Synthesis of (aminoalkyl)cycleanine analogues: cytotoxicity, cellular uptake, and apoptosis induction in ovarian cancer cells

[Display omitted] Our previous studies demonstrated that cycleanine, a macrocyclic bisbenzylisoquinoline (BBIQ) alkaloid, showed potent anti-ovarian cancer activity via apoptosis induction. Here, we synthesized two novel (aminoalkyl)cycleanine analogues (2 and 3) through a simple and efficient two-s...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2018-05, Vol.28 (9), p.1652-1656
Hauptverfasser:	Uche, Fidelia Ijeoma, McCullagh, James, Claridge, Timothy W.D., Richardson, Alan, Li, Wen-Wu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemical synthesis Alkaloids - chemistry Alkaloids - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Bisbenzylisoquinoline alkaloid Cell Cycle - drug effects Cell Line Cell Proliferation - drug effects Cellular uptake Cycleanine Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans Isoquinolines - chemical synthesis Isoquinolines - chemistry Isoquinolines - pharmacology Menispermaceae - chemistry Molecular Structure Ovarian cancer Semi-synthesis Structure-Activity Relationship
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