recommended.</description><subject>Children</subject><subject>Complications</subject><subject>Data processing</subject><subject>Endocrinology</subject><subject>Human Physiology</subject><subject>Hypothalamus</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoplasia</subject><subject>Neurosurgery</subject><subject>Patients</subject><subject>Pituitary</subject><subject>Rehabilitation</subject><subject>Risk factors</subject><subject>Standardization</subject><issn>1386-341X</issn><issn>1573-7403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kd1qFDEYhoMotq5egCcS8MST0fxOsp4tpbbFtStFQY-GTPLNdspMsiYZSq-mt9pMd1UQPMpH8rxvEh6EXlPynhKiPiRKKWEVoboiWvNKPkHHVCpeKUH40zJzXVdc0B9H6EVKN4SUFBfP0RFbSr1kTB6j-3W4xTZ4G6Iz3gJuId8CeJymuO2tGbDxDkfj-jCEw0ZKkNIIPuPQYQfbCDBPERLY3Af_GMkRTJ6hKsJgMjh8fbcL-doMZuwtdmY0W_g4h6Yhpzn_-Wp1ebH5er66-nl5drr5gln540v0rDNDgleHdYG-fzr9dnJerTdnFyerdWW5YrmiXctbrttWslpKIw0BTThpma6t7jrWCqW1qFta145YKpymTDGtuBNWK-v4Ar3b9-5i-DVBys3YJwvDYDyEKTWM0KVQopaioG__QW_CFH153SNFaq6KgwWie8rGkFKErtnFfjTxrqGkme01e3tNsdfM9hpZMm8OzVM7gvuT-K2rAGwPpHLktxD_Xv3_1gfZYqUB</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Müller, Hermann L.</creator><creator>Reichel, Julia</creator><creator>Boekhoff, Svenja</creator><creator>Warmuth-Metz, Monika</creator><creator>Eveslage, Maria</creator><creator>Peng, Junxiang</creator><creator>Flitsch, Jörg</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4929-9966</orcidid></search><sort><creationdate>20180801</creationdate><title>Low concordance between surgical and radiological assessment of degree of resection and treatment-related hypothalamic damage: results of KRANIOPHARYNGEOM 2007</title><author>Müller, Hermann L. ; Reichel, Julia ; Boekhoff, Svenja ; Warmuth-Metz, Monika ; Eveslage, Maria ; Peng, Junxiang ; Flitsch, Jörg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-1fb3b38bb52655a5a0e8030b286c8ff2b478846b166d0c14d81272873d4c87cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Children</topic><topic>Complications</topic><topic>Data processing</topic><topic>Endocrinology</topic><topic>Human Physiology</topic><topic>Hypothalamus</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoplasia</topic><topic>Neurosurgery</topic><topic>Patients</topic><topic>Pituitary</topic><topic>Rehabilitation</topic><topic>Risk factors</topic><topic>Standardization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Müller, Hermann L.</creatorcontrib><creatorcontrib>Reichel, Julia</creatorcontrib><creatorcontrib>Boekhoff, Svenja</creatorcontrib><creatorcontrib>Warmuth-Metz, Monika</creatorcontrib><creatorcontrib>Eveslage, Maria</creatorcontrib><creatorcontrib>Peng, Junxiang</creatorcontrib><creatorcontrib>Flitsch, Jörg</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pituitary</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Müller, Hermann L.</au><au>Reichel, Julia</au><au>Boekhoff, Svenja</au><au>Warmuth-Metz, Monika</au><au>Eveslage, Maria</au><au>Peng, Junxiang</au><au>Flitsch, Jörg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low concordance between surgical and radiological assessment of degree of resection and treatment-related hypothalamic damage: results of KRANIOPHARYNGEOM 2007</atitle><jtitle>Pituitary</jtitle><stitle>Pituitary</stitle><addtitle>Pituitary</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>21</volume><issue>4</issue><spage>371</spage><epage>378</epage><pages>371-378</pages><issn>1386-341X</issn><eissn>1573-7403</eissn><abstract>Background
Assessment of presurgical hypothalamic involvement (psHI) and treatment-related hypothalamic damage (trHD) is relevant for the decision on risk-adapted treatment and rehabilitation strategies in craniopharyngioma.
Patients and methods
129 surgical reports of childhood-onset craniopharyngioma patients recruited 2007–2014 in KRANIOPHARYNGEOM 2007 were analyzed. Data on psHI were available based on surgeon’s (63%), reference neuroradiologist’s (95%), and local radiologist’s (23%) assessment. The surgical degree of resection (DoR) was assessed by neurosurgeon (95%), reference neuroradiologist (73%), and local radiologist (61%). TrHD was assessed by neurosurgeon (33%), by reference neuroradiologist (95%), and by local radiologist (2%). Neurosurgical center size was categorized based on patient load.
Results
Surgical assessments on psHI (n = 78), DoR (n = 89) and trHD (n = 42) as documented in surgical reports could be compared with the assessment of respective parameters by reference neuroradiologist. Differences with regard to DoR (p = 0.0001) and trHD (p < 0.0001) were detectable between surgeon’s and reference neuroradiologist’s assessment, whereas psHI was assessed similarly. Concordance for DoR and trHD was observed in 48 and 62%, respectively. Surgeons estimated a higher rate of complete resections and a lower rate of trHD. Neuroradiological reference assessment of trHD had higher predictive value for hypothalamic sequelae then surgical assessment. Observed differences were not related to neurosurgical center size.
Conclusions
Observed differences between surgical and neuroradiological estimation of risk factors in craniopharyngioma support the necessity of neuroradiological reference review to assure standards of quality. This could be established by central internet-based neuroradiological review in KRANIOPHARYNGEOM 2007. Standardization of surgical reports including specific assessment of tumor/damage location is recommended.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29589225</pmid><doi>10.1007/s11102-018-0883-5</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4929-9966</orcidid></addata></record> |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Children Complications Data processing Endocrinology Human Physiology Hypothalamus Medicine Medicine & Public Health Neoplasia Neurosurgery Patients Pituitary Rehabilitation Risk factors Standardization |
| title | Low concordance between surgical and radiological assessment of degree of resection and treatment-related hypothalamic damage: results of KRANIOPHARYNGEOM 2007 |
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